Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Janett Eckmann"'
Autor:
Schamim H. Eckert, Walter E. Müller, Janett Eckmann, Kristina Friedland, Stephanie Hagl, Gunter P. Eckert
Publikováno v:
Experimental neurology. 329
Background Approved drugs for Alzheimer's disease (AD) only have a symptomatic effects and do not intervene causally in the course of the disease. Olesoxime (TRO19622) has been tested in AD disease models characterized by improved amyloid precursor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575026f2632c88d58a169a90428a9ef5
https://pubmed.ncbi.nlm.nih.gov/32199815
https://pubmed.ncbi.nlm.nih.gov/32199815
Autor:
Janett Eckmann, Kristina Leuner, Schamim H. Eckert, Kathrin Renner, Walter E. Müller, Gunter P. Eckert
Publikováno v:
Journal of Alzheimer's Disease. 31:21-32
Due to their role in producing energy, as major sources of free radicals, and as critical regulators of apoptosis, mitochondria play a dominant role in the central nervous system (CNS). Mitochondrial dysfunction represents one major pathomechanism of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69b244136a6df43b407e7d41a696cbd
https://doi.org/10.3233/jad-2012-120310
https://doi.org/10.3233/jad-2012-120310
Autor:
Gunter P. Eckert, Kathrin Renner, Schamim H. Eckert, Walter E. Müller, Stephanie Hagl, Janett Eckmann, Kristina Leuner, Christopher Kurz, Reham M. Abdel-Kader
Publikováno v:
Molecular Neurobiology. 46:136-150
Increasing evidences suggest that mitochondrial dysfunction plays an important role in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). Alterations of mitochondrial efficiency and function are mainly related to alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f529beac70129f8d346d04ca92d84f52
https://doi.org/10.1007/s12035-012-8271-z
https://doi.org/10.1007/s12035-012-8271-z
Autor:
Stephanie Hagl, LE Clemens, Walter E. Müller, Janett Eckmann, Rebecca M. Pruss, Kristina Leuner, Gunter P. Eckert, Huu P. Nguyen, Thierry Bordet, Schamim H. Eckert, Libo Yu-Taeger
Publikováno v:
Molecular neurobiology. 50(1)
Huntington disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in exon 1 of the huntingtin gene (HTT). One prominent target of the mutant huntingtin protein (mhtt) is the mitochondrion, affecting its morphology, distri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14795986680eb2bc8d159a8f3109223d
https://pubmed.ncbi.nlm.nih.gov/24633813
https://pubmed.ncbi.nlm.nih.gov/24633813
Publikováno v:
The international journal of biochemistrycell biology. 45(1)
Mitochondria are membrane bound organelles that provide cellular energy in form of ATP. In addition to ATP synthesis mitochondria are key regulators of calcium homeostasis, free radical production, steroid synthesis and apoptosis, each of these facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc38108457c91207d4e5784acdfc87c4
https://pubmed.ncbi.nlm.nih.gov/22743330
https://pubmed.ncbi.nlm.nih.gov/22743330
Autor:
Olaf Riess, M Michaud, Bernd J. Pichler, LE Clemens, R Pruss, Jonasz J. Weber, Schamim H. Eckert, Janett Eckmann, Carsten Calaminus, Libo Yu-Taeger, TT Wlodkowski, Andreas Weiss, H Phuc Nguyen, Nicolas Casadei, Jcd Magg, Thierry Bordet, Gunter P. Eckert
Publikováno v:
Journal of neurology, neurosurgery, and psychiatry 85(Suppl 1), A96-A96 (2014). doi:10.1136/jnnp-2014-309032.278
Background Proteolytic cleavage of the mutant huntingtin protein (mHtt) leads to toxic N-terminal mHtt fragments, which are known to disrupt mitochondrial function. Olesoxime, a small cholesterol-like molecule, targets mitochondria and has demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f86f00ca5171a184e4a4df18b5150b
https://doi.org/10.1136/jnnp-2014-309032.278
https://doi.org/10.1136/jnnp-2014-309032.278
Autor:
E Portal, M Michaud, Olaf Riess, Schamim H. Eckert, Janett Eckmann, L Yu, LE Clemens, Huu P. Nguyen, Thierry Bordet, TT Wlodkowski, Gunter P. Eckert, R Pruss
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 83:A53.3-A54
Background Olesoxime, a cholesterol-oxime, is a neuroprotective compound initially developed for the treatment of ALS (Bordet et al 2007). It interacts with proteins on the outer membrane of mitochondria (OMM) and inhibits the opening of the mitochon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5cc021ac5dea88c1fc4817214569373
https://doi.org/10.1136/jnnp-2012-303524.168
https://doi.org/10.1136/jnnp-2012-303524.168
Autor:
Gunter P. Eckert, Steffi Chang, Walter E. Müller, Uwe Hener, Donat Kögel, Ekaterini Copanaki, Janett Eckmann, Stephanie Hagl
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (1):236-243
The fluidity of neuronal membranes plays a pivotal role in brain aging and neurodegeneration. In this study, we investigated the role of the omega-3 fatty acid docosahexaenoic acid (DHA) in modulation of membrane fluidity, APP processing, and protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ecdb3a879c8d6db35e08cd473b48643