A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins

Autor: Dinesh C. Soares, Shaun Mackie, Sheila Christie, Elizabeth A. Blackburn, Gareth James Briggs, David J. Porteous, Jennifer E. Eykelenboom, Walter J. Muir, Nicholas J. Bradshaw, Elise L.V. Malavasi, M. P. Malloy, J. Kirsty Millar, Fumiaki Ogawa, Janice Bramham, Martin A. Wear, Paraskevi Makedonopoulou, Andrew M. McIntosh, Douglas Blackwood

Publikováno v: Human Molecular Genetics
Eykelenboom, J E, Briggs, G J, Bradshaw, N J, Soares, D C, Ogawa, F, Christie, S, Malavasi, E L V, Makedonopoulou, P, Mackie, S, Malloy, M P, Wear, M A, Blackburn, E A, Bramham, J, Mcintosh, A M, Blackwood, D H, Muir, W J, Porteous, D J & Millar, J K 2012, ' A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins ', Human Molecular Genetics, vol. 21, no. 15, pp. 3374-3386 . https://doi.org/10.1093/hmg/dds169

Disrupted-In-Schizophrenia 1 (DISC1) was identified as a risk factor for psychiatric illness through its disruption by a balanced chromosomal translocation, t(1;11)(q42.1;q14.3), that co-segregates with schizophrenia, bipolar disorder and depression.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf608bb1c71feccfc1a425af7044675
https://doi.org/10.1093/hmg/dds169

A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity

Autor: Susanne Pettersson, Janice Bramham, Bartosz Wawrzynow, Alicja Zylicz, Kathryn L. Ball, Erin G. Worrall, Ted R. Hupp

Publikováno v: Wawrzynow, B, Pettersson, S, Zylicz, A, Bramham, J, Worrall, E, Hupp, T R & Ball, K L 2009, ' A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity ', Journal of Biological Chemistry, vol. 284, no. 17, pp. 11517-11530 . https://doi.org/10.1074/jbc.M809294200

The MDM2 oncoprotein plays multiple regulatory roles in the control of p53-dependent gene expression. A picture of MDM2 is emerging where structurally discrete but interdependent functional domains are linked through changes in conformation. The doma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1936e5af2fdd5fd43543de975d417843
https://doi.org/10.1074/jbc.m809294200

Functional Insights from the Structure of the Multifunctional C345C Domain of C5 of Complement

Autor: Dinesh C. Soares, Ronald T. Ogata, Paul N. Barlow, Dušan Uhrín, Janice Bramham, Chuong-Thu Thai

Publikováno v: Journal of Biological Chemistry. 280:10636-10645

The complement protein C5 initiates assembly of the membrane attack complex. This remarkable process results in lysis of target cells and is fundamental to mammalian defense against infection. The 150-amino acid residue domain at the C terminus of C5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e1ffabe053c1e746195e70fac2b051
https://doi.org/10.1074/jbc.m413126200

Study of the molecular effects of disease-causing mutations in RANK using human protein expression models

Autor: Susan Clark, Julie C. Crockett, Angela Duthie, Subhajit Das, Janice Bramham

Publikováno v: Bone Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d13482d3f8b0124df51b7823d23755cf
https://doi.org/10.1530/boneabs.3.pp158

The uptake of Li+ into human 1321 N1 astrocytomas using 7Li NMR spectroscopy

Autor: Carter An, Frank G. Riddell, Janice Bramham

Publikováno v: Journal of Inorganic Biochemistry. 61:273-284

The uptake of Li+ ions into human 1321 N1 astrocytomas cultured on the surface of microcarrier beads was followed by 7Li NMR spectroscopy. The intracellular and extracellular 7Li resonances were separated by the use of dysprosium tripolyphosphate as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7625461fc661ee04e482726d51936db
https://doi.org/10.1016/0162-0134(95)00075-5