Výsledky vyhledávání - "Janet W. Maynard"

FDA orphan products clinical trial grants: assessment of outcomes and impact on rare disease product development

Autor: Katherine I. Miller Needleman, Gumei Liu, Kathleen L. Miller, Janet W. Maynard, Christine M. Mueller

Publikováno v: Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-8 (2020)
Orphanet Journal of Rare Diseases

Background The Office of Orphan Products Development (OOPD) of the United States (U.S.) Food and Drug Administration (FDA) has awarded over 700 grants to conduct clinical trials of medicals products for rare diseases since 1983, leading to over 70 ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84167a06d4837d7e47364e5b69d5b981
http://link.springer.com/article/10.1186/s13023-020-01514-5

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Using four decades of FDA orphan drug designations to describe trends in rare disease drug development: substantial growth seen in development of drugs for rare oncologic, neurologic, and pediatric-onset diseases

Autor: Janet W. Maynard, Kathleen L. Miller, Lewis J. Fermaglich

Publikováno v: Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-10 (2021)
Orphanet Journal of Rare Diseases

Background Orphan drug designations are a useful proxy to investigate trends in rare disease drug development. Drug developers must receive a designation before they are eligible for the economic incentives of the Orphan Drug Act in the United States

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514f4e09c141754c69f19bff6618dd67
https://doi.org/10.1186/s13023-021-01901-6

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Hypertension and the Risk of Incident Gout in a Population-Based Study: The Atherosclerosis Risk in Communities Cohort

Autor: Janet W. Maynard, Mara McAdams-DeMarco, Alan N. Baer, Josef Coresh

Publikováno v: The Journal of Clinical Hypertension. 14:675-679

The authors quantified the impact of hypertension on gout incidence in middle-aged white and African American men and women. The Atherosclerosis Risk in Communities Study (ARIC) was a prospective population-based cohort that recruited patients betwee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42b86e4faf63e83b696c16b2a1450818
https://doi.org/10.1111/j.1751-7176.2012.00674.x

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Diuretic use, increased serum urate levels, and risk of incident gout in a population-based study of adults with hypertension: The Atherosclerosis Risk in Communities cohort study

Autor: Allan C. Gelber, J. Hunter Young, Janet W. Maynard, Alvaro Alonso, Mara A. McAdams DeMarco, Alan N. Baer, Josef Coresh

Publikováno v: Arthritis & Rheumatism. 64:121-129

To quantify the role of diuretic use in gout development in an adult population with hypertension.The Atherosclerosis Risk in Communities study, a prospective population-based cohort from 4 US communities, consisted of 4 visits over a 9-year period.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283d957ac06ac938815b290599944d80
https://doi.org/10.1002/art.33315

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Obesity and younger age at gout onset in a community-based cohort

Autor: Janet W. Maynard, Mara McAdams DeMarco, Allan C. Gelber, Anna Köttgen, Mary Margret Huizinga, Josef Coresh, Alan N. Baer

Publikováno v: Arthritis Care & Research. 63:1108-1114

In the US, the incidence and prevalence of both obesity and gout is rising (1–3). Obesity has been associated with an increased risk of gout (4–7). However, two of the studies that identified this gout risk factor were conducted among male health

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31e94dc05c2f612b768804dcf8191d68
https://doi.org/10.1002/acr.20479

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Testicular Pain Followed by Microscopic Hematuria, a Renal Mass, Palpable Purpura, Polyarthritis, and Hematochezia

Autor: Lisa Christopher-Stine, Janet W. Maynard, Allan C. Gelber

Publikováno v: JCR: Journal of Clinical Rheumatology. 16:388-391

We present the instructive case of a man who developed progressively severe testicular pain. He sought the medical care of several physicians, including general medicine, urology, and rheumatology. What began with focal testicular pain evolved over t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8131f4a3efba169c43c12d37066f101e
https://doi.org/10.1097/rhu.0b013e3181fe8bbe

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Reliability and Sensitivity of the Self-report of Physician-diagnosed Gout in the Campaign Against Cancer and Heart Disease and the Atherosclerosis Risk in the Community Cohorts

Autor: Sandra Clipp, Mara A. McAdams, Janet W. Maynard, Anna Köttgen, Alan N. Baer, Allan C. Gelber, Josef Coresh

Publikováno v: The Journal of Rheumatology. 38:135-141

Objective.Gout is often defined by self-report in epidemiologic studies. Yet the validity of self-reported gout is uncertain. We evaluated the reliability and sensitivity of the self-report of physician-diagnosed gout in the Campaign Against Cancer a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8432af6876fe8ec9f5b2a8dd1f47f6f
https://doi.org/10.3899/jrheum.100418

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Vitamin D Treatment for the Prevention of Falls in Older Adults: Systematic Review and Meta-Analysis

Autor: Ritu Valiyil, Brady L. Stein, Janet W. Maynard, Deidra C. Crews, Rita R. Kalyani, Rebecca Manno

Publikováno v: Journal of the American Geriatrics Society. 58:1299-1310

OBJECTIVES: To systematically review and quantitatively synthesize the effect of vitamin D therapy on fall prevention in older adults. DESIGN: Systematic review and meta-analysis. SETTING: MEDLINE, CINAHL, Web of Science, EMBASE, Cochrane Library, LI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a08f6fa59542c704f7b12b6ce1852ca9
https://doi.org/10.1111/j.1532-5415.2010.02949.x

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