Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Janet van Eersel"'
Autor:
Julia van der Hoven, Annika van Hummel, Magdalena Przybyla, Prita R. Asih, Mehul Gajwani, Astrid F. Feiten, Yazi D. Ke, Arne Ittner, Janet van Eersel, Lars M. Ittner
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract Antibodies have been explored extensively as a potential therapeutic for Alzheimer’s disease, where amyloid-β (Aβ) peptides and the tau protein deposit in patient brains. While the major focus of antibody-based therapy development was on
Externí odkaz:
https://doaj.org/article/7542fd4f0b3143c8a94362ae7f8f1328
Autor:
Daryl Ariawan, Carol Au, Esmeralda Paric, Thomas Fath, Yazi D. Ke, Michael Kassiou, Janet van Eersel, Lars M. Ittner
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The LIM-domain kinase (LIMK) family consists of two isoforms, LIMK1 and LIMK2, which are highly homologous, making selective inhibitor development challenging. LIMK regulates dynamics of the actin cytoskeleton, thereby impacting many cellular functio
Externí odkaz:
https://doaj.org/article/6f64097e86454ff89c0370f47fad2bdb
Autor:
Mian Bi, Amadeus Gladbach, Janet van Eersel, Arne Ittner, Magdalena Przybyla, Annika van Hummel, Sook Wern Chua, Julia van der Hoven, Wei S. Lee, Julius Müller, Jasneet Parmar, Georg von Jonquieres, Holly Stefen, Ernesto Guccione, Thomas Fath, Gary D. Housley, Matthias Klugmann, Yazi D. Ke, Lars M. Ittner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Excitotoxicity contributes to neuronal injury following stroke. Here the authors show that tau promotes excitotoxicity by a post-synaptic mechanism, involving site-specific control of ERK activation, in a mouse model of stroke.
Externí odkaz:
https://doaj.org/article/97fd15d6e4f1429dae0533cf6a3311e1
Autor:
Yazi D. Ke, Alexandra K. Suchowerska, Julia van der Hoven, Dineeka M. De Silva, Christopher W. Wu, Janet van Eersel, Arne Ittner, Lars M. Ittner
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2012 (2012)
Both Alzheimer's disease (AD) and frontotemporal dementia (FTD) are characterized by the deposition of hyperphosphorylated forms of the microtubule-associated protein tau in neurons and/or glia. This unifying pathology led to the umbrella term “tau
Externí odkaz:
https://doaj.org/article/131c18a42780400fbfb899c8c25dda5e
Autor:
Janet van Eersel, Yazi D Ke, Amadeus Gladbach, Mian Bi, Jürgen Götz, Jillian J Kril, Lars M Ittner
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22850 (2011)
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are characterized by intraneuronal deposition of the nuclear TAR DNA-binding protein 43 (TDP-43) caused by unknown mechanisms. Here, we studied TDP-43 in primary neurons
Externí odkaz:
https://doaj.org/article/69f49bd98aa64fb0a3674d388e05e148
Autor:
Nicolle Morey, Magdalena Przybyla, Julia van der Hoven, Yazi D. Ke, Fabien Delerue, Janet van Eersel, Lars M. Ittner
Publikováno v:
Science advances. 8(48)
Hyperphosphorylated microtubule-associated protein tau has been implicated in dementia, epilepsy, and other neurological disorders. In contrast, site-specific phosphorylation of tau at threonine 205 (T205) by the kinase p38γ was shown to disengage t
Publikováno v:
Biomaterials science. 10(15)
Vaccination is a proven way to protect individuals against many infectious diseases, as currently highlighted in the global COVID-19 pandemic. Peptides- or small molecule antigen-based vaccination offer advantages over the classical vaccine approache
Autor:
Tim Karl, Valeria Zak, Georgia Watt, Lars M. Ittner, Janet van Eersel, Magdalena Przybyla, Arne Ittner
Publikováno v:
Neuroscience. 431:166-175
Alzheimer’s disease (AD) is a neurodegenerative disease characterised by progressive cognitive decline and the accumulation of two hallmark proteins, amyloid-beta (Aβ) and tau. Traditionally, transgenic mouse models for AD have generally focused o
Autor:
Julius Muller, Magdalena Przybyla, Holly Stefen, Amadeus Gladbach, Ernesto Guccione, Gary D. Housley, Thomas Fath, Wei S. Lee, Lars M. Ittner, Annika van Hummel, Jasneet Parmar, Julia van der Hoven, Mian Bi, Arne Ittner, Matthias Klugmann, Yazi D. Ke, Janet van Eersel, Sook Wern Chua, Georg von Jonquieres
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications
Neuronal excitotoxicity induced by aberrant excitation of glutamatergic receptors contributes to brain damage in stroke. Here we show that tau-deficient (tau−/−) mice are profoundly protected from excitotoxic brain damage and neurological deficit
Autor:
Thomas Mueller, Anne E. Harasta, Yazi D. Ke, Claire H. Stevens, Julius Muller, Emmanuel Prikas, Tim Karl, Annika van Hummel, Gary D. Housley, Mehul Gajwani, Magdalena Przybyla, Miheer Sabale, Arne Ittner, John M. Power, Julia van der Hoven, Janet van Eersel, Lars M. Ittner, Michael Kassiou
Publikováno v:
Brain : a journal of neurology. 143(6)
Hyperphosphorylation and deposition of tau in the brain characterizes frontotemporal dementia and Alzheimer’s disease. Disease-associated mutations in the tau-encoding MAPT gene have enabled the generation of transgenic mouse models that recapitula