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pro vyhledávání: '"Janette Holtz"'
Autor:
Janette Holtz, Amy E. Pasquinelli
Publikováno v:
RNA. 15:400-405
In animals, microRNAs (miRNAs), typically, pair to sites of partial complementarity in the 3′-untranslated regions (3′UTRs) of target genes. Regulation by miRNAs often results in down-regulation of target mRNA and protein expression by mechanisms
Autor:
Shveta Bagga, Amy E. Pasquinelli, Katlin B. Massirer, Shaun Hunter, John R. Bracht, Janette Holtz, Rachel Eachus
Publikováno v:
Cell. 122(4):553-563
Summary MicroRNAs (miRNAs) are ∼22 nucleotide RNAs that negatively regulate the expression of protein-coding genes. In a present model of miRNA function in animals, miRNAs that form imperfect duplexes with their targets inhibit protein expression w
Publikováno v:
Freshwater Biology. 49:221-231
SUMMARY 1. Ephemeral wetland habitats provide a useful model system for studying how lifehistory patterns enable populations to persist despite high environmental variation. One important life-history trait of both plants and crustaceans in such habi
Publikováno v:
BMC Genomics
BMC Genomics, Vol 8, Iss 1, p 445 (2007)
Norden-Krichmar, TM; Holtz, J; Pasquinelli, AE; & Gaasterland, T. (2007). Computational prediction and experimental validation of Ciona intestinalis microRNA genes. BMC Genomics, 8. doi: 10.1186/1471-2164-8-445. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9bt2k7pk
BMC Genomics, Vol 8, Iss 1, p 445 (2007)
Norden-Krichmar, TM; Holtz, J; Pasquinelli, AE; & Gaasterland, T. (2007). Computational prediction and experimental validation of Ciona intestinalis microRNA genes. BMC Genomics, 8. doi: 10.1186/1471-2164-8-445. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9bt2k7pk
Background This study reports the first collection of validated microRNA genes in the sea squirt, Ciona intestinalis. MicroRNAs are processed from hairpin precursors to ~22 nucleotide RNAs that base pair to target mRNAs and inhibit expression. As a m