Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Janette, Walters"'
Autor:
Dao Lentz, Marc Whitlow, Kenneth J. Shaw, Karna Lyn Sacchi, Sakata Steven T, Janette Walters, Kathy White, Joseph Post, Bin Ye, Wheeseong Lee, Kochanny Monica, Elena Ho, Amy Liang, Ron Vergona, Janice Ewing, Morrissey Michael M, Karanjawala Rushad E, Gary Phillips, Zuchun Zhao, Brian D. Griedel, Babu Subramanyam, Marc Adler
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:2127-2146
A series of thiophene-containing non-amidine factor Xa inhibitors is described. Simple methyl-substituted thiophene analogs were relatively weak inhibitors. However, introduction of hydrophilic substituents at C-4 or C-5 of the thiophene afforded inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b4b05420f1f0b4641803f66b53494f
https://doi.org/10.1016/j.bmc.2006.12.019
https://doi.org/10.1016/j.bmc.2006.12.019
Autor:
Amy Liang, Ron Vergona, Keith Eagen, Janette Walters, David J. Smith, Kenneth J. Shaw, Ng Howard P, Elena Ho, Dao Lentz, Kathy White, Lan Trinh, Babu Subramanyam, Raju Mohan, Gary Phillips, Morrissey Michael M, Mark E. Sullivan, William J. Guilford, Brad O. Buckman, Shung C. Wu, Kochanny Monica
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:657-666
A novel series of triaryloxypyridines have been designed to inhibit factor Xa, a serine protease strategically located in the coagulation cascade. Inhibitor 5e has a K I against factor Xa of 0.12 nM and is greater than 8000- and 2000-fold selective o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61b28124500c42b131140d9bea08868f
https://doi.org/10.1016/s0968-0896(01)00338-8
https://doi.org/10.1016/s0968-0896(01)00338-8
Autor:
Joseph Post, Elena Ho, Amy Liang, Ron Vergona, Raju Mohan, Lan Trinh, Marc Whitlow, Janette Walters, Morrissey Michael M, Wei Xu, Josephine Hinchman, Sunil K. Koovakkat, David D. Davey, Gary Phillips, David R. Light, Brad O. Buckman, William J. Guilford, David J. Smith, Kathy White, Mark E. Sullivan, Keith Eagen, Shung Wu, Ng Howard P, Babu Subramanyam, Kenneth J. Shaw
Publikováno v:
Journal of Medicinal Chemistry. 41:3557-3562
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27239681e30eb87c628051c339a2324
https://doi.org/10.1021/jm980280h
https://doi.org/10.1021/jm980280h
Autor:
Yuo-Ling Chou, John Morser, Marc Adler, Wheeseong Lee, Joseph Post, David R. Light, Kochanny Monica, Karna Lyn Sacchi, Dao Lentz, Arnaiz Damian O, Marc Whitlow, Bin Ye, Amy Liang, Ron Vergona, Richard W. Fitch, Mark E. Sullivan, Sarah Cheeseman, Janice Ewing, Zuchun Zhao, Babu Subramanyam, Kathy White, Kenneth J. Shaw, Karanjawala Rushad E, Janette Walters, Brian D. Griedel, Yi-Xin Wang, William P. Dole, Michael M. Morrissey, Steven T. Sakata, Galina Rumennik, Shung C. Wu
Publikováno v:
Journal of medicinal chemistry. 50(13)
There remains a high unmet medical need for a safe oral therapy for thrombotic disorders. The serine protease factor Xa (fXa), with its central role in the coagulation cascade, is among the more promising targets for anticoagulant therapy and has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9b314570fda62e22e2ae9d385e5ac9
https://pubmed.ncbi.nlm.nih.gov/17536795
https://pubmed.ncbi.nlm.nih.gov/17536795
Autor:
Arnaiz Damian O, Judi Bryant, Richard I. Feldman, Mark A. Polokoff, Gary Phillips, Paul Hrvatin, Marc Adler, James M. Wu, Babu Subramanyam, Dao Lentz, Imadul Islam, Marc Whitlow, Daguang Zhu, Kochanny Monica, Jun Shen, Janette Walters, Shendong Yuan, Elena Ho, Greg Brown
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(14)
Based on the lead compound BX-517, a series of C-4' substituted indolinones have been synthesized and evaluated for PDK1 inhibition. Modification at C-4' of the pyrrole afforded potent compounds (7b and 7d) with improved solubility and ADME propertie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ccd70016040387d3840477d0ee0a34
https://pubmed.ncbi.nlm.nih.gov/17544272
https://pubmed.ncbi.nlm.nih.gov/17544272
Autor:
Howard P, Ng, Brad O, Buckman, Keith A, Eagen, William J, Guilford, Monica J, Kochanny, Raju, Mohan, Kenneth J, Shaw, Shung C, Wu, Dao, Lentz, Amy, Liang, Lan, Trinh, Elena, Ho, David, Smith, Babu, Subramanyam, Ron, Vergona, Janette, Walters, Kathy A, White, Mark E, Sullivan, Michael M, Morrissey, Gary B, Phillips
Publikováno v:
Bioorganicmedicinal chemistry. 10(3)
A novel series of triaryloxypyridines have been designed to inhibit factor Xa, a serine protease strategically located in the coagulation cascade. Inhibitor 5e has a K(I) against factor Xa of 0.12nM and is greater than 8000- and 2000-fold selective o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1bd13ce372a62c76678fbca6b4b17c2f
https://pubmed.ncbi.nlm.nih.gov/11814853
https://pubmed.ncbi.nlm.nih.gov/11814853