Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jang H. Han"'
Autor:
Stephen R. Coates, Qui-Lim Choo, Hyun Chul Song, Takashi Harada, Piero Pileri, Konrad Stadler, Michael Houghton, John M. Polo, Byoung J. Yoo, Catherine Greer, Mi Young Seo, Jang H. Han, Sergio Abrignani, Yasushi Uematsu, Markus Eickmann, Rino Rappuoli
Publikováno v:
Journal of Virology
We have expressed and characterized the severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein in cDNA-transfected mammalian cells. The full-length spike protein (S) was newly synthesized as an endoglycosidase H (endo H)-sensitive gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a0e9acabcafa016ff415e61a008c67
Autor:
Jeonghoon Sun, Tae Woo Kwon, Demetri Theodore Moustakas, Jang H. Han, Mi Young Seo, Hui-hua Lu, Jong Won Kim, Anang A. Shelat, Chon Saeng Kim
Publikováno v:
Journal of Virology. 77:571-582
Hepatitis C virus (HCV) is a positive-strand RNA virus that encodes a helicase required for viral replication. Although HCV does not replicate through a DNA intermediate, HCV helicase unwinds both RNA and DNA duplexes. An X-ray crystal structure of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021ca45c381056ab46b8d7af6268a33f
https://doi.org/10.1128/jvi.77.1.571-582.2003
https://doi.org/10.1128/jvi.77.1.571-582.2003
Publikováno v:
Journal of Virology. 73:2909-2915
Hepatitis G virus (HGV) nonstructural protein 3 (NS3) contains amino acid sequence motifs typical of ATPase and RNA helicase proteins. In order to examine the RNA helicase activity of the HGV NS3 protein, the NS3 region (amino acids 904 to 1580) was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1035509bbeff6e27f5c423dc0341cb8
https://doi.org/10.1128/jvi.73.4.2909-2915.1999
https://doi.org/10.1128/jvi.73.4.2909-2915.1999
Publikováno v:
ResearcherID
The carboxyl-terminal three-fourths of the hepatitis C virus (HCV) NS3 protein has been shown to possess an RNA helicase activity, typical of members of the DEAD box family of RNA helicases. In addition, the NS3 protein contains four amino acid motif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5753fa1709d0391e26094bb2222c39a
https://doi.org/10.1128/jvi.71.12.9400-9409.1997
https://doi.org/10.1128/jvi.71.12.9400-9409.1997
Publikováno v:
Virus Research. 49:17-25
Hepatitis C virus (HCV) possesses two separate enzymatic functions in the NS3 protein: a protease and an NTPase/RNA helicase. In order to determine the minimal domain for NTPase and RNA helicase activities of the HCV NS3 protein, serial deletion muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99f5deece8860b7da667b1e58cc1a8f
https://doi.org/10.1016/s0168-1702(97)01452-4
https://doi.org/10.1016/s0168-1702(97)01452-4
Publikováno v:
Biochemical and Biophysical Research Communications. 225:654-659
The Hepatitis C Virus (HCV) NS3 protein has RNA binding activity, RNA-stimulated NTPase activity, and RNA helicase activity. The RNA binding activity of the C-terminal domain of the HCV NS3 protein is less sensitive to pH, KCl, and MgCl2than NTPase a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3ca9f6bb1a9aa0406d9e7166ddf92f
https://doi.org/10.1006/bbrc.1996.1225
https://doi.org/10.1006/bbrc.1996.1225
Publikováno v:
Journal of Virology. 77:810-812
RNA interference (RNAi) is a process of posttranscriptional gene silencing in plants, insects, and animals (4, 7, 13, 14). In vivo, RNAi is initiated by an endonuclease, DICER, that cleaves long, double-stranded RNA into 21- to 25-bp small interferin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6d6f726d8e3073d9189be9ff2ab2d3
https://doi.org/10.1128/jvi.77.1.810-812.2003
https://doi.org/10.1128/jvi.77.1.810-812.2003
Autor:
Jang H. Han, Paola Rinella, Ranjit Ray, Domenico Rosa, Michael Houghton, David Chien, Adrian M. Di Bisceglie, Viola Schultze, Heather Hill, Mark Wolff, Bruce F. Scharschmidt, Robert B. Belshe, Sharon E. Frey, Sergio Abrignani, Stephen R. Coates, Piero Pileri
Background Hepatitis C virus (HCV) causes chronic liver disease that often leads to cirrhosis and hepatocellular carcinoma. In animal studies, chimpanzees were protected against chronic infection following experimental challenge with either homologou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a495941cec29608a4f8c986bed0240b7
https://europepmc.org/articles/PMC2923449/
https://europepmc.org/articles/PMC2923449/
Publikováno v:
Virology. 191:889-899
Hepatitis C virus (HCV) is a distant relative of pestiviruses and flaviviruses, but it has a 5' untranslated region (UTR) with some features structurally similar to that of picornaviruses. In order to test the role of the 5' UTR in controlling the ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500c1323ae73cf3baedd3e947bc002c2
https://doi.org/10.1016/0042-6822(92)90264-p
https://doi.org/10.1016/0042-6822(92)90264-p
Autor:
Ferruccio Bonino, Kevin Crawford, Kathy H. Richman, James W. Tung, Amy J. Weiner, Q L Choo, Jody Rosenblatt, Matthew J. Brauer, Giorgio Maria Saracco, Michael Houghton, Jang H. Han
Publikováno v:
Virology. 180:842-848
Based on the flavi- and pestivirus model of genome organization for the hepatitis C virus (HCV) (1-5), the nucleotide and deduced amino acid sequences of the putative envelope (E1) and the junction between the E1 and NS1/envelope 2 (E2) region from s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7f0196442baad2b7e34e15275eb621
https://doi.org/10.1016/0042-6822(91)90104-j
https://doi.org/10.1016/0042-6822(91)90104-j