Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Janet M. Benson"'
Autor:
Janet M. Benson, Gensheng Wang, Julie A. Hutt, Guodong Wu, Stephen M. Kaminsky, Sara Cram, Rajeshkumar Barur, J. Kevin Donahue
Publikováno v:
Basic & Clinical Pharmacology & Toxicology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e8a4ecc064650d3a1a46cbb4968e1a6
https://doi.org/10.1111/bcpt.13885
https://doi.org/10.1111/bcpt.13885
Autor:
Gensheng Wang, Christopher H Evans, Janet M Benson, Julie A Hutt, JeanClare Seagrave, Julie A Wilder, Joshua C Grieger, R Jude Samulski, Pramod S Terse
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Interleukin-1 (IL-1) plays an important role in the pathophysiology of osteoarthritis (OA), and gene transfer of IL-1 receptor antagonist (IL-1Ra) holds promise for OA treatment. A preclinical safety and biodistribution study evaluated a self-complem
Externí odkaz:
https://doaj.org/article/6c9baaef7b4e465f9ba978ec9d3129c7
Autor:
Qiushi Tang, Gensheng Wang, Christian Mueller, Gwladys Gernoux, Dave R. Knop, Louis G. Chicoine, Terence R. Flotte, Kristen E. Coleman, Allison M. Keeler, Alisha M. Gruntman, Guo-jie Ye, Janet M. Benson, Jeffrey D. Chulay
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss, Pp 233-242 (2019)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Phase 1 and phase 2 gene therapy trials using intramuscular (IM) administration of a recombinant adeno-associated virus serotype 1 (rAAV1) for replacement of serum alpha-1 antitrypsin (AAT) deficiency have shown long-term (5-year) stable transgene ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95d4a2cb02817c18dc255b4bf3f9bb1
http://www.sciencedirect.com/science/article/pii/S2329050119300166
http://www.sciencedirect.com/science/article/pii/S2329050119300166
Autor:
Thomas J. Conlon, Janet M. Benson, JeanClare Seagrave, John F. Engelhardt, William B. Guggino, Liudmila Cebotaru, Ziying Yan, Guangping Gao
Publikováno v:
Human Gene Therapy Clinical Development. 28:145-156
Cystic fibrosis (CF) is an autosomal recessive disease that is potentially treatable by gene therapy. Since the identification of the gene encoding CF transmembrane conductance regulator, a number of preclinical and clinical trials have been conducte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32eb0552edfc423d1f7a6fcc40728a65
https://doi.org/10.1089/humc.2017.067
https://doi.org/10.1089/humc.2017.067
Autor:
Janet M. Benson, Thomas J. Conlon, Manuela Corti, Nathalie Clement, Davis Fuller, Roland W. Herzog, Kaitlyn J. Faris, Barry J. Byrne, Brian Cleaver, Gensheng Wang, Alice F. Tarantal
Publikováno v:
Human Gene Therapy Clinical Development. 26:185-193
A recombinant serotype 9 adeno-associated virus (rAAV9) vector carrying a transgene that expresses codon-optimized human acid alpha-glucosidase (hGAA, or GAA) driven by a human desmin (DES) promoter (i.e., rAAV9-DES-hGAA) has been generated as a clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea088743634994892990f226d68ba30
https://doi.org/10.1089/humc.2015.068
https://doi.org/10.1089/humc.2015.068
Autor:
Jeneé M Bevett-Rose, Susan Sepelak, James M. Wilson, Terence R. Flotte, Johannes C.M. Van der Loo, Janet M. Benson, Julie Johnston, Cheryl L. McDonald, Margaret Diggins, Kenneth Cornetta, Eric Daniels
Publikováno v:
Human gene therapy. Clinical development. 28(4)
Over a 10-year period, the Gene Therapy Resource Program (GTRP) of the National Heart Lung and Blood Institute has provided a set of core services to investigators to facilitate the clinical translation of gene therapy. These services have included a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764b95a54d73afbb47b895ab53d545fe
https://pubmed.ncbi.nlm.nih.gov/29130351
https://pubmed.ncbi.nlm.nih.gov/29130351
Autor:
Janet M. Benson, Pramod S. Terse, Julie A. Wilder, Julie A. Hutt, Joshua C Grieger, Gensheng Wang, R. Jude Samulski, Christopher H. Evans, JeanClare Seagrave
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Interleukin-1 (IL-1) plays an important role in the pathophysiology of osteoarthritis (OA), and gene transfer of IL-1 receptor antagonist (IL-1Ra) holds promise for OA treatment. A preclinical safety and biodistribution study evaluated a self-complem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5030c3b64834c124dc36b24d7092214
http://www.sciencedirect.com/science/article/pii/S2329050116301425
http://www.sciencedirect.com/science/article/pii/S2329050116301425
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 74:875-885
Sulfur mustard (SM), a vessicating agent, has been used in chemical warfare since 1918. The purpose of this study was to quantitate SM vapor deposition, tissue distribution, and excretion following intratracheal inhalation in rats and cutaneous expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bcf7bc90a32f84894f99d3b09cac38b
https://doi.org/10.1080/15287394.2011.567959
https://doi.org/10.1080/15287394.2011.567959
Publikováno v:
Inhalation Toxicology. 23:247-256
Ricin is a highly toxic ribosome-inactivating protein derived from the castor bean (Ricinus communis). Due to the relative ease of producing ricin, it is characterized as a category B priority pathogen by the Center for Disease Control and Prevention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76068b40c43112970f97b100891bb43d
https://doi.org/10.3109/08958378.2011.565490
https://doi.org/10.3109/08958378.2011.565490
Autor:
Thomas H. March, Edward B. Barr, Charles R. Clark, Brad M. Tibbetts, Betty J. Skipper, Janet M. Benson, Andrew P. Gigliotti, Lorraine Twerdok
Publikováno v:
Journal of Toxicology and Environmental Health. Part a
Chronic inhalation studies were conducted to compare the toxicity and potential carcinogenicity of evaporative emissions from unleaded gasoline (GVC) and gasoline containing the oxygenate methyl tertiary-butyl ether (MTBE; GMVC). The test materials w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231a4c41f935aa1830b8ffbac7f9c051
https://doi.org/10.1080/15287394.2011.538837
https://doi.org/10.1080/15287394.2011.538837