The Sleep Quality- and Myopia-Linked PDE11A-Y727C Variant Impacts Neural Physiology by Reducing Catalytic Activity and Altering Subcellular Compartmentalization of the Enzyme

Autor: Irina Sbornova, Emilie van der Sande, Snezana Milosavljevic, Elvis Amurrio, Steven D. Burbano, Prosun K. Das, Helen H. Do, Janet L. Fisher, Porschderek Kargbo, Janvi Patel, Latarsha Porcher, Chris I. De Zeeuw, Magda A. Meester-Smoor, Beerend H. J. Winkelman, Caroline C. W. Klaver, Ana Pocivavsek, Michy P. Kelly

Publikováno v: Cells, Vol 12, Iss 24, p 2839 (2023)

Recently, a Y727C variant in the dual-specific 3′,5′-cyclic nucleotide phosphodiesterase 11A (PDE11A-Y727C) was linked to increased sleep quality and reduced myopia risk in humans. Given the well-established role that the PDE11 substrates cAMP an

Externí odkaz: https://doaj.org/article/afdb21e5db9b413d8cd3d5fd6c0370cf

Conserved age-related increases in hippocampal PDE11A4 cause unexpected proteinopathies and cognitive decline of social associative memories

Autor: Katy Pilarzyk, Latarsha Porcher, William R. Capell, Steven D. Burbano, Jeff Davis, Janet L. Fisher, Nicole Gorny, Siena Petrolle, Michy P. Kelly

Publikováno v: Aging cell. 21(10)

In humans, associative memories are more susceptible to age-related cognitive decline (ARCD) than are recognition memories. Reduced cAMP/cGMP signaling in the hippocampus may contribute to ARCD. Here, we found that both aging and traumatic brain inju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffe1bc18656bb8d36bbda51da6e81c1
https://pubmed.ncbi.nlm.nih.gov/36073342

Contributors

Autor: Mario A. Acuña, Rohit Aiyer, Sergiu Albu, Ahmad Altarifi, Duygun Altıntaş Aykan, María Jesús Álvarez-Cubero, Richard T. Ambron, Verónica Arenas-Rodríguez, Yosuke Arima, Nayara Anitelli Artero, Janete S. Bandeira, Ricardo Becerro-de-Bengoa-Vallejo, Eric J. Bellefroid, Mongi Benjeddou, Sergio Marques Borghi, César Calvo-Lobo, Taís de Campos Lima, Yolanda Campos-Jurado, Thacyana Teixeira Carvalho, Rubia Casagrande, Wolnei Caumo, Rok Cerne, Krishnan Chakravarthy, James M. Cook, Fabiano V. Costa, Sergio Cuenca-López, Javier Cuitavi, Maya D’Eon, Rodolfo Delgado-Lezama, Simon Desiderio, Jairo Alberto Dussan-Sarria, Fernando Estévez-López, Camila Rodrigues Ferraz, Janet L. Fisher, Anelise Franciosi, Úrzula Franco-Enzástiga, Masashi Fujitani, Soudeh Ghafouri-Fard, Lalit K. Golani, Shaila Gowda, Vinicio Granados-Soto, Semih Gungor, Mogge Hajiesmaeil, Hee Chul Han, Natalie Hellman, Luis Eduardo Hernández-Reyes, Lucia Hipólito, S.A. Holmes, Allan V. Kalueff, Fernando Kasanetz, Manal Kassab, Seonghoon Kim, Johann Klein, Daniel E. Knutson, Hannu Kokki, Merja Kokki, Yarim E. De la Luz-Cuellar, Natalia Landsberg, Hans Linsenbardt, Daniel López-López, Jesús D. Lorente, Marta Elena Losa-Iglesias, Celina Monteiro da Cruz Lotufo, Luis Javier Martínez-González, Eva María Martínez-Jiménez, Victoria Mazoteras-Pardo, Mary W. Meagher, Desanka Milanović, Keisuke Miyamoto, Janet Murbartián, Thomas Nevian, Khawla Q. Nuseir, Masahiro Ohsawa, Yoshinori Otani, Antonella Paladini, Sara Palermo, Eui Ho Park, Jeong-wook Park, Vinood B. Patel, Željko Pavković, Ana M. Peiró, Vesna Pešić, M.E. Pierce, Witold H. Polanski, Victor R. Preedy, A. Quinlan, Rajkumar Rajendram, Fernanda Soares Rasquel-Oliveira, Guadalupe Raya-Tafolla, Martina Rekatsina, Jamie L. Rhudy, David Rodríguez-Sanz, Carlos Romero-Morales, Robert Root-Bernstein, Luiz V. Rosa, Denis B. Rosemberg, Thomas Rutledge, Giorgia Saltelli, Marta San-Antolín-Gil, Débora de Oliveira Santos, Telma Saraiva-Santos, Jamie Sleigh, Jodi L. Smith, Maryam Sobhani, Ying-Ju Sung, Charles Akos Szabó, Jorge E. Torres-López, Giustino Varrassi, Vishal Varshney, Simon Vermeiren, Waldiceu A. Verri, Logan Voss, Jeffrey M. Witkin, Zizhen Wu, Qing Yang, Fatemeh Yazarlou, Zainul Amiruddin Zakaria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8af96cb2d8c7da97b4f60106271936bf
https://doi.org/10.1016/b978-0-12-820589-1.09991-7

The α6 GABAA Receptor Positive Allosteric Modulator DK-I-56-1 Reduces Tic-Related Behaviors in Mouse Models of Tourette Syndrome

Autor: Karen Odeh, Stefanos Loizou, Janet L. Fisher, Laura J. Mosher, Roberto Cadeddu, Marco Bortolato, Daniel E. Knutson, James M. Cook

Publikováno v: Biomolecules
Volume 11
Issue 2
Biomolecules, Vol 11, Iss 175, p 175 (2021)

Tourette syndrome (TS) is a disabling neurodevelopmental disorder characterized by multiple, recurrent tics. The pharmacological treatment of TS is currently based on dopaminergic antagonists
however, these drugs are associated with extrapyramid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f543a66a4c71c39140c03747f6b66fa4

A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung

Autor: Gloria S. Forkuo, James M. Cook, Gene T. Yocum, Revathi Kodali, Leggy A. Arnold, Rajwana Jahan, Michael Rajesh Stephen, Margaret L. Guthrie, Douglas A. Steeber, Charles W. Emala, Douglas C. Stafford, Olivia B. Yu, Guanguan Li, Nicolas M Zahn, Ted William Harris, Janet L. Fisher, Amanda N. Nieman, M S Rashid Roni

Publikováno v: Molecular Pharmaceutics. 15:1766-1777

We describe lead compound MIDD0301 for the oral treatment of asthma based on previously developed positive allosteric α(5)β(3)γ(2) selective GABA(A) receptor (GABA(A)R) ligands. MIDD0301 relaxed airway smooth muscle at single micromolar concentrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b93345b08045b2b3af1122f8fda4a35
https://doi.org/10.1021/acs.molpharmaceut.7b01013