Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Janette Lloyd"'
Autor:
Otto J.P. Kyrieleis, Pauline B. McIntosh, Sarah R. Webb, Lesley J. Calder, Janette Lloyd, Nisha A. Patel, Stephen R. Martin, Carol V. Robinson, Peter B. Rosenthal, Stephen J. Smerdon
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3099-3106 (2016)
BRCA1 is a tumor suppressor found to be mutated in hereditary breast and ovarian cancer and plays key roles in the maintenance of genomic stability by homologous recombination repair. It is recruited to damaged chromatin as a component of the BRCA1-A
Externí odkaz:
https://doaj.org/article/f2309bca943b435cac90ed30c0bcf62c
Publikováno v:
Research and Practice in Intellectual and Developmental Disabilities. 9:5-13
Autor:
Pauline B. McIntosh, Stephen R. Martin, Sarah R. Webb, O.J.P. Kyrieleis, Carol V. Robinson, Peter B. Rosenthal, Lesley J. Calder, Janette Lloyd, Stephen J. Smerdon, Nisha A. Patel
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3099-3106 (2016)
Cell Reports
Cell Reports
Summary BRCA1 is a tumor suppressor found to be mutated in hereditary breast and ovarian cancer and plays key roles in the maintenance of genomic stability by homologous recombination repair. It is recruited to damaged chromatin as a component of the
Autor:
Sarah L. Maslen, Jean-Yves Bleuyard, Stephen J. Smerdon, Mark Skehel, Fumiko Esashi, Janette Lloyd, Keiko Yata
Publikováno v:
Molecular Cell. 45(3):371-383
Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and G2 phases of the cell cycle but its regulatory mechanisms remain elusive. Here, we report that Polo-like kinase 1 (Plk1),
A Supramodular FHA/BRCT-Repeat Architecture Mediates Nbs1 Adaptor Function in Response to DNA Damage
Autor:
Edgar Hartsuiker, Stephen J. Smerdon, Jiejin Li, Lesley F. Haire, Janette Lloyd, J. Ross Chapman, Antony M. Carr, Stephen P. Jackson, Julie A. Clapperton
Publikováno v:
Cell; Vol 139
SummaryThe Mre11/Rad50/Nbs1 protein complex plays central enzymatic and signaling roles in the DNA-damage response. Nuclease (Mre11) and scaffolding (Rad50) components of MRN have been extensively characterized, but the molecular basis of Nbs1 functi
Autor:
Janette Lloyd, Derek Macmillan, Steven Howell, Stephen J. Smerdon, Jiejin Li, Ian A. Taylor, Julie A. Clapperton
Publikováno v:
Journal of Biological Chemistry. 283:36019-36030
Chk2/CHEK2/hCds1 is a modular serine-threonine kinase involved in transducing DNA damage signals. Phosphorylation by ataxia telangiectasia-mutated kinase (ATM) promotes Chk2 self-association, autophosphorylation, and activation. Here we use expressed
Autor:
Mario Bonalli, Lucijana Pavic, Lesley F. Haire, Dorthe Helena Larsen, Jiejin Li, Julie A. Clapperton, Stephen J. Smerdon, Christoph Spycher, Michael L. Nielsen, Flurina J. Hari, Janette Lloyd, Claudia Lukas, Stephanie Jungmichel, Manuel Stucki, Derek Macmillan, J Lukas
Publikováno v:
Nucleic Acids Research
Nucleic acids research
Nucleic acids research
Mdc1 is a large modular phosphoprotein scaffold that maintains signaling and repair complexes at double-stranded DNA break sites. Mdc1 is anchored to damaged chromatin through interaction of its C-terminal BRCT-repeat domain with the tail of γH2AX f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd7d26bde6c8eb127b503f01ef4252a
https://www.zora.uzh.ch/id/eprint/74315/
https://www.zora.uzh.ch/id/eprint/74315/
Autor:
Jiejin, Li, Ian A, Taylor, Janette, Lloyd, Julie A, Clapperton, Steven, Howell, Derek, MacMillan, Stephen J, Smerdon
Publikováno v:
The Journal of biological chemistry. 283(51)
Chk2/CHEK2/hCds1 is a modular serine-threonine kinase involved in transducing DNA damage signals. Phosphorylation by ataxia telangiectasia-mutated kinase (ATM) promotes Chk2 self-association, autophosphorylation, and activation. Here we use expressed