Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Janette A. Thomas"'
Autor:
Janette A. Thomas, Burton Steven J, Wendy K. Alderton, Jennifer M. Pitts, Nicolas P. Burton, Christopher R. Lowe
Publikováno v:
Trends in Biotechnology. 10:442-448
Affinity chromatography has been extensively refined over the past few years to meet the more stringent criteria being placed on recombinant proteins as therapeutic products. New developments in the design of selective and stable ligands for affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1aba14dfa3bd9bdbd160f17705d3c20
https://doi.org/10.1016/0167-7799(92)90294-6
https://doi.org/10.1016/0167-7799(92)90294-6
Autor:
Gordon C. K. Roberts, John R. P. Arnold, Janette A. Thomas, James Feeney, J. Andrews, Berry Birdsall, Jaswir Basran
Publikováno v:
Protein engineering. 7(6)
A mutant of Lactobacillus casei dihydrofolate reductase has been constructed in which Thr63, a residue which interacts with the 2'-phosphate group of the bound coenzyme, is replaced by alanine. This substitution does not affect kcat, but produces an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628fde3349d704ad2a77b9ffaabd374c
https://pubmed.ncbi.nlm.nih.gov/7937709
https://pubmed.ncbi.nlm.nih.gov/7937709
Autor:
John R. P. Arnold, Mark D. Carr, S. J. B. Tendler, Berry Birdsall, Janette A. Thomas, James Feeney, Malcolm F. G. Stevens, R.J. Griffin, G. C. K. Roberts
Publikováno v:
Biochemistry. 29(41)
1H and 19F NMR signals from bound ligands have been assigned in one- and two-dimensional NMR spectra of complexes of Lactobacillus casei dihydrofolate reductase with various pyrimethamine analogues (including pyrimethamine [1, 2,4-diamino-5-(4'-chlor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69f9e3e05c30d39c9a0515ce6849123
https://pubmed.ncbi.nlm.nih.gov/2125479
https://pubmed.ncbi.nlm.nih.gov/2125479
Autor:
Gordon C. K. Roberts, S. J. B. Tendler, James Feeney, Christopher J. Bauer, Berry Birdsall, John R. P. Arnold, Jesús Jiménez-Barbero, Janette A. Thomas, Thomas A. Frenkiel, Mark D. Carr
Publikováno v:
European journal of biochemistry. 191(3)
All the aromatic proton resonances in the 500-MHz NMR spectra of Lactobacillus casei dihydrofolate reductase have been assigned for several of its complexes with inhibitors. For the complexes with methotrexate and trimethoprim this was achieved by us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3314d09c297da0dc7be45d24078fc3
https://pubmed.ncbi.nlm.nih.gov/2118112
https://pubmed.ncbi.nlm.nih.gov/2118112