Zobrazeno 1 - 10 of 57 pro vyhledávání: '"Janetta G. Culvenor"'
1
Akademický článek
Accumulation of Insoluble α-Synuclein in Dementia with Lewy Bodies
Autor: Bruce C.V. Campbell, Qiao-Xin Li, Janetta G. Culvenor, Pekka Jäkälä, Roberto Cappai, Konrad Beyreuther, Colin L. Masters, Catriona A. McLean
Publikováno v: Neurobiology of Disease, Vol 7, Iss 3, Pp 192-200 (2000)
The α-synuclein (αSN) protein is thought to play a central role in the pathogenesis of neurodegenerative diseases where it aggregates to form intracellular inclusions. We have used Western blotting to examine the expression levels and solubility of
Externí odkaz: https://doaj.org/article/6a04dd8432b5451c85bf89c8fb1dc7bb
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2
Akademický článek
Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate
Autor: Michael Ho, David E. Hoke, Yee Jia Chua, Qiao-Xin Li, Janetta G. Culvenor, Colin Masters, Anthony R. White, Geneviève Evin
Publikováno v: International Journal of Alzheimer's Disease, Vol 2011 (2011)
Gamma-secretase is involved in the production of Aβ amyloid peptides. It cleaves the transmembrane domain of the amyloid precursor protein (APP) at alternative sites to produce Aβ and the APP intracellular domain (AICD). Metal ions play an importan
Externí odkaz: https://doaj.org/article/b534918dd82a4c06aa72c5492eb1d0c0
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3
The Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase properties
Autor: George Cao, Daisy Sio-Seng Lio, Michael D. W. Griffin, Ryan D. Mills, Lung-Yu Liang, Janetta G. Culvenor, Heung-Chin Cheng, Vijaya Kenche, Terrence D. Mulhern, Yee-Foong Mok
Publikováno v: Journal of Neurochemistry. 147:409-428
The Parkinson's disease (PD)-causative leucine-rich repeat kinase 2 (LRRK2) belongs to the Roco family of G-proteins comprising a Ras-of-complex (Roc) domain followed by a C-terminal of Roc (COR) domain in tandem (called Roc-COR domain). Two prokaryo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4daf69c7be816b2c456cb0569c51d4
https://doi.org/10.1111/jnc.14566
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4
Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations
Autor: Ryan D. Mills, Heung-Chin Cheng, Janetta G. Culvenor, Terrence D. Mulhern
Publikováno v: Biochemical Society Transactions. 40:1086-1089
Various investigators have identified the major domain organization of LRRK2 (leucine-rich repeat kinase 2), which includes a GTPase ROC (Ras of complex proteins) domain followed by a COR (C-terminal of ROC) domain and a protein kinase domain. In add
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3029617cea1e2a33082522bb2471869
https://doi.org/10.1042/bst20120088
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7
Both the p33 and p55 Subunits of the Helicobacter pylori VacA Toxin Are Targeted to Mammalian Mitochondria
Autor: Terry Kwok, Janetta G. Culvenor, Trevor Lithgow, Richard L. Ferrero, Jung Hock Foo, Kip Gabriel
Publikováno v: Journal of Molecular Biology. 401:792-798
Helicobacter pylori infection causes peptic ulcers and gastric cancer. A major toxin secreted by H. pylori is the bipartite vacuolating cytotoxin A, VacA. The toxin is believed to enter host cells as two subunits: the p55 subunit (55 kDa) and the p33
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990d3d5a6ac1f562ea27f7d61881d3b5
https://doi.org/10.1016/j.jmb.2010.06.065
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8
α-Synuclein Transgenic Mice Reveal Compensatory Increases in Parkinson's Disease-Associated Proteins DJ-1 and Parkin and Have Enhanced α-Synuclein and PINK1 Levels After Rotenone Treatment
Autor: Scott Ayton, Sonia George, Milawaty Nurjono, Qiao-Xin Li, Janetta G. Culvenor, David Finkelstein, Colin L. Masters, Su San Mok
Publikováno v: Journal of Molecular Neuroscience. 42:243-254
Parkinson's disease (PD) is a severe neurodegenerative disorder characterised by loss of dopaminergic neurons of the substantia nigra. The pathological hallmarks are cytoplasmic inclusions termed Lewy bodies consisting primarily of aggregated alpha-s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae78bdb202fb806c22e454c10488ac09
https://doi.org/10.1007/s12031-010-9378-1
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9
Allosteric networks governing regulation and catalysis of Src-family protein tyrosine kinases: Implications for disease-associated kinases
Autor: Janetta G. Culvenor, Timothy M. Johnson, Khai-Chew Chan, Ryan D. Mills, Yuh-Ping Chong, Heung-Chin Cheng
Publikováno v: Clinical and Experimental Pharmacology and Physiology. 37:93-101
1. The Src-family protein tyrosine kinases (SFKs) are multidomain oncogenic protein tyrosine kinases. Their overactivation contributes to cancer formation and progression. Thus, synthetic inhibitors of SFKs are being developed as therapeutics for can
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7a020f44ebfa50a00a116c58e1fc66
https://doi.org/10.1111/j.1440-1681.2009.05237.x
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10
Paradoxical Condensation of Copper with Elevated β-Amyloid in Lipid Rafts under Cellular Copper Deficiency Conditions
Autor: Janetta G. Culvenor, Colin L. Masters, Irene Volitakis, Robert A. Cherny, Genevieve Evin, Ashley I. Bush, Qiao-Xin Li, Ya Hui Hung, Michael Ho, Elysia Robb
Publikováno v: Journal of Biological Chemistry. 284:21899-21907
Redox-active copper is implicated in the pathogenesis of Alzheimer disease (AD), β-amyloid peptide (Aβ) aggregation, and amyloid formation. Aβ·copper complexes have been identified in AD and catalytically oxidize cholesterol and lipid to generate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5036651167ff5f084def03691f435fa2
https://doi.org/10.1074/jbc.m109.019521
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