Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Janete Cunha-Santos"'
Autor:
Magda M. Santana, Susana Paixão, Janete Cunha-Santos, Teresa Pereira Silva, Allyson Trevino-Garcia, Laetitia S. Gaspar, Clévio Nóbrega, Rui Jorge Nobre, Cláudia Cavadas, Hagar Greif, Luís Pereira de Almeida
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-17 (2020)
Abstract Background Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration. There is
Externí odkaz:
https://doaj.org/article/cc6e896be89b4c26ab49ef85d1e4faf9
Autor:
Helena Leal, João Cardoso, Patrícia Valério, Marta Quatorze, Vítor Carmona, Janete Cunha-Santos, Luís Pereira de Almeida, Cláudia Pereira, Cláudia Cavadas, Pedro Gomes
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6790 (2022)
Nonalcoholic fatty liver disease (NAFLD), a condition strongly associated with obesity and insulin resistance, is characterized by hepatic lipid accumulation and activation of the endoplasmic reticulum (ER) stress response. The sirtuin 2 (SIRT2) prot
Externí odkaz:
https://doaj.org/article/ff12a3b980a54a80aedc36c1dba46ad9
Autor:
Janete Cunha-Santos, Joana Duarte-Neves, Vitor Carmona, Leonard Guarente, Luís Pereira de Almeida, Cláudia Cavadas
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
SIRTs have been reported to provide neuroprotective actions in polyglutamine diseases, and are linked to the beneficial effects of caloric restrictive diets. Here, the authors show caloric restriction improves behavioural and neuropathological defici
Externí odkaz:
https://doaj.org/article/a4a2d4276c134fcebdf4609415741326
Autor:
Janete Cunha-Santos, Magda M. Santana, Luís Pereira de Almeida, Rui Jorge Nobre, Allyson Trevino-Garcia, Susana Paixão, Hagar Greif, Laetitia S. Gaspar, Clévio Nóbrega, Cláudia Cavadas, Teresa Silva
Publikováno v:
Journal of Translational Medicine
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-17 (2020)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-17 (2020)
Background Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration. There is no treatm
Autor:
Sónia Duarte, Catarina Oliveira Miranda, Luís Pereira de Almeida, Beatriz Estremores, Albert R. La Spada, Janete Cunha-Santos, João Barata
Publikováno v:
Frontiers in Cellular Neuroscience. 13
Autor:
Clévio, Nóbrega, Ana Teresa, Simões, Joana, Duarte-Neves, Sónia, Duarte, Ana, Vasconcelos-Ferreira, Janete, Cunha-Santos, Dina, Pereira, Magda, Santana, Cláudia, Cavadas, Luís Pereira, de Almeida
Publikováno v:
Advances in experimental medicine and biology. 1049
Machado-Joseph disease (MJD) is a dominantly inherited disorder originally described in people of Portuguese descent, and associated with the expansion of a CAG tract in the coding region of the causative gene MJD1/ATX3. The CAG repeats range from 10
Autor:
Joana Duarte-Neves, Dina Pereira, Janete Cunha-Santos, Sónia Duarte, Luís Pereira de Almeida, Ana Vasconcelos-Ferreira, Cláudia Cavadas, Clévio Nóbrega, Ana Simões, Magda M. Santana
Publikováno v:
Polyglutamine Disorders ISBN: 9783319717784
Machado-Joseph disease (MJD) is a dominantly inherited disorder originally described in people of Portuguese descent, and associated with the expansion of a CAG tract in the coding region of the causative gene MJD1/ATX3. The CAG repeats range from 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5d653f67d37cee7a0d1ec985929bb52
https://doi.org/10.1007/978-3-319-71779-1_18
https://doi.org/10.1007/978-3-319-71779-1_18
Autor:
Helena Leal, Lígia Sousa-Ferreira, Ana Patrícia Marques, Luís Pereira de Almeida, Janete Cunha-Santos, Joana Rosmaninho-Salgado, Cláudia Cavadas
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Background During the development of obesity the expansion of white adipose tissue (WAT) leads to a dysregulation and an excessive remodeling of extracellular matrix (ECM), leading to fibrosis formation. These ECM changes have high impact on WAT phys
Autor:
Janete Cunha-Santos, Isabel Onofre, Beverly L. Davidson, Udaya Geetha Vijayakumar, Luís Pereira de Almeida, Ana Simões, Vitor Carmona
Publikováno v:
Molecular therapy
Machado-Joseph disease (MJD) is a genetic neurodegenerative disease caused by an expanded polyglutamine tract within the protein ataxin-3 (ATXN3). Despite current efforts, MJD's mechanism of pathogenesis remains unclear and no disease-modifying treat
Autor:
Vitor Carmona, Janete Cunha-Santos, Luís Pereira de Almeida, Cláudia Cavadas, Joana Duarte-Neves, Leonard Guarente
Publikováno v:
Nature
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Machado–Joseph disease (MJD) is a neurodegenerative disorder characterized by an abnormal expansion of the CAG triplet in the ATXN3 gene, translating into a polyglutamine tract within the ataxin-3 protein. The available treatments only ameliorate s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c92a548dbca060b3f26436aa1e9a2c
https://orcid.org/0000-0003-4064-2510
https://orcid.org/0000-0003-4064-2510