Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Janette K Burgess"'
Autor:
Karryn T Grafton, Lyn M Moir, Judith L Black, Nicole G Hansbro, Philip M Hansbro, Janette K Burgess, Brian G Oliver
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85655 (2014)
BackgroundTumstatin is a segment of the collagen-IV protein that is markedly reduced in the airways of asthmatics. Tumstatin can play an important role in the development of airway remodelling associated with asthma due to its anti-angiogenic propert
Externí odkaz:
https://doaj.org/article/059d0ec733d9435892adfc513cf752be
Autor:
Nessa Banville, Janette K Burgess, Jade Jaffar, Gavin Tjin, Luca Richeldi, Stefania Cerri, Elisa Persiani, Judith L Black, Brian G Oliver
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105365 (2014)
Lymphangioleiomyomatosis (LAM) is a rare and progressive cystic lung condition affecting approximately 3.4-7.5/million women, with an average lag time between symptom onset and diagnosis of upwards of 4 years. The aim of this work was to identify alt
Externí odkaz:
https://doaj.org/article/4af9af2ec73e45d08c84b37b0e264465
Autor:
Rosa K. Kortekaas, Kerstin E. Geillinger-Kästle, Rocío Fuentes-Mateos, Roël van Orsoy, Nakaa Al-Alyan, Janette K. Burgess, Reinoud Gosens
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionExacerbations of chronic obstructive pulmonary disease (COPD) increase mortality risk and can lead to accelerated loss of lung function. The increased inflammatory response during exacerbations contributes to worsening of airflow limitati
Externí odkaz:
https://doaj.org/article/f490fd823a3d4df79534252d7f20c695
Autor:
David Van Ly, Alen Faiz, Christine Jenkins, Ben Crossett, Judith L Black, Brent McParland, Janette K Burgess, Brian G G Oliver
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56058 (2013)
Rhinovirus (RV) infections account for approximately two thirds of all virus-induced asthma exacerbations and often result in an impaired response to β2 agonist therapy. Using an in vitro model of RV infection, we investigated the mechanisms underly
Externí odkaz:
https://doaj.org/article/0b7931eb10c44f7d82117f181d73dadd
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65544 (2013)
Fibulin-1 (FBLN-1) is a secreted glycoprotein that is associated with extracellular matrix (ECM) formation and rebuilding. Abnormal and exaggerated deposition of ECM proteins is a hallmark of many fibrotic diseases, such as chronic obstructive pulmon
Externí odkaz:
https://doaj.org/article/c676cf90d28b4c5ea686dcd152ddcea5
Autor:
Alen Faiz, Gavin Tjin, Louise Harkness, Markus Weckmann, Shisan Bao, Judith L Black, Brian G G Oliver, Janette K Burgess
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57245 (2013)
Tumstatin is an anti-angiogenic collagen IV α3 fragment, levels of which are reduced in the airways of asthmatics. Its reduction may be due to the degradation by extracellular matrix (ECM) proteases. Cathepsins play a role in ECM remodelling, with c
Externí odkaz:
https://doaj.org/article/773520963db848a391ec73e7b1113f90
Autor:
Roderick H. J. de Hilster, Marjan A. Reinders-Luinge, Annemarie Schuil, Theo Borghuis, Martin C. Harmsen, Janette K. Burgess, Machteld N. Hylkema
Publikováno v:
Bioengineering, Vol 11, Iss 9, p 946 (2024)
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by ongoing inflammation, impaired tissue repair, and aberrant interplay between airway epithelium and fibroblasts, resulting in an altered extracellular matrix (ECM)
Externí odkaz:
https://doaj.org/article/3df3b1d0ed8145518b10d63a49ca5e37
Autor:
Thomas Trian, Janette K Burgess, Kyoko Niimi, Lyn M Moir, Qi Ge, Patrick Berger, Stephen B Liggett, Judith L Black, Brian G Oliver
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20000 (2011)
Asthma is associated with airway narrowing in response to bronchoconstricting stimuli and increased airway smooth muscle (ASM) mass. In addition, some studies have suggested impaired β-agonist induced ASM relaxation in asthmatics, but the mechanism
Externí odkaz:
https://doaj.org/article/294b14fb858d4923bcca8f608b5fb2b8
Autor:
Justine Y Lau, Brian G Oliver, Melissa Baraket, Emma L Beckett, Nicole G Hansbro, Lyn M Moir, Steve D Wilton, Carolyn Williams, Paul S Foster, Philip M Hansbro, Judith L Black, Janette K Burgess
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13360 (2010)
BACKGROUND: The extracellular matrix is a dynamic and complex network of macromolecules responsible for maintaining and influencing cellular functions of the airway. The role of fibronectin, an extracellular matrix protein, is well documented in asth
Externí odkaz:
https://doaj.org/article/ddc794eb15104c2bb96d4b448d663262
Autor:
Mehmet Nizamoglu, Maunick Lefin Koloko Ngassie, Rhode A. Meuleman, Martin Banchero, Theo Borghuis, Wim Timens, Martijn C. Nawijn, Barbro N. Melgert, Irene H. Heijink, Corry-Anke Brandsma, Janette K. Burgess
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Abnormal deposition of extracellular matrix (ECM) in lung tissue is a characteristic of idiopathic pulmonary fibrosis (IPF). Increased collagen deposition is also accompanied by altered collagen organization. Collagen type XIV, a fibril-asso
Externí odkaz:
https://doaj.org/article/a8279a64c37149c6829e8aef79c36513