Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Janez Ilaš"'
Autor:
Dávid Bajusz, Warren S. Wade, Grzegorz Satała, Andrzej J. Bojarski, Janez Ilaš, Jessica Ebner, Florian Grebien, Henrietta Papp, Ferenc Jakab, Alice Douangamath, Daren Fearon, Frank von Delft, Marion Schuller, Ivan Ahel, Amanda Wakefield, Sándor Vajda, János Gerencsér, Péter Pallai, György M. Keserű
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Fragment-based drug discovery employs screening of small polar compounds typically exhibiting low affinity towards protein targets. Here, the authors combine the use of protein-based binding pharmacophores with the theory of protein hotspots to devel
Externí odkaz:
https://doaj.org/article/95bb508cd6554e5ea43dd584b6c41ad1
Autor:
Andrej Emanuel Cotman, Thomas Guérin, Ivana Kovačević, Davide Benedetto Tiz, Martina Durcik, Federica Fulgheri, Štefan Možina, Daniela Secci, Maša Sterle, Janez Ilaš, Anamarija Zega, Nace Zidar, Lucija Peterlin Mašič, Tihomir Tomašič, Frédéric R. Leroux, Gilles Hanquet, Danijel Kikelj
Publikováno v:
ACS Omega, Vol 6, Iss 14, Pp 9723-9730 (2021)
Externí odkaz:
https://doaj.org/article/9ba5d039df7149c1b22ceb9e931835a8
Autor:
Martina Durcik, Žan Toplak, Nace Zidar, Janez Ilaš, Anamarija Zega, Danijel Kikelj, Lucija Peterlin Mašič, Tihomir Tomašič
Publikováno v:
ACS Omega, Vol 5, Iss 14, Pp 8305-8311 (2020)
Externí odkaz:
https://doaj.org/article/4f43a3afa9774ebfa4eb99fa7ffa431e
Autor:
Péter Ábrányi-Balogh, Aaron Keeley, György G. Ferenczy, László Petri, Tímea Imre, Katarina Grabrijan, Martina Hrast, Damijan Knez, Janez Ilaš, Stanislav Gobec, György M. Keserű
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1484 (2022)
Heterocyclic electrophiles as small covalent fragments showed promising inhibitory activity on the antibacterial target MurA (UDP-N-acetylglucosamine 1-carboxyvinyltransferase, EC:2.5.1.7). Here, we report the second generation of heterocyclic electr
Externí odkaz:
https://doaj.org/article/df22a37fca3f4388a828d755b3209126
Autor:
Akos Nyerges, Tihomir Tomašič, Martina Durcik, Tamas Revesz, Petra Szili, Gabor Draskovits, Ferenc Bogar, Žiga Skok, Nace Zidar, Janez Ilaš, Anamarija Zega, Danijel Kikelj, Lejla Daruka, Balint Kintses, Balint Vasarhelyi, Imre Foldesi, Diána Kata, Martin Welin, Raymond Kimbung, Dorota Focht, Lucija Peterlin Mašič, Csaba Pal
Publikováno v:
PLoS Biology, Vol 18, Iss 10, p e3000819 (2020)
Antibiotics that inhibit multiple bacterial targets offer a promising therapeutic strategy against resistance evolution, but developing such antibiotics is challenging. Here we demonstrate that a rational design of balanced multitargeting antibiotics
Externí odkaz:
https://doaj.org/article/695667e264814dc5919d30b833577001
Autor:
Tihomir Tomašič, Asta Zubrienė, Žiga Skok, Riccardo Martini, Stane Pajk, Izidor Sosič, Janez Ilaš, Daumantas Matulis, Sharon D. Bryant
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 789 (2021)
DNA gyrase is an important target for the development of novel antibiotics. Although ATP-competitive DNA gyrase (GyrB) inhibitors are a well-studied class of antibacterial agents, there is currently no representative used in therapy, largely due to u
Externí odkaz:
https://doaj.org/article/ee00a302a11a4640be8c346b13958e36
Autor:
Martina Durcik, Žiga Skok, Janez Ilaš, Nace Zidar, Anamarija Zega, Petra Éva Szili, Gábor Draskovits, Tamás Révész, Danijel Kikelj, Akos Nyerges, Csaba Pál, Lucija Peterlin Mašič, Tihomir Tomašič
Publikováno v:
Pharmaceutics, Vol 13, Iss 1, p 6 (2020)
The discovery of multi-targeting ligands of bacterial enzymes is an important strategy to combat rapidly spreading antimicrobial resistance. Bacterial DNA gyrase and topoisomerase IV are validated targets for the development of antibiotics. They can
Externí odkaz:
https://doaj.org/article/b21ef8c08f5f42f5bcc65fa01c759cd9
Publikováno v:
Pharmaceutics, Vol 12, Iss 7, p 639 (2020)
Venetoclax is an orally bioavailable, B-cell lymphoma-2 (BCL-2) selective inhibitor, used for the treatment of various types of blood cancers, such as chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). In this study we investiga
Externí odkaz:
https://doaj.org/article/6d416e0b76d343bd87be443c869a3f74
Autor:
Steve Peigneur, Aleš Žula, Nace Zidar, Fiona Chan-Porter, Robert Kirby, David Madge, Janez Ilaš, Danijel Kikelj, Jan Tytgat
Publikováno v:
Marine Drugs, Vol 12, Iss 4, Pp 2132-2143 (2014)
Clathrodin is a marine alkaloid and believed to be a modulator of voltage-gated sodium (NaV) channels. Since there is an urgent need for small molecule NaV channel ligands as novel therapeutics, clathrodin could represent an interesting lead compound
Externí odkaz:
https://doaj.org/article/ae4d9687a1d8427f8427040fc63d88ca
Publikováno v:
ARKIVOC, Vol 2011, Iss 10, Pp 309-322 (2011)
Externí odkaz:
https://doaj.org/article/d1a43930229841f4aeecbad00db72aa5