Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Janet S. May"'
Publikováno v:
PLoS Pathogens, Vol 12, Iss 5, p e1005654 (2016)
Gamma-herpesviruses colonise lymphocytes. Murid Herpesvirus-4 (MuHV-4) infects B cells via epithelial to myeloid to lymphoid transfer. This indirect route entails exposure to host defences, and type I interferons (IFN-I) limit infection while viral e
Externí odkaz:
https://doaj.org/article/4788dd042f36420b8422faafff01117e
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004761 (2015)
Rhadinoviruses establish chronic infections of clinical and economic importance. Several show respiratory transmission and cause lung pathologies. We used Murid Herpesvirus-4 (MuHV-4) to understand how rhadinovirus lung infection might work. A primar
Externí odkaz:
https://doaj.org/article/1eca3804a80c477cb6ada38655532043
Publikováno v:
PLoS Pathogens, Vol 8, Iss 9, p e1002935 (2012)
Gamma-herpesviruses persist in lymphocytes and cause disease by driving their proliferation. Lymphocyte infection is therefore a key pathogenetic event. Murid Herpesvirus-4 (MuHV-4) is a rhadinovirus that like the related Kaposi's Sarcoma-associated
Externí odkaz:
https://doaj.org/article/78884973648844a49b0d65b544b96ed1
Autor:
Miguel Gaspar, Janet S May, Soumi Sukla, Bruno Frederico, Michael B Gill, Christopher M Smith, Gabrielle T Belz, Philip G Stevenson
Publikováno v:
PLoS Pathogens, Vol 7, Iss 11, p e1002346 (2011)
Dendritic cells (DCs) play a central role in initiating immune responses. Some persistent viruses infect DCs and can disrupt their functions in vitro. However, these viruses remain strongly immunogenic in vivo. Thus what role DC infection plays in th
Externí odkaz:
https://doaj.org/article/830c8ca746b345b0b9ab1eb3ea162939
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11080 (2010)
The narrow species tropisms of Epstein-Barr Virus (EBV) and the Kaposi's Sarcoma -associated Herpesvirus (KSHV) have made Murid Herpesvirus-4 (MuHV-4) an important tool for understanding how gammaherpesviruses colonize their hosts. However, while MuH
Externí odkaz:
https://doaj.org/article/8fd7eb01070a434cbd5e0823392de993
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2781 (2008)
All gamma-herpesviruses encode at least one homolog of the cellular enzyme formyl-glycineamide-phosphoribosyl-amidotransferase. Murid herpesvirus-4 (MuHV-4) encodes 3 (ORFs 75a, 75b and 75c), suggesting that at least some copies have acquired new fun
Externí odkaz:
https://doaj.org/article/8d7407b7b40947dc823855860ac299fe
Publikováno v:
PLoS ONE, Vol 3, Iss 5, p e2131 (2008)
Murid herpesvirus-4 (MuHV-4) provides a tractable model with which to define common, conserved features of gamma-herpesvirus biology. The multi-membrane spanning glycoprotein M (gM) is one of only 4 glycoproteins that are essential for MuHV-4 lytic r
Externí odkaz:
https://doaj.org/article/62a83e29eb27465d9093a366d30ab11b
Publikováno v:
PLoS ONE, Vol 3, Iss 3, p e1808 (2008)
Viruses lack self-propulsion. To move in multi-cellular hosts they must therefore manipulate infected cells. Herpesviruses provide an archetype for many aspects of host manipulation, but only for alpha-herpesviruses in is there much information about
Externí odkaz:
https://doaj.org/article/fcbf146ff295449cb5b27e026d274e99
Publikováno v:
PLoS ONE, Vol 2, Iss 10, p e1048 (2007)
Dendritic cells (DCs) play a central role in initiating adaptive immunity. Murine gammaherpesvirus-68 (MHV-68), like many persistent viruses, infects DCs during normal host colonization. It therefore provides a means to understanding what host and vi
Externí odkaz:
https://doaj.org/article/3f828d4766b74355a6e2ad261d4ddbc5
Publikováno v:
PLoS ONE, Vol 2, Iss 9, p e899 (2007)
Herpesvirus carriers transmit infection despite making virus-specific antibodies. Thus, their antibody responses are not necessarily optimal. An important question for infection control is whether vaccinating carriers might improve virus neutralizati
Externí odkaz:
https://doaj.org/article/fdffccd7500240e2bb92b3de7939b72e