Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Janet Sredy"'
Autor:
Alberto Podjarny, Andre Mitschler, Kerry Combs, Evelyn O. Sibley, Al Sabetta, Erin E. McCann, Anne L. Carrington, Eduardo Howard, Diane R. Sawicki, Janet Sredy, Brenda R. Flam, Michael C. Van Zandt
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:5661-5675
Recent efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid aldose reductase inhibitors. The compound class features a
Autor:
Janet Sredy, Brenda Mihan, Iwan Gunawan, Michael S. Malamas, Donald Sullivan, Michael McCaleb
Publikováno v:
European Journal of Medicinal Chemistry. 36:31-42
A series of 1,2,4-oxadiazolidine-3,5-diones was synthesized and evaluated as oral antihyperglycemic agents in the obese insulin resistant db/db and ob/ob mouse — the two models for Type 2 diabetes mellitus. The majority of the prepared methoxy- and
Publikováno v:
Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, 2009, 19 (7), pp.2006-8. ⟨10.1016/j.bmcl.2009.02.037⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2009, 19 (7), pp.2006-8. ⟨10.1016/j.bmcl.2009.02.037⟩
Bioorganic and Medicinal Chemistry Letters, 2009, 19 (7), pp.2006-8. ⟨10.1016/j.bmcl.2009.02.037⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2009, 19 (7), pp.2006-8. ⟨10.1016/j.bmcl.2009.02.037⟩
International audience; Efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic a
Autor:
Michael L. McCaleb, Jay Wrobel, Zenan Li, Janet Sredy, Brenda Mihan, Donald Sullivan, Arlene Joan Dietrich
Publikováno v:
Journal of Medicinal Chemistry. 41:1084-1091
Novel 5-(3-aryl-2-propynyl)-5-(arylsulfonyl)thiazolidine-2,4-diones and 5-(3-aryl-2-propynyl)-5-(arylsulfanyl)thiazolidine-2,4-diones were prepared and evaluated as oral antihyperglycemic agents in the obese, insulin resistant db/db mouse model at 10
Publikováno v:
Experimental Eye Research. 65:223-229
Small heat shock proteins and alpha-crystallins are related proteins with several common structural and functional properties including homologous amino acid sequences and similar chaperone-like activity. Furthermore, small heat shock proteins and al
Publikováno v:
Metabolism. 44:1074-1081
Insulin resistance in the ob/ob mouse model is associated with a reduction in insulin-induced protein-tyrosine phosphorylation in tissues such as liver. To ascertain whether this decrease in phosphorylation may be due to increased phosphatase activit
Autor:
Jay Wrobel, Janet Sredy
Publikováno v:
Expert Opinion on Investigational Drugs. 3:1277-1280
Today's need for effective oral glucose lowering agents and the recent advances in the understanding of the molecular mechanisms of insulin action have increased attention to the use of vanadate as an oral euglycaemic agent. Vanadate has metabolic ac
Autor:
Janet Sredy, Jay Wrobel, Arlene Joan Dietrich, Michael L. McCaleb, Zenan Li, Brenda Mihan, Donald Sullivan
Publikováno v:
ChemInform. 29
Novel 5-(3-aryl-2-propynyl)-5-(arylsulfonyl)thiazolidine-2,4-diones and 5-(3-aryl-2-propynyl)-5-(arylsulfanyl)thiazolidine-2,4-diones were prepared and evaluated as oral antihyperglycemic agents in the obese, insulin resistant db/db mouse model at 10
Autor:
Iwan Gunawan, Diane R. Sawicki, Brenda R. Flam, Laura Seestaller, Brenda Mihan, Donald Sullivan, Michael S. Malamas, Janet Sredy
Publikováno v:
ChemInform. 31
Insulin resistance in the liver and peripheral tissues together with a pancreatic cell defect are the common causes of type 2 diabetes. It is now appreciated that insulin resistance can result from a defect in the insulin receptor signaling system, a
Autor:
Iwan Gunawan, Brenda Mihan, Donald Sullivan, Michael L. McCaleb, Michael S. Malamas, Janet Sredy
Publikováno v:
ChemInform. 32