Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Janet M. Beanan"'
Autor:
Thomas A. Russo, Akshay Manohar, Janet M. Beanan, Ruth Olson, Ulrike MacDonald, Jessica Graham, Timothy C. Umland
Publikováno v:
mSphere, Vol 1, Iss 3 (2016)
ABSTRACT Identification and validation is the first phase of target-based antimicrobial development. BfmR (RstA), a response regulator in a two-component signal transduction system (TCS) in Acinetobacter baumannii, is an intriguing potential antimicr
Externí odkaz:
https://doaj.org/article/0bbb530e852f461ea2681f39154ed515
Autor:
Timothy C. Umland, L. Wayne Schultz, Ulrike MacDonald, Janet M. Beanan, Ruth Olson, Thomas A. Russo
Publikováno v:
mBio, Vol 3, Iss 4 (2012)
ABSTRACT A critical feature of a potential antimicrobial target is the characteristic of being essential for growth and survival during host infection. For bacteria, genome-wide essentiality screens are usually performed on rich laboratory media. Thi
Externí odkaz:
https://doaj.org/article/491cd2e6833c4b1487eafbb994a6b2da
Autor:
Ruth Olson, Janet M. Beanan, Shun Xin Wang-Lin, Thomas A. Russo, Joseph P. Balthasar, Ulrike MacDonald
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 368:475-489
Acinetobacter baumannii has become a pathogen of increasing medical importance because of the emergence of multidrug-resistant strains and the high rate of mortality of infected patients. Promising animal study results have been reported recently wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::956d27ea6483c62a2c6c6ba4717c89fa
https://doi.org/10.1124/jpet.118.253617
https://doi.org/10.1124/jpet.118.253617
Autor:
Thomas A Russo, Alyssa S Shon, Janet M Beanan, Ruth Olson, Ulrike MacDonald, Alexander O Pomakov, Mark P Visitacion
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26734 (2011)
A new hypervirulent (hypermucoviscous) clinical variant of Klebsiella pneumoniae (hvKP) has emerged over the last decade. Our goal is to identify new mechanisms, which increase the virulence hvKP compared to "classic" K. pneumoniae (cKP).Various grow
Externí odkaz:
https://doaj.org/article/de434ad9491b4ef08ecdf87f45cd7749
Autor:
Shun Xin, Wang-Lin, Ruth, Olson, Janet M, Beanan, Ulrike, MacDonald, Thomas A, Russo, Joseph P, Balthasar
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 368(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d9d7b1dbce6722cb4ee8db534c93982
https://pubmed.ncbi.nlm.nih.gov/30606761
https://pubmed.ncbi.nlm.nih.gov/30606761
Publikováno v:
Infection and Immunity. 83:3325-3333
The siderophore aerobactin is the dominant siderophore produced by hypervirulent Klebsiella pneumoniae (hvKP) and was previously shown to be a major virulence factor in systemic infection. However, strains of hvKP commonly produce the additional side
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389d2f253bec4e5ac60f7e03b71b0ff7
https://doi.org/10.1128/iai.00430-15
https://doi.org/10.1128/iai.00430-15
Autor:
Ulrike MacDonald, Thomas A. Russo, L.W. Schultz, Ruth Olson, J. Breen, K.A. Sutton, Janet M. Beanan, Timothy C. Umland
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 71:1736-1744
Acinetobacter baumanniiis an opportunistic Gram-negative pathogen that is an important cause of healthcare-associated infections exhibiting high mortality rates. Clinical isolates of multidrug-resistant (MDR) and extremely drug-resistant (XDR)A. baum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5fc8fa56025e6f838b20d16d9850c7
https://doi.org/10.1107/s139900471501189x
https://doi.org/10.1107/s139900471501189x
Autor:
Ruth Olson, Janet M. Beanan, Ulrike MacDonald, Shun Xin Wang-Lin, Joseph P. Balthasar, Thomas A. Russo
Publikováno v:
Infection and immunity. 85(12)
Acinetobacter baumannii has become an important concern for human health due to rapid development and wide spread of antimicrobial-resistant strains and high mortality associated with the infection. Passive immunizations with antisera targeting outer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d9eac9e9858b5fba0c9564cae8917a
https://pubmed.ncbi.nlm.nih.gov/28947651
https://pubmed.ncbi.nlm.nih.gov/28947651
Autor:
Ruth Olson, Janet M. Beanan, Ulrike MacDonald, Thomas A. Russo, Akshay Manohar, Timothy C. Umland, Jessica Graham
Publikováno v:
mSphere, Vol 1, Iss 3, p e00082-16 (2016)
mSphere, Vol 1, Iss 3 (2016)
mSphere
mSphere, Vol 1, Iss 3 (2016)
mSphere
Increasing antibiotic resistance in bacteria, particularly Gram-negative bacilli, has significantly affected the ability of physicians to treat infections, with resultant increased morbidity, mortality, and health care costs. In fact, some strains of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4231ac350748fb19e8b5aa553d642f5d
https://doaj.org/article/62602c2f45d64340bb5e3a1853e187d0
https://doaj.org/article/62602c2f45d64340bb5e3a1853e187d0
Autor:
Thomas A. Russo, Qingli Kong, Alexander O. Pomakov, Alyssa S. Shon, Daniel J. Metzger, Ruth Olson, Janet M. Beanan, Ulrike MacDonald
Publikováno v:
Virulence. 3:309-318
A new hypervirulent (hypermucoviscous) clinical variant of Klebsiella pneumoniae (hvKP) has emerged over the last decade. Our goal is to identify new mechanisms, which increase the virulence hvKP. It has been shown that hvKP strains produce more biof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a2c75fb4fc5c182db60d1f364940f4
https://doi.org/10.4161/viru.20383
https://doi.org/10.4161/viru.20383