Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Janet Y. Leung"'
Autor:
Yao Jiang, Yanqiong Zhang, Janet Y. Leung, Cheng Fan, Konstantin I. Popov, Siyuan Su, Jiayi Qian, Xiaodong Wang, Alisha Holtzhausen, Eric Ubil, Yang Xiang, Ian Davis, Nikolay V. Dokholyan, Gang Wu, Charles M. Perou, William Y. Kim, H. Shelton Earp, Pengda Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Hyperactivation of Akt promotes tumorigenesis. Here, the authors show that SAV1, a member of Hippo signalling, interacts with Akt to suppress Akt activity and MERTK-mediated Akt phosphorylation relieves this suppression to facilitate Akt oncogenic ac
Externí odkaz:
https://doaj.org/article/b6df3eea370a40a0932a4398891238b5
Autor:
Sean T. Bailey, Aleisha M. Smith, Jordan Kardos, Sara E. Wobker, Harper L. Wilson, Bhavani Krishnan, Ryoichi Saito, Hyo Jin Lee, Jing Zhang, Samuel C. Eaton, Lindsay A. Williams, Ujjawal Manocha, Dorien J. Peters, Xinchao Pan, Thomas J. Carroll, Dean W. Felsher, Vonn Walter, Qing Zhang, Joel S. Parker, Jen Jen Yeh, Richard A. Moffitt, Janet Y. Leung, William Y. Kim
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Renal cell carcinoma (RCC) is a common and aggressive malignancy. Here, the authors generate two mouse models of the most common RCC subtypes: the human papillary RCC throughMYC activation and clear cell RCC through MYC activation combined with Vhl a
Externí odkaz:
https://doaj.org/article/0f0c33aaa830403a92bded52b464aea5
Autor:
William Y. Kim, Ian J. Davis, Jeremy M. Simon, Austin J. Hepperla, Kathryn H. Gessner, Janet Y. Leung, Mi Zhou
Supplementary Data from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acd9ac6ece0b1dcbf7b586a7187e348
https://doi.org/10.1158/2326-6066.22544229
https://doi.org/10.1158/2326-6066.22544229
Autor:
William Y. Kim, Ian J. Davis, Jeremy M. Simon, Austin J. Hepperla, Kathryn H. Gessner, Janet Y. Leung, Mi Zhou
Clear cell renal cell carcinoma (ccRCC) is considered an immunotherapy-responsive disease; however, the reasons for this remain unclear. Studies have variably implicated PBRM1 mutations as a predictive biomarker of immune checkpoint blockade (ICB) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00964cde4fd0f94aabbdc277c4898b46
https://doi.org/10.1158/2326-6066.c.6550584.v1
https://doi.org/10.1158/2326-6066.c.6550584.v1
Autor:
William Y. Kim, Ian J. Davis, Jeremy M. Simon, Austin J. Hepperla, Kathryn H. Gessner, Janet Y. Leung, Mi Zhou
Supplementary Figure from PBRM1 Inactivation Promotes Upregulation of Human Endogenous Retroviruses in a HIF-Dependent Manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400cb2c8c6033f1649c0301e24d3ac3b
https://doi.org/10.1158/2326-6066.22544226
https://doi.org/10.1158/2326-6066.22544226
Autor:
William Y. Kim, Janet Y. Leung
There is a need for the discovery of novel therapeutic strategies to effectively treat advanced clear cell renal cell carcinoma (ccRCC). Inhibition of stearoyl-coA desaturase 1 (SCD1) in ccRCC reveals antitumor activity, independently and in synergy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b674b8622df4586e3bd4a64c13d729
https://doi.org/10.1158/1078-0432.c.6521034.v1
https://doi.org/10.1158/1078-0432.c.6521034.v1
Autor:
William Y. Kim, Janet Y. Leung
Supplementary Data from Stearoyl Co-A Desaturase 1 as a ccRCC Therapeutic Target: Death by Stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0daaeaa75c3e388b9ee8bbb61f428eb7
https://doi.org/10.1158/1078-0432.22447308
https://doi.org/10.1158/1078-0432.22447308
Autor:
Phillip G. Febbo, Massimo Loda, William C. Hahn, Beth A. Sullivan, Janet Y. Leung, Adam Foye, Wayne Glover, David S. Hsu, Alessandro Porrello, Bala S. Balakumaran
Supplementary Tables 1-2, Figure Legends 1-4 from MYC Activity Mitigates Response to Rapamycin in Prostate Cancer through Eukaryotic Initiation Factor 4E–Binding Protein 1–Mediated Inhibition of Autophagy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f083819550ae212bc9bd21219558e8
https://doi.org/10.1158/0008-5472.22377992
https://doi.org/10.1158/0008-5472.22377992
Autor:
Phillip G. Febbo, Massimo Loda, William C. Hahn, Beth A. Sullivan, Janet Y. Leung, Adam Foye, Wayne Glover, David S. Hsu, Alessandro Porrello, Bala S. Balakumaran
Supplementary Figure 1 from MYC Activity Mitigates Response to Rapamycin in Prostate Cancer through Eukaryotic Initiation Factor 4E–Binding Protein 1–Mediated Inhibition of Autophagy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4036bd5a84a8a3ff84c71663b472c4
https://doi.org/10.1158/0008-5472.22378004.v1
https://doi.org/10.1158/0008-5472.22378004.v1
Autor:
Phillip G. Febbo, Massimo Loda, William C. Hahn, Beth A. Sullivan, Janet Y. Leung, Adam Foye, Wayne Glover, David S. Hsu, Alessandro Porrello, Bala S. Balakumaran
Supplementary Figure 3 from MYC Activity Mitigates Response to Rapamycin in Prostate Cancer through Eukaryotic Initiation Factor 4E–Binding Protein 1–Mediated Inhibition of Autophagy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fabc49d2be7b117c2e0361d96d90fd6
https://doi.org/10.1158/0008-5472.22377998.v1
https://doi.org/10.1158/0008-5472.22377998.v1