Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Janet M. Sigmund"'
Autor:
John A. Beutler, Trong D. Tran, Namki Cho, Janet M. Sigmund, Robert H. Cichewicz, Michael Goetz, Tanya T. Ransom
Publikováno v:
Journal of Natural Products. 80:2037-2044
Bioassay-guided fractionation of a colon cancer growth inhibitory extract of the fungus Paraconiothyrium sp. led to the isolation of eight new versiol derivatives (1, 3-8, 10) along with two known compounds. The structures were elucidated by interpre
Autor:
John W. Phillips, Jesús Martín, Michael A. Goetz, Sheo B. Singh, Janet M. Sigmund, Jon D. Polishook, Francisca Vicente, Karen Dorso, Scott K. Smith, Judyann Wiltsie, Scott P. Salowe, Deborah L. Zink, Russell Onishi, Olga Genilloud, Robert G. K. Donald, Mercedes de la Cruz, John J. Allocco
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7127-7130
Emergence of bacterial resistance has eroded the effectiveness of many life saving antibiotics leading to an urgent need for new chemical classes of antibacterial agents. We have applied a Staphylococcus aureus fitness test strategy to natural produc
Autor:
Gary S. Kath, Mercedes de la Cruz, Jesús Martín, Javier Pascual, Olga Genilloud, Marina Sánchez-Hidalgo, Francisca Vicente, Prakash Masurekar, Gerald F. Bills, Janet M. Sigmund
Publikováno v:
Antonie Van Leeuwenhoek
Despite the availability of many culture-based antibiotic screening methods, the lack of sensitive automated methods to identify functional molecules directly from microbial cells still limits the search for new biologically active compounds. The eff
Autor:
Michael A. Goetz, Keith C. Silverman, Jerrold M. Liesch, Russell B. Lingham, Sheo B. Singh, Janet M. Sigmund
Publikováno v:
The Journal of Organic Chemistry. 60:7896-7901
Autor:
Janet M. Sigmund, Isabel Martin, Olga Genilloud, Russell B. Lingham, Magda M. Gagliardi, Brian Heimbuch, Jackson B. Gibbs, Suzanne E. Gartner, Mary Nallin-Omstead, Gregory E. Koch, Sheo B. Singh, George M. Garrity, Carmen Cascales, Manuel Sanchez, Maria Teresa Diez, Charles F. Hirsch, Keith C. Silverman
Publikováno v:
Applied Microbiology and Biotechnology. 43:610-616
Actinoplanic acids A and B are macrocyclic polycarboxylic acids that are potent reversible inhibitors of farnesyl-protein transferase. Actinoplanic acids A and B were isolated from Actinoplanes sp. MA 7066 while actinoplanic acid B was isolated from
Autor:
Scott K. Smith, Michael A. Goetz, John J. Allocco, Francisca Vicente, Deborah L. Zink, John W. Phillips, Katherine Young, Jesús Martín, Jun Lu, Ronald E. Painter, Robert G. K. Donald, Mercedes de la Cruz, Suzy Lee, Sheo B. Singh, Karen Dorso, Olga Genilloud, Jon D. Polishook, Judyann Wiltsie, Janet M. Sigmund, Russell Onishi, Karen M. Overbye, Stephen Skwish, Scott P. Salowe
Publikováno v:
Chemistrybiology. 18(8)
SummaryBacterial resistance to known therapeutics has led to an urgent need for new chemical classes of antibacterial agents. To address this we have applied a Staphylococcus aureus fitness test strategy to natural products screening. Here we report
Autor:
Russell B. Lingham, George M. Garrity, Maria Teresa Diez, Olga Genilloud, Nancy N. Tsou, Suzanne E. Gartner, Charles F. Hirsch, D. L. Zink, Brian Heimbuch, Gregory E. Koch, Amy Hsu, Manuel Sanchez, Isabel Martin, Jerrold M. Liesch, Gino Salituro, Magda M. Gagliardi, Janet M. Sigmund, Julie A. O'Brien
Publikováno v:
ChemInform. 27
Autor:
Francisca Vicente, Doris F. Cully, Angela Basilio, Jun Wang, Chaowei Zhang, Judith I. Ventura, Dennis M. Schmatz, Phil Youngman, Srinivas Kodali, John F. Barrett, Sookhee Ha, José R. Tormo, Kithsiri Herath, Ronald E. Painter, Hiranthi Jayasuriya, Lynn L. Silver, Katherine Young, Sheo B. Singh, Yingcong Zheng, John G. Ondeyka, Janet M. Sigmund, Robert T. Yamamoto, Vickie Brown-Driver, Fernando Pelaez, Andrew Galgoci
Publikováno v:
Antimicrobial agents and chemotherapy. 50(2)
Condensing enzymes are essential in type II fatty acid synthesis and are promising targets for antibacterial drug discovery. Recently, a new approach using a xylose-inducible plasmid to express antisense RNA in Staphylococcus aureus has been describe
Autor:
Charles F. Hirsch, Janet M. Sigmund
Publikováno v:
The Journal of antibiotics. 51(9)
The antifungal antibiotic rustmicin was detected in the fermentation broth of the actinomycete MA 7094 as a specific inhibitor of sphingolipid biosynthesis in Candida albicans and as a potent fungicidal agent against Cryptococcus neoformans. Taxonomi
Autor:
George M. Garrity, Amy Hsu, Suzanne E. Gartner, Brian Heimbuch, Russell B. Lingham, Charles F. Hirsch, Magda M. Gagliardi, Gregory E. Koch, Manuel Sanchez, Julie A. O'Brien, Deborah L. Zink, Jerrold M. Liesch, Gino Salituro, Janet M. Sigmund, Olga Genilloud, Nancy N. Tsou, Isabel Martin, Maria Teresa Diez
Publikováno v:
The Journal of antibiotics. 49(3)
Quinoxapeptin A and B are novel chromodepsipeptides which were isolated from a nocardioform actinomycete with indeterminant morphology. Quinoxapeptins A and B are potent inhibitors of HIV-1 and HIV-2 reverse transcriptase and almost equally active ag