Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Janey Ronxhi"'
Autor:
Qiang Shi, Ayesha Arefin, Lijun Ren, Katy S. Papineau, Dustyn A. Barnette, Laura K. Schnackenberg, Jessica J. Hawes, Mark Avigan, Donna L. Mendrick, Lorna Ewart, Janey Ronxhi
Publikováno v:
Current Protocols. 2
Drug-induced liver injury (DILI) is a significant public health issue, but standard animal tests and clinical trials sometimes fail to predict DILI due to species differences and the relatively low number of human subjects involved in preapproval stu
Assessment of Human Renal Transporter Based Drug-Drug Interactions Using Proximal Tubule Kidney-Chip
Autor:
Anantha Ram Nookala, Janey Ronxhi, Josiah Sliz, Sauvear Jeanty, Dimitris V. Manatakis, Sushma Jadalannagari, Geraldine Hamilton, Hyoungshin Park, Yu He, Mitchell Lavarias, Gang Luo, Kyung-Jin Jang, Donald Mckenzie
Study of renal transporters is crucial for understanding drug disposition and toxicity, and more importantly, predicting potential drug-drug interactions (DDIs). However, conventional in vitro models often fail to predict renal transporter activity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddeac2c41070191c706604d26329663f
https://doi.org/10.1101/2022.05.12.491717
https://doi.org/10.1101/2022.05.12.491717
Autor:
Dominic P. Williams, Pedro Caetano-Pinto, Janey Ronxhi, Beate Ehrhardt, Geraldine A. Hamilton, Lorna Ewart, Alison J. Foster, Samantha Peel, Konstantia Kodella, Matthew Boeckeler, Kyung-Jin Jang, Debora B. Petropolis, Adam Corrigan, Jonathan E. Rubins, Gauri Kulkarni
Publikováno v:
Peel, S, Corrigan, A M, Ehrhardt, B, Jang, K-J, Caetano-Pinto, P, Boeckeler, M, Rubins, J E, Kodella, K, Petropolis, D B, Ronxhi, J, Kulkarni, G, Foster, A J, Williams, D, Hamilton, G A & Ewart, L 2019, ' Introducing an automated high content confocal imaging approach for Organs-on-Chips ', Lab on a Chip, vol. 19, no. 3, pp. 410-421 . https://doi.org/10.1039/c8lc00829a
Organ-Chips are micro-engineered systems that aim to recapitulate the organ microenvironment. Implementation of Organ-Chips within the pharmaceutical industry aims to improve the probability of success of drugs reaching late stage clinical trial by g
Autor:
K. Karalis, Janey Ronxhi, Janna Nawroth, Dimitris V. Manatakis, Ekihiro Seki, Anke Witt, Gauri Kulkarni, Gabriel Burchett, Abhishek Shukla, Shelly C. Lu, Geraldine A. Hamilton, Katharina Schlünder, Tengku Ibrahim Maulana, Konstantia Kodella, Debora B. Petropolis
Publikováno v:
Cell reports
Cell reports, vol 36, iss 3
Cell reports, vol 36, iss 3
SUMMARY Alcohol-associated liver disease (ALD) is a global health issue and leads to progressive liver injury, comorbidities, and increased mortality. Human-relevant preclinical models of ALD are urgently needed. Here, we leverage a triculture human
Autor:
Erio Barale, Katia Karalis, Riccardo Barrile, Kyung-Jin Jang, Monica Singer, Abhishek Srivastava, Anna Herland, Josiah Sliz, Barry Jones, Hyoungshin Park, Janna Nawroth, Geraldine A. Hamilton, Dominic P. Williams, Wing W. Lam, Gauri Kulkarni, Jonathan E. Rubins, Suzzette Haney, Linda C. Andersson, Manisha Sonee, Konstantia Kodella, Debora B. Petropolis, Monicah A. Otieno, Heng-Keang Lim, Lorna Ewart, Bhanu Singh, Carl L. Manthey, Janey Ronxhi, Donald E. Ingber, David Conegliano, Anthony J. Streeter, Damir Simic
Nonclinical rodent and non-rodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans contributing to drug failures in the clinic. Here we applied microengineere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77153c2fec6be0820279936c4ea70992
Autor:
Bhanu Singh, Suzzette Haney, Carl L. Manthey, Riccardo Barrile, Anna Herland, Dominic P. Williams, Manisha Sonee, Katia Karalis, Monica Singer, David Conegliano, Heng-Keang Lim, Geraldine A. Hamilton, Donald E. Ingber, Monicah A. Otieno, Anthony J. Streeter, Lorna Ewart, Erio Barale, Linda C. Andersson, Barry Jones, Wing W. Lam, Damir Simic, Konstantia Kodella, Debora B. Petropolis, Josiah Sliz, Janey Ronxhi, Janna Nawroth, Abhishek Srivastava, Kyung-Jin Jang, Gauri Kulkarni, Hyoungshin Park, Jonathan E. Rubins
Publikováno v:
Science translational medicine. 11(517)
Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans, contributing to drug failures in the clinic. Here, we applied microengineer
Autor:
W. Lam, Monica Singer, Heng-Keang Lim, Gauri Kulkarni, Monicah A. Otieno, Konstantia Kodella, Janey Ronxhi, Debora B. Petropolis, J. Chen, P. Guzzie-Peck, Damir Simic, Jonathan E. Rubins, K. Karalis, Kyung-Jin Jang, Geraldine A. Hamilton
Publikováno v:
Toxicology Letters. 295:S129-S130