Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Janette Heegsma"'
Autor:
Defu Kong, Apostolos Mourtzinos, Janette Heegsma, Hans Blokzijl, Vincent E. de Meijer, Klaas Nico Faber
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Background and aim Liver fibrosis is prevalent among chronic diseases of the liver and represents a major health burden worldwide. Growth differentiation factor 7 (GDF7), a member of the TGFβ protein superfamily, has been recently investiga
Externí odkaz:
https://doaj.org/article/247aa6197a6a4e9e824f186fdb96d24d
Autor:
Natalia Smith-Cortinez, Janette Heegsma, Masa Podunavac, Armen Zakarian, J. César Cardenas, Klaas Nico Faber
Publikováno v:
Cells, Vol 13, Iss 9, p 765 (2024)
Liver fibrosis, characterized by excessive extracellular matrix (ECM) deposition, can progress to cirrhosis and increases the risk of liver cancer. Hepatic stellate cells (HSCs) play a pivotal role in fibrosis progression, transitioning from a quiesc
Externí odkaz:
https://doaj.org/article/9419861a9864418eae60492552874668
Autor:
Archibold Mposhi, Fabian Cortés-Mancera, Janette Heegsma, Vincent E. de Meijer, Bart van de Sluis, Svenja Sydor, Lars P. Bechmann, Claudia Theys, Peter de Rijk, Tim De Pooter, Wim Vanden Berghe, İkbal Agah İnce, Klaas Nico Faber, Marianne G. Rots
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
IntroductionHepatic lipid accumulation and mitochondrial dysfunction are hallmarks of metabolic associated fatty liver disease (MAFLD), yet molecular parameters underlying MAFLD progression are not well understood. Differential methylation within the
Externí odkaz:
https://doaj.org/article/1824ad711d384cc69785ea814dba5292
Autor:
Ali Saeed, Paulina Bartuzi, Janette Heegsma, Daphne Dekker, Niels Kloosterhuis, Alain de Bruin, Johan W. Jonker, Bart van de Sluis, Klaas Nico Faber
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 309-325.e3 (2021)
Background & Aims: Systemic retinol (vitamin A) homeostasis is controlled by the liver, involving close collaboration between hepatocytes and hepatic stellate cells (HSCs). Genetic variants in retinol metabolism (PNPLA3 and HSD17B13) are associated w
Externí odkaz:
https://doaj.org/article/789c32ef59934821b9a56c45c87d197f
Autor:
Arno R. Bourgonje, Julius Z. H. von Martels, Ruben Y. Gabriëls, Tjasso Blokzijl, Manon Buist-Homan, Janette Heegsma, Bernadien H. Jansen, Hendrik M. van Dullemen, Eleonora A. M. Festen, Rinze W. F. ter Steege, Marijn C. Visschedijk, Rinse K. Weersma, Paul de Vos, Klaas Nico Faber, Gerard Dijkstra
Publikováno v:
Frontiers in Medicine, Vol 6 (2019)
Introduction: Blood C-reactive protein (CRP) and fecal calprotectin levels are routinely measured as surrogate markers of disease activity in Inflammatory Bowel Disease (IBD), but often do not correlate well with the degree of mucosal inflammation in
Externí odkaz:
https://doaj.org/article/1d1cd076e6874f9da502d2e2b1e1d725
Autor:
Natalia Smith-Cortinez, Karen van Eunen, Janette Heegsma, Sandra Alejandra Serna-Salas, Svenja Sydor, Lars P. Bechmann, Han Moshage, Barbara M. Bakker, Klaas Nico Faber
Publikováno v:
Cells, Vol 9, Iss 11, p 2456 (2020)
Upon liver injury, hepatic stellate cells (HSCs) transdifferentiate to migratory, proliferative and extracellular matrix-producing myofibroblasts (e.g., activated HSCs; aHSCs) causing liver fibrosis. HSC activation is associated with increased glycol
Externí odkaz:
https://doaj.org/article/4f63a63b61ac44c39649e83247d52df1
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88011 (2014)
BACKGROUND: Farnesoid X receptor/retinoid X receptor-alpha (FXR/RXRα) is the master transcriptional regulator of bile salt synthesis and transport in liver and intestine. FXR is activated by bile acids, RXRα by the vitamin A-derivative 9-cis retino
Externí odkaz:
https://doaj.org/article/bd4a694f1d784f09939ae53b15936d20
Autor:
Natalia Estrada‐Ortiz, Viktoriia Starokozhko, Hidde van Steenwijk, Cor van der Heide, Hjalmar Permentier, Lisanne van Heemskerk, Grietje Harmanna Prins, Janette Heegsma, Klaas Nico Faber, Steffi Bressers, Guy Steiblen, Antoinette de Groot, Steve Groome, Erik van Miert, Geny Groothuis, Inge Anne Maria de Graaf
Publikováno v:
Journal of Applied Toxicology, 42(12), 1921-1936. Wiley
The biocide tetrakis(hydroxymethyl)phosphonium sulphate (THPS) and other members of the tetrakis(hydroxymethyl) phosphonium salts (THPX) family are associated with liver toxicity in several mammalian species and teratogenicity in rabbits. Malformatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20091feedc3d29b00746d7591665a26b
https://doi.org/10.1002/jat.4364
https://doi.org/10.1002/jat.4364
Autor:
Defu Kong, Natalia Smith-Cortinez, Janette Heegsma, Hans Blokzijl, Vincent E de Meijer, Klaas Nico Faber
Background Liver regeneration is compromised in advanced fibrosis or cirrhosis, where progenitor cell therapy is being considered as a therapeutic option. Little is known about the presence and potential role of leucine-rich-repeat-containing G prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbf32052870986b6b0de8ead662af74
https://doi.org/10.21203/rs.3.rs-2613542/v1
https://doi.org/10.21203/rs.3.rs-2613542/v1
Autor:
Svenja Sydor, Natalia Smith-Cortinez, Janette Heegsma, Shiva Shajari, Ali Saeed, Klaas Nico Faber
Publikováno v:
Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1864(9), 1258-1267. ELSEVIER SCIENCE BV
Hepatic stellate cells (HSC) store vitamin A as retinyl esters and control circulating retinol levels. Upon liver injury, quiescent (q)HSC lose their vitamin A and transdifferentiate to myofibroblasts, e.g. activated (a)HSC, which promote fibrosis by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e1cafcaab3c0e6152ee7e7598758e9
https://research.rug.nl/en/publications/163b5fea-4b53-416b-9566-c29593a223a4
https://research.rug.nl/en/publications/163b5fea-4b53-416b-9566-c29593a223a4