Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Janet S, Sinsheimer"'
Autor:
Kristina M. Garske, Asha Kar, Caroline Comenho, Brunilda Balliu, David Z. Pan, Yash V. Bhagat, Gregory Rosenberg, Amogha Koka, Sankha Subhra Das, Zong Miao, Janet S. Sinsheimer, Jaakko Kaprio, Kirsi H. Pietiläinen, Päivi Pajukanta
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Obesity-induced adipose tissue dysfunction can cause low-grade inflammation and downstream obesity comorbidities. Although preadipocytes may contribute to this pro-inflammatory environment, the underlying mechanisms are unclear. We used huma
Externí odkaz:
https://doaj.org/article/3055f5bb90004824b10bd459d9c63909
Autor:
Nicholas Darci-Maher, Marcus Alvarez, Uma Thanigai Arasu, Ilakya Selvarajan, Seung Hyuk T. Lee, David Z. Pan, Zong Miao, Sankha Subhra Das, Dorota Kaminska, Tiit Örd, Jihane N. Benhammou, Martin Wabitsch, Joseph R. Pisegna, Ville Männistö, Kirsi H. Pietiläinen, Markku Laakso, Janet S. Sinsheimer, Minna U. Kaikkonen, Jussi Pihlajamäki, Päivi Pajukanta
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104620- (2023)
Summary: Background: Non-alcoholic fatty liver disease (NAFLD) is a fast-growing, underdiagnosed, epidemic. We hypothesise that obesity-related inflammation compromises adipose tissue functions, preventing efficient fat storage, and thus driving ecto
Externí odkaz:
https://doaj.org/article/d790980f12064df98a63142b4ca4e5bb
Autor:
Marcus Alvarez, Jihane N. Benhammou, Nicholas Darci-Maher, Samuel W. French, Steven B. Han, Janet S. Sinsheimer, Vatche G. Agopian, Joseph R. Pisegna, Päivi Pajukanta
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-20 (2022)
Abstract Background Hepatocellular carcinoma (HCC) is a common primary liver cancer with poor overall survival. We hypothesized that there are HCC-associated cell-types that impact patient survival. Methods We combined liver single nucleus (snRNA-seq
Externí odkaz:
https://doaj.org/article/b62ad1317f6142be85870e21adbd7bd9
Autor:
Kimberly C. Paul, Cynthia Kusters, Melissa Furlong, Keren Zhang, Yu Yu, Aline Duarte Folle, Irish Del Rosario, Adrienne Keener, Jeff Bronstein, Janet S. Sinsheimer, Steve Horvath, Beate Ritz
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 26, Iss , Pp 100530- (2022)
Although Parkinson's Disease (PD) is typically described in terms of motor symptoms, depression is a common feature. We explored whether depression influences blood-based genome-wide DNA methylation (DNAm) in 692 subjects from a population-based PD c
Externí odkaz:
https://doaj.org/article/9f4dcc61389f436b9e8fc7c739f3b732
Autor:
Yvonne N. Flores, Aryana T. Amoon, Baolong Su, Rafael Velazquez-Cruz, Paula Ramírez-Palacios, Jorge Salmerón, Berenice Rivera-Paredez, Janet S. Sinsheimer, Aldons J. Lusis, Adriana Huertas-Vazquez, Sammy Saab, Beth A. Glenn, Folasade P. May, Kevin J. Williams, Roshan Bastani, Steven J. Bensinger
Publikováno v:
Lipids in Health and Disease, Vol 20, Iss 1, Pp 1-17 (2021)
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and cirrhosis. NAFLD is mediated by changes in lipid metabolism and known risk factors include obesity, metabolic syndrome, and diabetes. The aim
Externí odkaz:
https://doaj.org/article/37bef688082e4aa795640c4fb24a17e1
Autor:
David Z. Pan, Zong Miao, Caroline Comenho, Sandhya Rajkumar, Amogha Koka, Seung Hyuk T. Lee, Marcus Alvarez, Dorota Kaminska, Arthur Ko, Janet S. Sinsheimer, Karen L. Mohlke, Nicholas Mancuso, Linda Liliana Muñoz-Hernandez, Miguel Herrera-Hernandez, Maria Teresa Tusié-Luna, Carlos Aguilar-Salinas, Kirsi H. Pietiläinen, Jussi Pihlajamäki, Markku Laakso, Kristina M. Garske, Päivi Pajukanta
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-20 (2021)
Abstract Background Obesity predisposes individuals to multiple cardiometabolic disorders, including type 2 diabetes (T2D). As body mass index (BMI) cannot reliably differentiate fat from lean mass, the metabolically detrimental abdominal obesity has
Externí odkaz:
https://doaj.org/article/a78b7b24f81c435489080bb179d2de77
Autor:
Sarah S. Ji, Christopher A. German, Kenneth Lange, Janet S. Sinsheimer, Hua Zhou, Jin Zhou, Eric M. Sobel
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Statistical geneticists employ simulation to estimate the power of proposed studies, test new analysis tools, and evaluate properties of causal models. Although there are existing trait simulators, there is ample room for moderniz
Externí odkaz:
https://doaj.org/article/3207b3d528f54481a8504f812aa9c433
Autor:
Zong Miao, Kristina M. Garske, David Z. Pan, Amogha Koka, Dorota Kaminska, Ville Männistö, Janet S. Sinsheimer, Jussi Pihlajamäki, Päivi Pajukanta
Publikováno v:
HGG Advances, Vol 3, Iss 1, Pp 100056- (2022)
Summary: The prevalence of non-alcoholic fatty liver disease (NAFLD), now also known as metabolic dysfunction-associated fatty liver disease (MAFLD), is rapidly increasing worldwide due to the ongoing obesity epidemic. However, currently the NALFD di
Externí odkaz:
https://doaj.org/article/fe9cefe5eea64463923435bf7c13eb93
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0247046 (2021)
Interacting Particle Systems (IPSs) are used to model spatio-temporal stochastic systems in many disparate areas of science. We design an algorithmic framework that reduces IPS simulation to simulation of well-mixed Chemical Reaction Networks (CRNs).
Externí odkaz:
https://doaj.org/article/c4659dffb64c4ee0a64381b28271be0c
Autor:
Alfonso Landeros, Xiang Ji, Kenneth Lange, Timothy C Stutz, Jason Xu, Mary E Sehl, Janet S Sinsheimer
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251242 (2021)
The SARS-CoV-2 pandemic led to closure of nearly all K-12 schools in the United States of America in March 2020. Although reopening K-12 schools for in-person schooling is desirable for many reasons, officials understand that risk reduction strategie
Externí odkaz:
https://doaj.org/article/7ed168186d56484293aa6f2788d26161