Výsledky vyhledávání - "Janet L. Wieber"

Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility

Autor: Janet L. Wieber, James A. Nieman, Herbert M. Zerth, Brenda L. Schultz, Steven E. Heasley, Nancee L. Oien, Mary L. Knechtel, Ke Chen, Todd A. Hopkins, Michael W. Wathen, Kevin J. Stephanski, Richard A. Nugent, Sajiv Krishnan Nair

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:3039-3042

A series of C-2 pyrroloquinoline analogs designed to improve aqueous solubility were examined for herpesvirus polymerase and antiviral activity. Several analogs were identified that maintained the antiviral activity of the previous development candid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0e5a07e78eeadbc4cabdd1f4e0e5e2
https://doi.org/10.1016/j.bmcl.2010.03.115

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4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as Non-Nucleoside Inhibitors of Human Cytomegalovirus and Related Herpesvirus Polymerases

Autor: Mary L. Knechtel, Michael W. Wathen, Fred L. Homa, Janet L. Wieber, Michele M. Cudahy, Thomas W. Pitts, Roger A. Poorman, Nancee L. Oien, Mark E. Schnute, Todd A. Hopkins, Roger J. Brideau

Publikováno v: Journal of Medicinal Chemistry. 48:5794-5804

A novel series of 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potential antivirals against human herpesvirus infections resulting from human cytomegalovirus (HCMV), herpes simplex virus type 1 (HSV-1), and varicella-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45b73ecc9d7de70e829ac53f7d84990
https://doi.org/10.1021/jm050162b

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Broad-spectrum antiviral activity of PNU-183792, a 4-oxo-dihydroquinoline, against human and animal herpesviruses

Autor: Nancee L. Oien, Janet L. Wieber, Vaillancourt Valerie A, Ellen E. Vera, Michael W. Wathen, Todd A. Hopkins, Mary L. Knechtel, Karen F. Wilkinson, Bob D. Rush, Roger J. Brideau, Francis J. Schwende, Audris Huang

Publikováno v: Antiviral Research. 54:19-28

We identified a novel class of 4-oxo-dihydroquinolines represented by PNU-183792 which specifically inhibit herpesvirus polymerases. PNU-183792 was highly active against human cytomegalovirus (HCMV, IC(50) value 0.69 microM), varicella zoster virus (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a29c69ab590c6c77dc4eb85200c43a
https://doi.org/10.1016/s0166-3542(01)00208-x

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Broad-Spectrum Antiherpes Activities of 4-Hydroxyquinoline Carboxamides, a Novel Class of Herpesvirus Polymerase Inhibitors

Autor: John A. Tucker, Roger A. Poorman, Nancee L. Oien, Roger J. Brideau, Todd A. Hopkins, John A. Shelly, Janet L. Wieber, Michael W. Wathen, Mary L. Knechtel, Audris Huang, Robert A. Anstadt, Peter A. Wells, Vallerie A. Vaillancourt, Terrance L. Clayton

Publikováno v: Antimicrobial Agents and Chemotherapy. 46:724-730

Through broad screening of the compound library at Pharmacia, a naphthalene carboxamide was identified as a nonnucleoside inhibitor of human cytomegalovirus (HCMV) polymerase. Structure-activity relationship studies demonstrated that a quinoline ring

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d756ea645e3dbcdf2508c075b59eec
https://doi.org/10.1128/aac.46.3.724-730.2002

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The design and development of 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase

Autor: Steven P. Tanis, Nancee L. Oien, Kevin J. Stephanski, Mary L. Knechtel, Janet L. Wieber, Timothy Parker, Perrault William R, Strohbach Joseph Walter, Malcom W. Moon, Todd A. Hopkins, Michael W. Wathen, Suvit Thaisrivongs

Publikováno v: Bioorganicmedicinal chemistry letters. 20(6)

Discovery efforts were focused on identifying a non-nucleoside antiviral for treating infections caused by human cytomegalovirus (HCMV) with equal or better potency and diminished toxicity compared to current therapeutics. This Letter describes the H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a23e0ea623f6b5322cd27fdb772184
https://pubmed.ncbi.nlm.nih.gov/20167488

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Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition

Autor: Mari L. Stephan, Michele M. Cudahy, Janet L. Wieber, Allen Scott, Sarah A. Collier, Robert S. Sackett, Mark E. Schnute, Roger J. Brideau, Todd A. Hopkins, Michael W. Wathen, Nancee L. Oien, Mary L. Knechtel

Publikováno v: Bioorganicmedicinal chemistry letters. 18(14)

A versatile synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxylate esters has been developed which has lead to the identification of a new series of non-nucleoside inhibitors of human herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e376eb4f4e4856fd6930c7111eb0f1
https://pubmed.ncbi.nlm.nih.gov/18595689

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7-Oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides: synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase

Autor: Michael J. Hageman, Janet L. Wieber, Roger J. Brideau, Scott D. Larsen, Stefanski Kevin J, Francis J. Schwende, Mary L. Knechtel, Bob D. Rush, Michael W. Wathen, Peter R. Manninen, Kathyrn M. Zamora, Zhijun Zhang, Todd A. Hopkins, Douglas C. Rohrer, Brian A. DiPaolo, Nancee L. Oien, Karen F. Wilkinson

Publikováno v: Bioorganicmedicinal chemistry letters. 17(14)

We report a new class of non-nucleoside antivirals, the 7-oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides, some of which possess remarkable potency versus a broad spectrum of herpesvirus DNA polymerases and excellent selectivity compared to human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b909b054075c71bf801100ef740fa58
https://pubmed.ncbi.nlm.nih.gov/17513108

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2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

Publikováno v: Bioorganicmedicinal chemistry letters. 17(12)

A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c003e07737e19e2a8033c8a023d0a5f
https://pubmed.ncbi.nlm.nih.gov/17434304

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Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase

Autor: Mary L. Knechtel, Michael W. Wathen, Yoshihiko Yagi, Sandra Staley, Vaillancourt Valerie A, Michele M. Cudahy, Steven J. Conrad, Roger J. Brideau, Janet L. Wieber, Nancee L. Oien

Publikováno v: Bioorganicmedicinal chemistry letters. 10(18)

ortho-Hydroxynaphthalene carboxamides have been identified as inhibitors of HCMV DNA polymerase. SAR investigations have demonstrated that both the amide and hydroxy functionalities are required for activity. Substitution on the naphthalene ring has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d0b9c120eb2d48a22398dcc8013bb4
https://pubmed.ncbi.nlm.nih.gov/10999475

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