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of 6
pro vyhledávání: '"Janette Robertson"'
Autor:
Raul de la Flor, Janette Robertson, Rostislav V. Shevchenko, Mo Alavijeh, Sean Bickerton, Tarek Fahmy, Su M. Metcalfe
Publikováno v:
Frontiers in Medical Technology, Vol 3 (2021)
Multiple sclerosis (MS) is a demyelinating autoimmune disease that attacks the brain, with year-on-year loss of brain volume, starting late teens and becoming manifest late twenties. There is no cure, and current therapies are immunosuppressive only.
Externí odkaz:
https://doaj.org/article/9f50990e73424ad8a542664ee3dc40ce
Autor:
Michal Mielcarek, Christian Landles, Andreas Weiss, Amyaouch Bradaia, Tamara Seredenina, Linda Inuabasi, Georgina F Osborne, Kristian Wadel, Chrystelle Touller, Rachel Butler, Janette Robertson, Sophie A Franklin, Donna L Smith, Larry Park, Paul A Marks, Erich E Wanker, Eric N Olson, Ruth Luthi-Carter, Herman van der Putten, Vahri Beaumont, Gillian P Bates
Publikováno v:
PLoS Biology, Vol 11, Iss 11, p e1001717 (2013)
Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine-rich domain. We hypothesised that it may be involved in the molecular pathogenesis of Huntington's disease (HD), a protein-folding neurodegenerative disorder caused
Externí odkaz:
https://doaj.org/article/36f0a78b62114715a37984063f3cb2d9
Autor:
Raul de la Flor, Janette Robertson, Mo Alavijeh, Tarek M. Fahmy, Sean Bickerton, Su M. Metcalfe, Rostislav V. Shevchenko
Publikováno v:
Frontiers in Medical Technology
Frontiers in Medical Technology, Vol 3 (2021)
Frontiers in Medical Technology, Vol 3 (2021)
Multiple sclerosis (MS) is a demyelinating autoimmune disease that attacks the brain, with year-on-year loss of brain volume, starting late teens and becoming manifest late twenties. There is no cure, and current therapies are immunosuppressive only.
Autor:
Gillian P. Bates, Janette Robertson, Herman van der Putten, Christian Landles, Tamara Seredenina, Michal Mielcarek, Erich E. Wanker, Chrystelle Touller, Andreas Weiss, Paul A. Marks, Sophie A. Franklin, Vahri Beaumont, Donna L. Smith, Amyaouch Bradaia, Rachel Butler, Georgina F. Osborne, Kristian Wadel, Linda Inuabasi, Larry Park, Eric N. Olson, Ruth Luthi-Carter
Publikováno v:
PLoS Biology
PLoS Biology, Vol 11, Iss 11, p e1001717 (2013)
PLoS Biology, Vol 11, Iss 11, p e1001717 (2013)
HDAC4 histone deacetylase is found to associate with huntingtin in a polyQ-length dependent manner. Reduction of HDAC4 levels in mouse models of Huntington's disease (HD) delays cytoplasmic aggregation in the brain and improves the molecular patholog
Autor:
Jonathan Papworth, Alexander Syme, Anthony Groom, Adam Lucas, Lee Dawson, Toshal Patel, Janette Robertson, Jane Gartlon
Publikováno v:
Alzheimer's & Dementia. 8
dementia. Conclusions: Our findings indicate that following cardiac surgery the number of individuals identified as at risk of dementia is much higher than expected in the general population (0.3-0.8% per year) as more than 50% of individuals were af
Autor:
Samantha Calvert, Lee A. Dawson, Toshal Patel, Anthony Groom, Janette Robertson, Jonathan Papworth, Jane Gartlon
Publikováno v:
Alzheimer's & Dementia. 8
However, APP transgenic mice over express APP and even though FADmutations ensures high production of As species the by-products sAPP and intracellular domain of APP (AICD) are also generated, both of which have physiological functions. This leads to