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pro vyhledávání: '"Janice, M McCarthy"'
1AbstractDiscovery research for therapeutic antibodies and vaccine development requires an in-depth understanding of antibody-antigen interactions. Label-free techniques such as Surface Plasmon Resonance (SPR) enable the characterization of biomolecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70436e874ebff0746acde343f0d5f042
https://doi.org/10.1101/2022.12.05.519088
https://doi.org/10.1101/2022.12.05.519088
Autor:
Mengqi Zhang, Matthew B. Harms, David Goldstein, Janice M. McCarthy, Cristiane de Araújo Martins Moreno, Sahar Gelfman, Andrew S. Allen
Publikováno v:
Briefings in bioinformatics. 23(1)
Gene set-based signal detection analyses are used to detect an association between a trait and a set of genes by accumulating signals across the genes in the gene set. Since signal detection is concerned with identifying whether any of the genes in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049037a48c12109aebf132dfd0112cbd
https://pubmed.ncbi.nlm.nih.gov/34849577
https://pubmed.ncbi.nlm.nih.gov/34849577
Autor:
Edwin S. Iversen, Janice M. McCarthy, Holly K. Dressman, Joel R. Ross, Nelson J. Chao, Kirsten Bell Burdett, Gary Phillips, Gary Bruce Lipton
Publikováno v:
International Journal of Radiation Biology. 96:47-56
Purpose: Design and characterization of a radiation biodosimetry device are complicated by the fact that the requisite data are not available in the intended use population, namely humans e...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2826e4416f8ad4fee48139a6110966ed
https://doi.org/10.1080/09553002.2018.1532614
https://doi.org/10.1080/09553002.2018.1532614
Autor:
Janice M. McCarthy, Tracy Truong, Jiaxing Lin, Yu Jiang, Deanna L. Kroetz, Kouros Owzar, Alexander B. Sibley, Andrew S. Allen, Zhiguo Li, Katherina C. Chua
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-11 (2019)
BMC bioinformatics, vol 20, iss 1
BMC Bioinformatics
BMC bioinformatics, vol 20, iss 1
BMC Bioinformatics
Background Time- and dose-to-event phenotypes used in basic science and translational studies are commonly measured imprecisely or incompletely due to limitations of the experimental design or data collection schema. For example, drug-induced toxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fed4b23f509e494d246c9e5e2ea9b2
https://doi.org/10.1186/s12859-019-2899-x
https://doi.org/10.1186/s12859-019-2899-x
Signal detection analyses are used to assess whether there is any evidence of signal within a large collection of hypotheses. For example, we may wish to assess whether there is any evidence of association with disease among a set of biologically rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00923116a0c8e62c44c61e0baa38e54f
https://doi.org/10.1101/525840
https://doi.org/10.1101/525840
Autor:
Josée Dupuis, James B. Meigs, Xihong Lin, Andrew S. Allen, Chuanhua Xing, L. Adrienne Cupples, Janice M. McCarthy
Publikováno v:
Statistics in Medicine. 35:4226-4237
The case-control study is a common design for assessing the association between genetic exposures and a disease phenotype. Though association with a given (case-control) phenotype is always of primary interest, there is often considerable interest in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb0ffe8de8bd52d5d2a95aca3d7df4e1
https://doi.org/10.1002/sim.6976
https://doi.org/10.1002/sim.6976
Publikováno v:
BMC Bioinformatics
Background In order to better understand complex diseases, it is important to understand how genetic variation in the regulatory regions affects gene expression. Genetic variants found in these regulatory regions have been shown to activate transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8280d776db71797e665e41922823d81
https://pubmed.ncbi.nlm.nih.gov/27341818
https://pubmed.ncbi.nlm.nih.gov/27341818
Autor:
Chuanhua, Xing, Janice, M McCarthy, Josée, Dupuis, L, Adrienne Cupples, James, B Meigs, Xihong, Lin, Andrew, S Allen
Publikováno v:
Statistics in medicine. 35(23)
The case-control study is a common design for assessing the association between genetic exposures and a disease phenotype. Though association with a given (case-control) phenotype is always of primary interest, there is often considerable interest in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b79e6294a7c80c955edb0aa8f74c6f64
https://pubmed.ncbi.nlm.nih.gov/27241694
https://pubmed.ncbi.nlm.nih.gov/27241694
Publikováno v:
Genetic epidemiology. 39(3)
Compound heterozygous mutations are mutations that occur on different copies of genes and may completely “knock-out” gene function. Compound heterozygous mutations have been implicated in a large number of diseases, but there are few statistical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c21e80ba58952f263baff131f10b76
https://pubmed.ncbi.nlm.nih.gov/25631493
https://pubmed.ncbi.nlm.nih.gov/25631493