Zobrazeno 1 - 10
of 700
pro vyhledávání: '"Janet L. Stein"'
Autor:
Jonathan A. R. Gordon, Coralee E. Tye, Bodhisattwa Banerjee, Prachi N. Ghule, Andre J. van Wijnen, Fleur S. Kabala, Natalie A. Page, Michelle M. Falcone, Janet L. Stein, Gary S. Stein, Jane B. Lian
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The skeleton forms from multipotent human mesenchymal stem cells (hMSCs) competent to commit to specific lineages. Long noncoding RNAs (lncRNAs) have been identified as key epigenetic regulators of tissue development. However, regulation of
Externí odkaz:
https://doaj.org/article/22d7cc53663c45a996950aef704e675e
Autor:
Coralee E. Tye, Prachi N. Ghule, Jonathan A. R. Gordon, Fleur S. Kabala, Natalie A. Page, Michelle M. Falcone, Kirsten M. Tracy, Andre J. van Wijnen, Janet L. Stein, Jane B. Lian, Gary S. Stein
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Bone formation requires osteogenic differentiation of multipotent mesenchymal stromal cells (MSCs) and lineage progression of committed osteoblast precursors. Osteogenic phenotype commitment is epigenetically controlled by genomic (chromatin
Externí odkaz:
https://doaj.org/article/cb869d076f7b42c0a921afee30acdf08
Autor:
Jonathan A. R. Gordon, Mark F. Evans, Prachi N. Ghule, Kyra Lee, Pamela Vacek, Brian L. Sprague, Donald L. Weaver, Gary S. Stein, Janet L. Stein
Publikováno v:
PLoS ONE, Vol 18, Iss 3 (2023)
The tumor microenvironment is a complex mixture of cell types that bi-directionally interact and influence tumor initiation, progression, recurrence, and patient survival. Mesenchymal stromal cells (MSCs) of the tumor microenvironment engage in cross
Externí odkaz:
https://doaj.org/article/07ee23e28a7b40cda37a393569bf4f85
Autor:
Daniela Nachmanson, Adam Officer, Hidetoshi Mori, Jonathan Gordon, Mark F. Evans, Joseph Steward, Huazhen Yao, Thomas O’Keefe, Farnaz Hasteh, Gary S. Stein, Kristen Jepsen, Donald L. Weaver, Gillian L. Hirst, Brian L. Sprague, Laura J. Esserman, Alexander D. Borowsky, Janet L. Stein, Olivier Harismendy
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Microenvironmental and molecular factors mediating the progression of Breast Ductal Carcinoma In Situ (DCIS) are not well understood, impeding the development of prevention strategies and the safe testing of treatment de-escalation. We addre
Externí odkaz:
https://doaj.org/article/25a046ee37fb400db82cd80023557ef6
Autor:
Xiangguo Che, Xian Jin, Na Rae Park, Hee-June Kim, Hee-Soo Kyung, Hyun-Ju Kim, Jane B. Lian, Janet L. Stein, Gary S. Stein, Je-Yong Choi
Publikováno v:
Cells, Vol 12, Iss 7, p 1064 (2023)
TGF-β signaling is a vital regulator for maintaining articular cartilage homeostasis. Runx transcription factors, downstream targets of TGF-β signaling, have been studied in the context of osteoarthritis (OA). Although Runx partner core binding fac
Externí odkaz:
https://doaj.org/article/1b6314ddf1de49f9919e18a88f0a2261
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Leukemia transformed by the CALM-AF10 chromosomal translocation is characterized by a high incidence of extramedullary disease, central nervous system (CNS) relapse, and a poor prognosis. Invasion of the extramedullary compartment and CNS requires le
Externí odkaz:
https://doaj.org/article/4d6d7b2f5d894265a6ada302a0fce785
Autor:
Jennifer J. VanOudenhove, Ricardo Medina, Prachi N. Ghule, Jane B. Lian, Janet L. Stein, Sayyed K. Zaidi, Gary S. Stein
Publikováno v:
Stem Cell Reports, Vol 7, Iss 5, Pp 884-896 (2016)
The transition of human embryonic stem cells (hESCs) from pluripotency to lineage commitment is not fully understood, and a role for phenotypic transcription factors in the initial stages of hESC differentiation remains to be explored. From a screen
Externí odkaz:
https://doaj.org/article/a9e5c3ff6efc4abf84b3fce0893d3b86
Autor:
Joshua L. Rein, Aaron M. Etra, Jatinbhai J. Patel, Janet L. Stein, Aimee L. Rivers, Hayley B. Gershengorn, Elizabeth Awerbuch, Barry N. Kreiswirth, Sanjana C. Koshy
Publikováno v:
Emerging Infectious Diseases, Vol 20, Iss 7, Pp 1258-1260 (2014)
Externí odkaz:
https://doaj.org/article/a03abeb7b5f14007822e60db21a197d9
Autor:
Andrew J. Fritz, Prachi N. Ghule, Rabail Toor, Louis Dillac, Jonah Perelman, Joseph Boyd, Jane B. Lian, Johnathan A. R. Gordon, Seth Frietze, Andre Van Wijnen, Janet L. Stein, Gary S. Stein
Publikováno v:
Critical Reviews in Eukaryotic Gene Expression. 33:85-97
Higher-order genomic organization supports the activation of histone genes in response to cell cycle regulatory cues that epigenetically mediates stringent control of transcription at the G1/S-phase transition. Histone locus bodies (HLBs) are dynamic
Autor:
Jane B. Lian, Gary S. Stein, Janet L. Stein, Jason Stumpff, Heidi L.H. Malaby, Prachi N. Ghule, Coralee E. Tye, Kirsten M. Tracy
MANCR-depleted MDA-MB-231 cells exhibit a more normal-like expression of genes related to cell cycle processes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206252cb8a19beb6c782f0482ee450ee
https://doi.org/10.1158/1541-7786.22513581
https://doi.org/10.1158/1541-7786.22513581