Zobrazeno 1 - 10
of 544
pro vyhledávání: '"Janet M Thornton"'
Autor:
Dobril K Ivanov, Gerrit Bostelmann, Benoit Lan-Leung, Julie Williams, Linda Partridge, Valentina Escott-Price, Janet M Thornton
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240824 (2020)
Many research teams perform numerous genetic, transcriptomic, proteomic and other types of omic experiments to understand molecular, cellular and physiological mechanisms of disease and health. Often (but not always), the results of these experiments
Externí odkaz:
https://doaj.org/article/6068a9a4d81d4ad394c90a57122c1eda
Autor:
Matías Fuentealba, Handan Melike Dönertaş, Rhianna Williams, Johnathan Labbadia, Janet M Thornton, Linda Partridge
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 1, p e1006639 (2019)
Advancing age is the dominant risk factor for most of the major killer diseases in developed countries. Hence, ameliorating the effects of ageing may prevent multiple diseases simultaneously. Drugs licensed for human use against specific diseases hav
Externí odkaz:
https://doaj.org/article/95a4b71c0e8a4251acb82442bba185fa
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147952 (2016)
The relationship between enzyme-catalysed reactions and the Enzyme Commission (EC) number, the widely accepted classification scheme used to characterise enzyme activity, is complex and with the rapid increase in our knowledge of the reactions cataly
Externí odkaz:
https://doaj.org/article/3f79657a12ae4320bebefd124bc368e3
Autor:
Nazif Alic, T Daniel Andrews, Maria E Giannakou, Irene Papatheodorou, Cathy Slack, Matthew P Hoddinott, Helena M Cochemé, Eugene F Schuster, Janet M Thornton, Linda Partridge
Publikováno v:
Molecular Systems Biology, Vol 7, Iss 1, Pp 1-17 (2011)
Abstract FoxO transcription factors, inhibited by insulin/insulin‐like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan. Using genomic tools, we uncover over 700 direct dFOXO targets in adult f
Externí odkaz:
https://doaj.org/article/a19fe5b02a51451f857cd72f46fb2aa1
Autor:
Eugene Schuster, Joshua J McElwee, Jennifer M A Tullet, Ryan Doonan, Filip Matthijssens, John S Reece‐Hoyes, Ian A Hope, Jacques R Vanfleteren, Janet M Thornton, David Gems
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp 1-6 (2010)
Abstract Insulin/IGF‐1 signaling controls metabolism, stress resistance and aging in Caenorhabditis elegans by regulating the activity of the DAF‐16/FoxO transcription factor (TF). However, the function of DAF‐16 and the topology of the transcr
Externí odkaz:
https://doaj.org/article/b9eb08e657cd45f9974a10a8b7a962cb
Autor:
Jonathan J Ward, Janet M Thornton
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 10, Pp 1993-2002 (2007)
Many natural and artificial networks contain overrepresented subgraphs, which have been termed network motifs. In this article, we investigate the processes that led to the formation of the two most common network motifs in eukaryote transcription fa
Externí odkaz:
https://doaj.org/article/99ef257cc5594c5f91855c24f4925fe9
Autor:
Nidhi Tyagi, Edward J Farnell, Colin M Fitzsimmons, Stephanie Ryan, Edridah Tukahebwa, Rick M Maizels, David W Dunne, Janet M Thornton, Nicholas Furnham
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 10, p e1004546 (2015)
Allergic reactions can be considered as maladaptive IgE immune responses towards environmental antigens. Intriguingly, these mechanisms are observed to be very similar to those implicated in the acquisition of an important degree of immunity against
Externí odkaz:
https://doaj.org/article/dd58467b718543aca24a62c32fee7896
Autor:
Jennifer M A Tullet, Caroline Araiz, Matthew J Sanders, Catherine Au, Alexandre Benedetto, Irene Papatheodorou, Emily Clark, Kathrin Schmeisser, Daniel Jones, Eugene F Schuster, Janet M Thornton, David Gems
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004109 (2014)
The DAF-16/FoxO transcription factor controls growth, metabolism and aging in Caenorhabditis elegans. The large number of genes that it regulates has been an obstacle to understanding its function. However, recent analysis of transcript and chromatin
Externí odkaz:
https://doaj.org/article/3555a38cc4584a5d9b789216555d1390
Autor:
Tjaart A P de Beer, Roman A Laskowski, Sarah L Parks, Botond Sipos, Nick Goldman, Janet M Thornton
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 12, p e1003382 (2013)
The 1000 Genomes Project data provides a natural background dataset for amino acid germline mutations in humans. Since the direction of mutation is known, the amino acid exchange matrix generated from the observed nucleotide variants is asymmetric an
Externí odkaz:
https://doaj.org/article/2dee5efa98f44270bc3c08090e703767
Autor:
Irene Papatheodorou, Matthias Ziehm, Daniela Wieser, Nazif Alic, Linda Partridge, Janet M Thornton
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50881 (2012)
A challenge of systems biology is to integrate incomplete knowledge on pathways with existing experimental data sets and relate these to measured phenotypes. Research on ageing often generates such incomplete data, creating difficulties in integratin
Externí odkaz:
https://doaj.org/article/d33dc7059f154716bc11f6c07d81d475