Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Jangsuk Oh"'
Autor:
Roland C. Schelker, Jessica Fioravanti, Fabio Mastrogiovanni, Jeremy G. Baldwin, Nisha Rana, Peng Li, Ping Chen, Timea Vadász, Rosanne Spolski, Christoph Heuser-Loy, Dragana Slavkovic-Lukic, Pedro Noronha, Giuseppe Damiano, Laura Raccosta, Daniela Maggioni, Sree Pullugula, Jian-Xin Lin, Jangsuk Oh, Patrick Grandinetti, Mario Lecce, Leo Hesse, Emilia Kocks, Azucena Martín-Santos, Claudia Gebhard, William G. Telford, Yun Ji, Nicholas P. Restifo, Vincenzo Russo, Michael Rehli, Wolfgang Herr, Warren J. Leonard, Luca Gattinoni
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract High frequencies of stem-like memory T cells in infusion products correlate with superior patient outcomes across multiple T cell therapy trials. Herein, we analyzed a published CRISPR activation screening to identify transcriptional regulat
Externí odkaz:
https://doaj.org/article/feb411feca9c417783b76fb6c8d7a885
Autor:
Rama K. Gurram, Danping Wei, Qiao Yu, Matthew J. Butcher, Xi Chen, Kairong Cui, Gangqing Hu, Mingzhu Zheng, Xiaoliang Zhu, Jangsuk Oh, Bing Sun, Joseph F. Urban, Jr., Keji Zhao, Warren J. Leonard, Jinfang Zhu
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112073- (2023)
Summary: Type 2 T helper (Th2) cells and group 2 innate lymphoid cells (ILC2s) provide protection against helminth infection and are involved in allergic responses. However, their relative importance and crosstalk during type 2 immune responses are s
Externí odkaz:
https://doaj.org/article/ce97580fbbb1471a8ada47a0cdde3d23
Autor:
Min Ren, Majid Kazemian, Ming Zheng, JianPing He, Peng Li, Jangsuk Oh, Wei Liao, Jessica Li, Jonathan Rajaseelan, Brian L. Kelsall, Gary Peltz, Warren J. Leonard
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Heterogeneous helper T (Th) cell responses contribute to differential susceptibility to immunological disorders. Here the authors perform haplotype-based computational screens of 16 inbred mouse strains to identify a transcription factor, p73, as an
Externí odkaz:
https://doaj.org/article/ffad1db4d4b34ec79a555bbe08c7c711
Autor:
Risa Ebina-Shibuya, Erin E West, Rosanne Spolski, Peng Li, Jangsuk Oh, Majid Kazemian, Daniel Gromer, Phillip Swanson, Ning Du, Dorian B McGavern, Warren J Leonard
Publikováno v:
eLife, Vol 10 (2021)
Thymic stromal lymphopoietin (TSLP) is a cytokine that acts directly on CD4+ T cells and dendritic cells to promote progression of asthma, atopic dermatitis, and allergic inflammation. However, a direct role for TSLP in CD8+ T-cell primary responses
Externí odkaz:
https://doaj.org/article/70d414cb9afa41f496ea4e0b5a5f4f9e
Autor:
Rosanne Spolski, Erin E West, Peng Li, Sharon Veenbergen, Sunny Yung, Majid Kazemian, Jangsuk Oh, Zu-Xi Yu, Alexandra F Freeman, Stephen M Holland, Philip M Murphy, Warren J Leonard
Publikováno v:
eLife, Vol 8 (2019)
Methicillin-resistant Staphylococcus aureus (MRSA) is a major hospital- and community-acquired pathogen, but the mechanisms underlying host-defense to MRSA remain poorly understood. Here, we investigated the role of IL-21 in this process. When admini
Externí odkaz:
https://doaj.org/article/b8ba3d2aac1c460f91739d99b4d97801
Autor:
Rosanne Spolski, Peng Li, Vivek Chandra, Boyoung Shin, Chengyu Liu, Jangsuk Oh, Min Ren, Yutaka Enomoto, Erin E. West, Stephen Christensen, Edwin C.K. Wan, Meili Ge, Jian-Xin Lin, Pandurangan Vijayanand, Ellen V. Rothenberg, Warren J. Leonard
SummaryThe IL-2 receptor α-chain (IL-2Rα/CD25) is constitutively expressed on DN2/DN3 thymocytes and Treg cells but induced by IL-2 on mature T and NK cells.Il2raexpression is regulated by a super-enhancer extensively bound by STAT5 in mature T cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0df3db8a263f22e90db3b0b2dbbff29b
https://doi.org/10.1101/2022.11.18.516445
https://doi.org/10.1101/2022.11.18.516445
Autor:
Christopher K. E. Bleck, Peng Li, Rosanne Spolski, Leonard M. Neckers, Jian Xin Lin, Luca Gattinoni, Juan Carlos García-Cañaveras, Daniel Gromer, Ning Du, Stephen M. Christensen, Warren J. Leonard, Jessica Fioravanti, Suman Mitra, Joshua D. Rabinowitz, Rosa Nguyen, Jangsuk Oh, Sanjivan Gautam, Dalton Hermans, Risa Ebina-Shibuya, Sharon Veenbergen
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 117, 6047-6055. National Academy of Sciences
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Proceedings of the National Academy of Sciences of the United States of America, 117, 6047-6055. National Academy of Sciences
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Interleukin (IL)-2 and IL-21 dichotomously shape CD8 + T cell differentiation. IL-2 drives terminal differentiation, generating cells that are poorly effective against tumors, whereas IL-21 promotes stem cell memory T cells (T SCM ) and antitumor res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bffe31d96b13ac0493e570267d480d74
https://doi.org/10.1073/pnas.1920413117
https://doi.org/10.1073/pnas.1920413117
Autor:
Peng Li, Risa Ebina-Shibuya, Erin E. West, Jangsuk Oh, Ning Du, Phillip A. Swanson, Majid Kazemian, Warren J. Leonard, Daniel Gromer, Rosanne Spolski, Dorian B. McGavern
Publikováno v:
eLife, Vol 10 (2021)
Thymic stromal lymphopoietin (TSLP) is a cytokine that acts directly on CD4+ T cells and dendritic cells to promote progression of asthma, atopic dermatitis, and allergic inflammation. However, a direct role for TSLP in CD8+ T-cell primary responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40273b8a78a3fab12c2148b2be63de06
https://elifesciences.org/articles/61912
https://elifesciences.org/articles/61912
Autor:
Peng Li, Majid Kazemian, Dorian B. McGavern, Ning Du, Warren J. Leonard, Daniel Gromer, Risa Ebina-Shibuya, Erin E. West, Rosanne Spolski, Phillip A. Swanson, Jangsuk Oh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c2791a3115122aa2b8f4c5995498ebd
https://doi.org/10.7554/elife.61912.sa2
https://doi.org/10.7554/elife.61912.sa2
Autor:
Dalton, Hermans, Sanjivan, Gautam, Juan C, García-Cañaveras, Daniel, Gromer, Suman, Mitra, Rosanne, Spolski, Peng, Li, Stephen, Christensen, Rosa, Nguyen, Jian-Xin, Lin, Jangsuk, Oh, Ning, Du, Sharon, Veenbergen, Jessica, Fioravanti, Risa, Ebina-Shibuya, Christopher, Bleck, Leonard M, Neckers, Joshua D, Rabinowitz, Luca, Gattinoni, Warren J, Leonard
Publikováno v:
Proc Natl Acad Sci U S A
Interleukin (IL)-2 and IL-21 dichotomously shape CD8(+) T cell differentiation. IL-2 drives terminal differentiation, generating cells that are poorly effective against tumors, whereas IL-21 promotes stem cell memory T cells (T(SCM)) and antitumor re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::06f771a4b28a0f2dda5761c8ae84df63
https://pubmed.ncbi.nlm.nih.gov/32123114
https://pubmed.ncbi.nlm.nih.gov/32123114