Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Janet S, Kerr"'
Autor:
Janet S. Kerr
Publikováno v:
Interstitial Lung Diseases in Children ISBN: 9780429268854
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f50efad25f1521787049de1635e1db94
https://doi.org/10.1201/9780429268854-10
https://doi.org/10.1201/9780429268854-10
Autor:
David N Durrheim, Julie Kohlhagen, Janet S. Kerr, Adrienne Dale, J.C. Bennett, Craig B Dalton, Devin N. Jones, Alison J. Peel, Tony Merritt, S. Wheeler, P. Freeman, Kirsten M Williamson, Kirk Silas, Peggy Eby, Tambri Housen, Liam Chirio
Publikováno v:
One Health
One Health, Vol 10, Iss, Pp 100162-(2020)
One Health, Vol 10, Iss, Pp 100162-(2020)
In June 2019 the first equine case of Hendra virus in the Hunter Valley, New South Wales, Australia was detected. An urgent human and animal health response took place, involving biosecurity measures, contact tracing, promotion of equine vaccinations
Autor:
Janet S. Kerr
Publikováno v:
CRC Handbook of Animal Models of Pulmonary Disease ISBN: 9781351070973
CRC Handbook of Animal Models of Pulmonary Disease
CRC Handbook of Animal Models of Pulmonary Disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a605815db39f7924d83a0072011b7479
https://doi.org/10.1201/9781351070973-15
https://doi.org/10.1201/9781351070973-15
Autor:
Donald Nelson, Gary G. Chicchi, James Dellureficio, Ravi P. Nargund, Peter H. Dobbelaar, Liangqin Guo, Kwei-Lan Tsao, Janet S. Kerr, Bei Zhang, Zhong Lai, Patricia R. Bunting, Shrenik K. Shah, Raman K. Bakshi, Qingmei Hong, Hongbo Qi, Guillermo Fernandez, Mikhail Reibarkh, Qing Shao, Quang Truong, Koppara Samuel, Jian Liu, Sylvia Volksdorf, Zhixiong Ye, Yun-Ping Zhou, Margaret Wu, Cai Li, Stan Mitelman, Andrew D. Howard, Wu Du, Maria E. Trujillo, George J. Eiermann, Shuwen He, Vijay Bhasker G. Reddy, Tianying Jian, Pierre Morissette, Patrick Fitzgerald, Dorina Trusca, Sharon Tong, William K. Hagmann
Publikováno v:
ACS Medicinal Chemistry Letters. 5:748-753
Antagonism of somatostatin subtype receptor 3 (sstr3) has emerged as a potential treatment of Type 2 diabetes. Unfortunately, the development of our first preclinical candidate, MK-4256, was discontinued due to a dose-dependent QTc (QT interval corre
Autor:
Victoria M. Richon, Thomas A. Miller, Janet S. Kerr, Armando Lagrutta, Michael J. Armstrong, Paul A. Andrews, Sheila M. Galloway
Publikováno v:
International Journal of Toxicology. 29:3-19
Vorinostat (SAHA, Zolinza), a histone deacetylase inhibitor, is assessed in nonclinical studies to support its approval for cutaneous T-cell lymphoma. Vorinostat is weakly mutagenic in the Ames assay; is clastogenic in rodent (ie, CHO) cells but not
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 83:19-26
BACKGROUND: Histone deacetylase (HDAC) inhibitors have been shown to mediate the regulation of gene expression, induce cell growth, cell differentiation, and apoptosis of tumor cells. These compounds are now marketed or are in clinical development. O
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 80:57-68
BACKGROUND: The developmental toxicity potential of vorinostat (suberoylanilide hydroxamic acid [SAHA], ZOLINZA™), a potent inhibitor of histone deacetylase (HDAC), was assessed in Sprague-Dawley rats and Dutch Belted rabbits. HDAC inhibitors have
Autor:
Yang Yu, Gary G. Chicchi, Frederick Wong, Janet S. Kerr, Sharon Tong, Zhe Feng, Guillermo Fernandez, Edward C. Sherer, Kwei-Lan Tsao, Qing Shao, Bei B. Zhang, Yun-Ping Zhou, Pierre Morissette, Shuwen He, Shrenik K. Shah, Vijay Bhasker G. Reddy, Liangqin Guo, Ravi P. Nargund, Margaret Wu, Cai Li, Zhixiong Ye, Alexander Pasternak, George J. Eiermann, Patricia R. Bunting, Hongbo Qi, Michele Pachanski, Stan Mitelman, Maria E. Trujillo, Quang Truong, Maria Madiera, Andrew D. Howard, Donald Nelson, Qingmei Hong, Zhong Lai, Yue Feng, Bindhu V. Karanam, Jian Liu, Koppara Samuel, Wu Du, William K. Hagmann, Tianying Jian, Dorina Trusca, Sylvia Volksdorf, Peter H. Dobbelaar
Publikováno v:
ACS medicinal chemistry letters. 6(5)
The imidazolyl-tetrahydro-β-carboline class of sstr3 antagonists have demonstrated efficacy in a murine model of glucose excursion and may have potential as a treatment for type 2 diabetes. The first candidate in this class caused unacceptable QTc i
Publikováno v:
Expert Opinion on Investigational Drugs. 11:1765-1774
Integrins are involved in many cellular processes, including some pathological ones associated with various cancers, both solid tumours and metastases. Since integrins are involved in such critical processes as gene expression, which lead to cellular
Publikováno v:
Expert Opinion on Investigational Drugs. 9:1271-1279
The members of the integrin family are targets that potentially provide both therapeutic and diagnostic opportunities. Advances in the understanding of the signalling pathways, transcriptional regulation and the structure/function relationships of th