Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Janet Lei-Rossmann"'
Autor:
Daniel Ebner, Olaf Ansorge, Hena Khalique, Richard Baugh, Janet Lei-Rossmann, Emma Page, Peter Kok-Ting Wan, Leonard W Seymour, Timothy Johanssen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)
Background Glioblastoma (GBM) almost invariably becomes resistant towards conventional treatment of radiotherapy and temozolomide (TMZ) chemotherapy, partly due to subpopulations of intrinsically resistant glioma stem-like cells (GSC). The oncolytic
Externí odkaz:
https://doaj.org/article/c51c561733e644468744f3bff707e850
Autor:
William K. Taverner, Egon J. Jacobus, John Christianson, Brian Champion, Adrienne W. Paton, James C. Paton, Weiheng Su, Ryan Cawood, Len W. Seymour, Janet Lei-Rossmann
Publikováno v:
Molecular Therapy: Oncolytics, Vol 15, Iss , Pp 117-130 (2019)
Oncolytic viruses represent an emerging approach to cancer therapy. However, better understanding of their interaction with the host cancer cell and approaches to enhance their efficacy are needed. Here, we investigate the effect of chemically induce
Externí odkaz:
https://doaj.org/article/ed0fdf30ec0b400b8953b021722314be
Autor:
Hena Khalique, Richard Baugh, Arthur Dyer, Eleanor M. Scott, Sally Frost, Sarah Larkin, Janet Lei-Rossmann, Leonard W. Seymour
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)
Background Programmed death-ligand 1 (PD-L1) is an important immune checkpoint protein that can be regarded as a pan-cancer antigen expressed by multiple different cell types within the tumor. While antagonizing PD-L1 is well known to relieve PD-1/PD
Externí odkaz:
https://doaj.org/article/6903c64ec4004e1ea2bd2210441945da
Autor:
Kerry D. Fisher, Leonard W. Seymour, Brian R. Champion, Paul Miller, Adam Lambert, Clare Verrill, Richard J. Bryant, Leticia Campo, Joachim Hagel, Eleanor M. Scott, Alice Muntzer, Janet Lei-Rossmann, Margaret R. Duffy, Joshua D. Freedman
Supplementary Files detailing additional experiments supporting the conclusions of the manuscript, including additional activation, cytotoxicity, and cytokine analyses. Supplementary tables contain more details on characterisation of patient biopsies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485e705c7efbfb716257f1d09ff10e04
https://doi.org/10.1158/0008-5472.22419483
https://doi.org/10.1158/0008-5472.22419483
Autor:
Kerry D. Fisher, Leonard W. Seymour, Brian R. Champion, Paul Miller, Adam Lambert, Clare Verrill, Richard J. Bryant, Leticia Campo, Joachim Hagel, Eleanor M. Scott, Alice Muntzer, Janet Lei-Rossmann, Margaret R. Duffy, Joshua D. Freedman
Time-lapse sequence of uninfected control cultures of DLD, NHDF, and T cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2faf0839ee83d77b36795cc68ec037f
https://doi.org/10.1158/0008-5472.22419492.v1
https://doi.org/10.1158/0008-5472.22419492.v1
Autor:
Kerry D. Fisher, Leonard W. Seymour, Brian R. Champion, Paul Miller, Adam Lambert, Clare Verrill, Richard J. Bryant, Leticia Campo, Joachim Hagel, Eleanor M. Scott, Alice Muntzer, Janet Lei-Rossmann, Margaret R. Duffy, Joshua D. Freedman
Effective immunotherapy of stromal-rich tumors requires simultaneous targeting of cancer cells and immunosuppressive elements of the microenvironment. Here, we modified the oncolytic group B adenovirus enadenotucirev to express a stroma-targeted bisp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c1027b95bdb83ff43117766fe19c258
https://doi.org/10.1158/0008-5472.c.6510393.v1
https://doi.org/10.1158/0008-5472.c.6510393.v1
Autor:
Syahril Abdullah, Tiong-Kit Tan, Janet Lei-Rossmann, Khatijah Yusoff, Adelene Ai-Lian Song, Suet Lin Chia, Ming Yue Yeong, Pheik-Sheen Cheow
Publikováno v:
Journal of virological methods. 291
The development of a T7 RNA polymerase (T7 RNAP) expressing cell line i.e. BSR T7/5 cells marks an improvement of reverse genetics for the recovery of recombinant Newcastle disease virus (rNDV). BSR T7/5 is developed by transient transfection of plas
Autor:
Egon J. Jacobus, William K. Taverner, Arthur Dyer, Tzveta D. Pokrovska, Kerry D. Fisher, Janet Lei-Rossmann, Katharine J. Herbert, Richard Baugh, Geoff S. Higgins, Gonzalo Rodriguez-Berriguete, Rathi Puliyadi, Remko Prevo, Brian R. Champion, Len Seymour, Giovanna Granata, Sally Frost
Publikováno v:
Cancers
Volume 12
Issue 4
Cancers, Vol 12, Iss 4, p 798 (2020)
Volume 12
Issue 4
Cancers, Vol 12, Iss 4, p 798 (2020)
Ionising radiation causes cell death through the induction of DNA damage, particularly double-stranded DNA (dsDNA) breaks. Evidence suggests that adenoviruses inhibit proteins involved in the DNA damage response (DDR) to prevent recognition of double
Publikováno v:
Cancer Immunology Research. 10:P024-P024
Glioblastoma (GBM) is one of the most aggressive and immunosuppressive brain tumors in adults. Despite conventional therapy of surgical resection, radiotherapy and temozolomide (TMZ) chemotherapy, tumors invariably recur and become resistant. The Nat
Autor:
Eleanor M, Scott, Sally, Frost, Hena, Khalique, Joshua D, Freedman, Len W, Seymour, Janet, Lei-Rossmann
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2058
The translational success of oncolytic virotherapies would benefit from the widespread use of clinically relevant ex vivo models. Malignant ascites, an accumulation of fluid in the peritoneum due to disseminated cancer, recapitulates many features of