Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Janet R Fields"'
Autor:
Yih-Horng Shiao, Robert M Leighty, Cuiju Wang, Xin Ge, Erik B Crawford, Joshua M Spurrier, Sean D McCann, Janet R Fields, Laura Fornwald, Lisa Riffle, Craig Driver, Octavio A Quiñones, Ralph E Wilson, Kazimierz S Kasprzak, Gregory S Travlos, W Gregory Alvord, Lucy M Anderson
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22266 (2011)
Gene rearrangement occurs during development in some cell types and this genome dynamics is modulated by intrinsic and extrinsic factors, including growth stimulants and nutrients. This raises a possibility that such structural change in the genome a
Externí odkaz:
https://doaj.org/article/813529c8893d4bfd9c40e7a11ec82dfb
Autor:
Yih-Horng Shiao, Sorin T Lupascu, Yuhan D Gu, Wojciech Kasprzak, Christopher J Hwang, Janet R Fields, Robert M Leighty, Octavio Quiñones, Bruce A Shapiro, W Gregory Alvord, Lucy M Anderson
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7505 (2009)
Ribosomal RNA (rRNA) is a central regulator of cell growth and may control cancer development. A cis noncoding rRNA (nc-rRNA) upstream from the 45S rRNA transcription start site has recently been implicated in control of rRNA transcription in mouse f
Externí odkaz:
https://doaj.org/article/8f2e7461c53b47b7b36b8ffa0babccbc
Publikováno v:
International Journal of Cancer. 130:251-258
The use of siRNAs against specific molecular targets has potential for cancer therapy but has been thought to be limited by the need for formulation to improve cellular uptake. Lung adenocarcinoma cells are markedly suppressed in culture by siRNAs to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8e8b7b2bf4ea2edcab92296296afd8
https://doi.org/10.1002/ijc.26041
https://doi.org/10.1002/ijc.26041
Autor:
Kazimierz S. Kasprzak, Anna E. Maciag, Malgorzata Romanowska, Keith D. Kikawa, Andrew L. Smith, Janet R. Fields, Laura W. Fornwald, Lucy M. Anderson
Publikováno v:
Free Radical Biology and Medicine. 43:1145-1155
DNA single-strand breaks (quantitative comet assay) were assessed to indicate ongoing genetic instability in a panel of human lung adenocarcinoma cell lines. Of these, 19/20 showed more DNA damage than a nontransformed cell line from human peripheral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e14f8e7662f58d3ae49df1f676825d
https://doi.org/10.1016/j.freeradbiomed.2007.07.004
https://doi.org/10.1016/j.freeradbiomed.2007.07.004
Publikováno v:
Oncogene. 24:1847-1859
The ErbB3 receptor and the downstream signaling kinase Akt are implicated in proliferation of lung adenocarcinoma cells. Inhibition by siRNAs to ErbB3 and Akt isoforms 1, 2 and 3 was utilized to investigate the contribution of these molecules to tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8093b7db7bb875f7cea5d2874fc5754c
https://doi.org/10.1038/sj.onc.1208381
https://doi.org/10.1038/sj.onc.1208381
Autor:
Lucy M. Anderson, Kazimierz S. Kasprzak, Yih-Horng Shiao, W. Gregory Alvord, Octavio A. Quiñones, Joshua Spurrier, Cuiju Wang, Janet R. Fields, Xin Ge, Sean D. McCann, Craig L. Driver, Ralph E. Wilson, Laura W. Fornwald, Lisa Riffle, Erik B. Crawford, Gregory Travlos, Robert M. Leighty
Publikováno v:
Environmental and molecular mutagenesis. 53(5)
Both gene methylation changes and genetic instability have been noted in offspring of male rodents exposed to radiation or chemicals, but few specific gene targets have been established. Previously, we identified the gene for ribosomal RNA, rDNA, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b190b6c7b2411f674313c826d82fa8
https://pubmed.ncbi.nlm.nih.gov/22674528
https://pubmed.ncbi.nlm.nih.gov/22674528
Publikováno v:
The FASEB Journal. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::917859452d25ea6dedaf72c5d0744a26
https://doi.org/10.1096/fasebj.20.4.a146-a
https://doi.org/10.1096/fasebj.20.4.a146-a
Autor:
Lucy M. Anderson, Yih-Horng Shiao, Kazimierz S. Kasprzak, Keith D. Kikawa, Janet R. Fields, S. Lynn North, Anna E. Maciag, Malgorzata Romanowska
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 55(1)
Selenium is an essential nutrient, a component of several anti-oxidant enzymes, and a possible factor in cancer risk, including lung cancer. We determined the subtoxic range of selenium concentration (as sodium selenite) required to increase and main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b1e2971d339ceef544ae8e237233d6
https://pubmed.ncbi.nlm.nih.gov/17052796
https://pubmed.ncbi.nlm.nih.gov/17052796
Publikováno v:
American journal of respiratory cell and molecular biology. 33(5)
In many human lung adenocarcinoma cell lines, a pathway involving epidermal growth factor receptor (EGFR), ErbB2 and ErbB3 receptors, phosphatidyl inositol 3-kinase (PI3K), Akt, glycogen synthase kinase 3-beta (GSK3-beta), and cyclin D1 controls cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f52200f5b62afb803a1de2bf279af4d
https://pubmed.ncbi.nlm.nih.gov/16055672
https://pubmed.ncbi.nlm.nih.gov/16055672
Publikováno v:
Cell Death & Disease
Bidirectional non-protein-coding RNAs are ubiquitously transcribed from the genome. Convergent sense and antisense transcripts may regulate each other. Here, we examined the convergent cis-noncoding rRNAs (nc-rRNAs) in A5 and E9 lung cancer models. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9465b99573873d2e8267db709ba83e
http://europepmc.org/articles/PMC3317346
http://europepmc.org/articles/PMC3317346