Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Janey N. Parsons"'
Autor:
Susan Cupo, John S. Mudgett, Nicole A. Chartrain, Karen Lowitz, Catherine E. Fitzgerald, Dennis M. Zaller, Ester Carballo-Jane, Stephen J. O'Keefe, Silvi Luell, Cordelia Rasa, Karen Owens, Shiow-Ling Chen, Denise M. Visco, Janey N. Parsons
Publikováno v:
Journal of Biological Chemistry. 282:34663-34671
The p38 MAP kinase signal transduction pathway is an important regulator of proinflammatory cytokine production and inflammation. Defining the roles of the various p38 family members, specifically p38alpha and p38beta, in these processes has been dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdd43cddde72b5f75a9b11bba35774d
https://doi.org/10.1074/jbc.m704236200
https://doi.org/10.1074/jbc.m704236200
Autor:
Janey N. Parsons, Michael J. Tocci, Stephen J. O'Keefe, Margaret Pang, Hollis R. Williams, Betsy Frantz, Tracey Klatt, Anna M. Rolando, Edward A. O'Neill
Publikováno v:
Biochemistry. 37:13846-13853
The serine/threonine kinase p38 is a ubiquitous, highly conserved, stress responsive, signal-transducing enzyme. It regulates the production of proinflammatory mediators and is the target of the cytokine synthesis inhibitory pyridinylimidazoles. We h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d084600d9d6efef50916e92dc2072085
https://doi.org/10.1021/bi980832y
https://doi.org/10.1021/bi980832y
A TACROLIMUS-RELATED IMMUNOSUPPRESSANT WITH BIOCHEMICAL PROPERTIES DISTINCT FROM THOSE OF TACROLIMUS
Autor:
Mary M. Martin, Laurence B. Peterson, Gregory J. Wiederrecht, Janey N. Parsons, William H. Parsons, Peter J. Sinclair, Mary Beth Wilusz, Frederick Wong, John G. Cryan, Stephen J. O'Keefe, Matthew J. Wyvratt, Ray Rosa, Nolan H. Sigal, Alan R. Williamson
Publikováno v:
Transplantation. 65:10-18
Background Tacrolimus (FK506) is an immunosuppressive drug 50-100 times more potent than cyclosporine (CsA), the current mainstay of organ transplant rejection therapy. Despite being chemically unrelated, CsA and tacrolimus exert their immunosuppress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d629f9f28c4924d99389136bd19b5cd
https://doi.org/10.1097/00007890-199801150-00004
https://doi.org/10.1097/00007890-199801150-00004
Publikováno v:
Protein Expression and Purification. 6:655-664
Calcineurin, a protein phosphatase found in eukaryotic cells, presents a challenging problem in heterologous protein expression because it is both heterodimeric and posttranslationally modified. In this paper, we describe the cloning of both subunits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307d122f057538ce3dc709a86755bcee
https://doi.org/10.1006/prep.1995.1086
https://doi.org/10.1006/prep.1995.1086
Autor:
L L Rokosz, J J Burbaum, Janey N. Parsons, Scott P. Salowe, Gregory J. Wiederrecht, Stephen J. O'Keefe, R L Kincaid
Publikováno v:
Journal of Biological Chemistry. 269:19610-19616
The immunosuppressant FK-506 (tacrolimus) forms a complex with a ubiquitous intracellular receptor, FK-506 binding protein (FKBP12), and this complex inhibits the heterodimeric Ca2+/calmodulin-dependent phosphatase, calcineurin, an essential componen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea498aaa8cfdff1e2b5e2bf50f949cba
https://doi.org/10.1016/s0021-9258(17)32213-5
https://doi.org/10.1016/s0021-9258(17)32213-5
Autor:
Malcolm MacCoss, Stephen E. de Laszlo, Nathan B. Mantlo, Bing Li, Candice Hacker, Janey N. Parsons, W.Rick Widmer, Matthew J. Kostura, Anna M. Rolando, Betsy Frantz, Gist Croft, Chad Orevillo, Yousif S Sahly, Amy Forsyth, William A. Hanlon, Linda Chang, Jayne Chin, Stephen J. O'Keefe, Edward A. O'Neill, Denise M. Visco, Kelley Sidler, Daniel S. Fletcher, Coral Harper, Lily Agarwal, Margaret Pang, Sylvie Luell
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(19)
Investigation of furans, pyrroles and pyrazolones identified 3-pyridyl-2,5-diaryl-pyrroles as potent, orally bioavailable inhibitors of p38 kinase. 3-(4-pyridyl-2-(4-fluoro-phenyl)-5-(4-methylsulfinylphenyl)-pyrrole (L-167307) reduces secondary paw s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e7828db91d45cd011ad0eb4c9f26a6
https://pubmed.ncbi.nlm.nih.gov/9873604
https://pubmed.ncbi.nlm.nih.gov/9873604
Autor:
Alan D. Schreiber, Janey N. Parsons
Publikováno v:
The Journal of Immunology. 118:1119-1121
Levamisole, an isomer of tetrahydro phenylimidazo thiazole, is a synthetic anti-helminthic which may have immunostimulating properties both in vivo and in vitro (1). Its mode of action is incompletely understood. There is evidence in murine systems t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8077e0cb23f34f0ea9d5283b5a8cb7e5
https://doi.org/10.4049/jimmunol.118.3.1119
https://doi.org/10.4049/jimmunol.118.3.1119