Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jani R, Bolla"'
Autor:
Abraham O. Oluwole, Robin A. Corey, Chelsea M. Brown, Victor M. Hernández-Rocamora, Phillip J. Stansfeld, Waldemar Vollmer, Jani R. Bolla, Carol V. Robinson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Bacterial cell wall enzymes and their precursors are critical targets for antibiotic development. Here, the authors investigate several biosynthetic enzymes with their substrates and show that the passage of substrates and products in the pathway is
Externí odkaz:
https://doaj.org/article/a1a15d916c894fcdb85734251559a178
Autor:
Ruitao Jin, Sitong He, Katrina A. Black, Oliver B. Clarke, Di Wu, Jani R. Bolla, Paul Johnson, Agalya Periasamy, Ahmad Wardak, Peter Czabotar, Peter M. Colman, Carol V. Robinson, Derek Laver, Brian J. Smith, Jacqueline M. Gulbis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The Kir potassium channels are known to operate and gate without a major conformational change. Here, the authors identify the permeation gate of Kir channels as a steric plug within the conduction pathway, describing how tightly associated anionic l
Externí odkaz:
https://doaj.org/article/400ab475f64247199cf3b4d67129ff32
Autor:
Josh P. Prince, Jani R. Bolla, Gemma L. M. Fisher, Jarno Mäkelä, Marjorie Fournier, Carol V. Robinson, Lidia K. Arciszewska, David J. Sherratt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
E. coli MukBEF is an SMC complex that plays key roles in chromosome organization-segregation. Here the authors show that the interaction between MukBEF and the Acyl Carrier Protein (AcpP) is essential for MukBEF activity in vitro (ATPase) and in vivo
Externí odkaz:
https://doaj.org/article/9764fc49f5434bec8e6cd75aea1813bf
Autor:
Yun Yang, Jiwei Liu, Bradley R. Clarke, Laura Seidel, Jani R. Bolla, Philip N. Ward, Peijun Zhang, Carol V. Robinson, Chris Whitfield, James H. Naismith
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The Wzc–Wza complex forms part of the bacterial extracellular polysaccharides synthesis machinery, where cycling of the Wzc between phosphorylation states is crucial to both synthesis and export. Here the authors report the structure of the Wzc oct
Externí odkaz:
https://doaj.org/article/953375ccf8f24a0f97419d2d1888d0c0
Publikováno v:
JACS Au, Vol 1, Iss 8, Pp 1147-1157 (2021)
Externí odkaz:
https://doaj.org/article/9f88b0faaddc45c5933366c814b4f715
Autor:
Katrina A. Black, Sitong He, Ruitao Jin, David M. Miller, Jani R. Bolla, Oliver B. Clarke, Paul Johnson, Monique Windley, Christopher J. Burns, Adam P. Hill, Derek Laver, Carol V. Robinson, Brian J. Smith, Jacqueline M. Gulbis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The transition between conducting and non-conducting states of K+ channels has been explained by conformational changes at the intracellular entrance to the conduction pathway. Here authors demonstrate that control over K+ currents in Kir channels is
Externí odkaz:
https://doaj.org/article/1df537b978c34d8f93ba5ec69176a90f
Autor:
Gemma LM Fisher, Jani R Bolla, Karthik V Rajasekar, Jarno Mäkelä, Rachel Baker, Man Zhou, Josh P Prince, Mathew Stracy, Carol V Robinson, Lidia K Arciszewska, David J Sherratt
Publikováno v:
eLife, Vol 10 (2021)
Structural Maintenance of Chromosomes (SMC) complexes have ubiquitous roles in compacting DNA linearly, thereby promoting chromosome organization-segregation. Interaction between the Escherichia coli SMC complex, MukBEF, and matS-bound MatP in the ch
Externí odkaz:
https://doaj.org/article/e79ddc8ecbd14d45bbe14bac256ab85d
Autor:
Tarick J. El-Baba, Corinne A. Lutomski, Sean A. Burnap, Jani R. Bolla, Lindsay A. Baker, Andrew J. Baldwin, Weston B. Struwe, Carol V. Robinson
Publikováno v:
Journal of the American Chemical Society. 145:8021-8032
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2e582e03e3a2fad46a74438c5e9f4ef
https://doi.org/10.1021/jacs.3c00291
https://doi.org/10.1021/jacs.3c00291
Publikováno v:
Essays in Biochemistry. 67:201-213
Integral membrane proteins are involved in a plethora of biological processes including cellular signalling, molecular transport, and catalysis. Many of these functions are mediated by non-covalent interactions with other proteins, substrates, metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c87b980129f870a4e5df6e87ffb8eb34
https://doi.org/10.1042/ebc20220169
https://doi.org/10.1042/ebc20220169
Autor:
Alessandra Ottonello, Jessica A. Wyllie, Oussama Yahiaoui, Shoujun Sun, Rebecca A. Koelln, Joshua A. Homer, Robert M. Johnson, Ewan Murray, Paul Williams, Jani R. Bolla, Carol V. Robinson, Thomas Fallon, Tatiana P. Soares da Costa, John E. Moses
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The alarming rise in superbugs that are resistant to drugs of last resort, including vancomycin-resistant enterococci and staphylococci, has become a significant global health hazard. Here, we report the click chemistry synthesis of an unprecedented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::716470a385bccb34c9ee3b2b964f0384
https://doi.org/10.1073/pnas.2208737120
https://doi.org/10.1073/pnas.2208737120