Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Janice A. Vasko"'
Autor:
Vernal R. Vaden, Janice A. Vasko, Lago Amparo M, John Fox, Sanjay Kumar, William F. Huffman, Maggie Schultz, Hyking Haley, James F. Callahan, Xiaoguang Liang, Bingming Yi, Theodore M. Danoff, Lorraine A. Fitzpatrick, M. Gowen, George B. Stroup, Nemeth Edward F, Christopher Matheny, Sandra J. Hoffman, Eric G. Delmar, Robert W. Marquis, Pradip K. Bhatnagar
Publikováno v:
Bone. 46:534-542
Daily subcutaneous administration of exogenous parathyroid hormone (PTH) promotes bone formation in patients with osteoporosis. Here we describe two novel, short-acting calcium-sensing receptor antagonists (SB-423562 and its orally bioavailable precu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fef11ce24fdec9f4461d59b0567f9f7
https://doi.org/10.1016/j.bone.2009.09.028
https://doi.org/10.1016/j.bone.2009.09.028
Autor:
Dennis S. Yamashita, Thaddeus A. Tomaszek, H.-J. Oh, M.W. Lark, S M Hwang, David J. Rickard, Ian E. James, Jae U. Jeong, Robert W. Marquis, George B. Stroup, M. Gowen, Shaji Kumar, Lauren Dare, Simon M. Blake, Daniel F. Veber, Janice A. Vasko-Moser
Publikováno v:
Bone. 40:122-131
Cathepsin K is an osteoclast-derived cysteine protease that has been implicated as playing a major role in bone resorption. A substantial body of evidence indicates that cathepsin K is critical in osteoclast-mediated bone resorption and suggests that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e6d676f9661e2618786dd5a638714d
https://doi.org/10.1016/j.bone.2006.07.015
https://doi.org/10.1016/j.bone.2006.07.015
Autor:
Janice A. Vasko-Moser, Sandra J. Hoffman, Michael W. Lark, William H. Miller, George B. Stroup, Maxine Gowen
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 302:205-211
An excess of thyroid hormone results in increased bone turnover and loss of bone mass in humans. Exogenous administration of thyroid hormone to rats has served as a model of human hyperthyroidism in which antiresorptive therapies have been tested. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003cece0f8aeaf8bdf440046dc7c1cf8
https://doi.org/10.1124/jpet.302.1.205
https://doi.org/10.1124/jpet.302.1.205
Autor:
Robert W. Marquis, Karl F. Erhard, Sandra J. Hoffman, Daniel F. Veber, Maxine Gowen, Ru Yu, Lauren Dare, Brian R. Smith, Michael W. Lark, Thadeus Tomaszek, Janice A. Vasko-Moser, Amit Bhattacharyya, Ian E. James, Simon M. Blake, George B. Stroup
Publikováno v:
Journal of Bone and Mineral Research. 16:1739-1746
Cathepsin K is a cysteine protease that plays an essential role in osteoclast-mediated degradation of the organic matrix of bone. Knockout of the enzyme in mice, as well as lack of functional enzyme in the human condition pycnodysostosis, results in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1ddae3d2bf5ed626eb85a813a302b4d
https://doi.org/10.1359/jbmr.2001.16.10.1739
https://doi.org/10.1359/jbmr.2001.16.10.1739
Autor:
Lauren Dare, George B. Stroup, M. Gowen, E.L Jenkins, Beata Lechowska, Janice A. Vasko-Moser, S.J. Hoffman
Publikováno v:
Bone. 28:532-537
In this study we determine the early time course of estrogen deficiency-induced bone loss in the cynomolgus monkey and examine the potential of this method for evaluating antiresorptive therapies. In two groups of animals, estrogen deficiency was ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461926f01a45192e06b21316163f8086
https://doi.org/10.1016/s8756-3282(01)00421-5
https://doi.org/10.1016/s8756-3282(01)00421-5
Autor:
David J. Rieman, William F. Huffaman, Kevin L. Salyers, Richard M. Keenan, Michael W. Lark, Janice A. Vasko-Moser, Thomas W. Ku, Maxine Gowen, Leonard M. Azzarano, Karl F. Erhard, Stephen T. Ross, Denise Zembryki, Bradbeer Jeremy N, Bondinell William E, Shing-Mei Hwang, William H. Miller, Kenneth A. Newlander, George B. Stroup, Beata Lechowska, Fred H. Drake, Keith W. Ward, Kyung O. Johanson, Brian R. Smith, Paula C. Adams, Ian E. James, R. Curtis Haltiwanger, Russell D. Cousins, Dalia R. Jakas, Sandra J. Hoffman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1807-1812
A new series of potent nonpeptide vitronectin receptor antagonists, based on a novel carbocyclic Gly-Asp mimetic, has been discovered. A representative of this series, SB 265123 (4), has 100% oral bioavailability in rats, and is orally active in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49bebe15e69e0b6c6398f79a6e04504c
https://doi.org/10.1016/s0960-894x(99)00283-8
https://doi.org/10.1016/s0960-894x(99)00283-8
Autor:
Angela S. Wong, James F. Callahan, William H. Miller, Catherine C.K. Yuan, Raul R. Calvo, Janice A. Vasko-Moser, Thomas W. Ku, Richard E. Valocik, Dennis T. Takata, Richard M. Keenan, Drake S. Eggleston, Michael F. Parker, Southall Linda Sue, S M Hwang, Paul F. Koster, William F. Huffman, Tobias Oregon Yellin, Chet Kwon, Irene N. Uzinskas, Bondinell William E, Fadia E. Ali, Dalia R. Jakas, Andrew J. Nichols, James Samanen, R. Curtis Haltiwanger, Kenneth A. Newlander
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2481-2486
In an investigation of the contribution of N-1 to the binding, antiaggregatory, and oral activity in 3-oxo-1,4-benzodiazepine-2-acetic acid based GPIIb/IIIa antagonists, a series of 2-benzazepine analogs, wherein N-1 of the 1,4-benzodiazepine nucleus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ef79983c86eb17cdad500249ba3114f
https://doi.org/10.1016/0960-894x(96)00432-5
https://doi.org/10.1016/0960-894x(96)00432-5
Autor:
George B. Stroup, Janice A. Vasko-Moser, G. Vaden, Shaji Kumar, Lauren Dare, C.A. Capriotti, S.J. Hoffman
Publikováno v:
Osteoarthritis and Cartilage. 14:S60-S61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8052241aa96efbb31f75bff66652ef6c
Design of a potent and orally active nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist
Autor:
Drake S. Eggleston, Angela S. Wong, Andrew J. Nichols, Chuan-Kui Yuan, R. Curtis Haltiwanger, William E. Bondinell, Paul F. Koster, William H. Miller, Joseph W. Venslavsky, William F. Huffman, Karl F. Erhard, S M Hwang, Janice A. Vasko-Moser, Thomas W. Ku, Chao Pin Lee, Stephen T. Ross, Dalia R. Jakas, Richard M. Keenan, J. Samanen, Richard E. Valocik, Charles W. De Brosse, Fadia E. Ali, Andrew Allen
Publikováno v:
Bioorganicmedicinal chemistry. 2(9)
The direct design of the potent nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist, 8-[[[4- (aminoiminomethyl)phenyl]amino]carbonyl]-2,3,4,5-tetrahydro-3-oxo- 4- (2-phenylethyl)-1H-1,4-benzodiazepine-2-acetic acid, (3) (SB 207448), based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247132c8d3e49be06ba5bb125e0be644
https://pubmed.ncbi.nlm.nih.gov/7712125
https://pubmed.ncbi.nlm.nih.gov/7712125
Autor:
A. Nichols, J. Samanen, Linda J. Kopaciewicz, Barbara L. Storer, Raul R. Calvo, Janice A. Vasko, Fadia E. Ali, Richard E. Valocik, Todd Romoff
Publikováno v:
Thrombosis research. 75(2)
The properties of SK&F 106760 [N alpha-acetyl-cyclo(S,S)-cysteinyl-N alpha-methyl-arginyl-glycyl-aspartyl-penicillamine-amide] as a GPIIb/IIIa antagonist have been studied in vitro and compared with those of the parent molecule, Ac-RGDS-NH2. Ac-RGDS-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f038539f7459aedb0882010c1353c3dd
https://pubmed.ncbi.nlm.nih.gov/7974388
https://pubmed.ncbi.nlm.nih.gov/7974388