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of 10
pro vyhledávání: '"Janet L. Andres"'
Publikováno v:
Experimental Cell Research. 211:301-306
Betaglycan (type III transforming growth factor-beta (TGF-beta) receptor) is a cell surface heparan/chondroitin sulfate proteoglycan that binds TGF-beta via its core protein and is abundantly expressed in osteoblastic cells. A previous report (Centre
Autor:
Liliana Attisano, Fernando López-Casillas, Jeffrey L. Wrana, Sela Cheifetz, Joan Massagué, Masahiko Ohtsuki, Janet L. Andres
Publikováno v:
Molecular Reproduction and Development. 32:99-104
The nature and role of cell surface proteins that bind members of the TGF-beta family has been investigated. TGF-beta, activins, and BMPs each bind to receptors of 55 kDa (type I) and 70 kDa (type II). In the TGF-beta system, these receptors are impl
Publikováno v:
The Journal of Cell Biology
Betaglycan, also known as the TGF-beta type III receptor, is a membrane-anchored proteoglycan that presents TGF-beta to the type II signaling receptor, a transmembrane serine/threonine kinase. The betaglycan extracellular region, which can be shed by
Autor:
Sela Cheifetz, Jacqueline Doody, Janet L. Andres, Fernando López-Casillas, William S. Lane, Joan Massagué
Publikováno v:
Cell. 67(4)
We describe the primary structure of rat betaglycan, a polymorphic membrane-anchored proteoglycan with high affinity for transforming growth factor-beta (TGF-beta). As deduced from its cDNA sequence, the 853 amino acid core protein of betaglycan has
Publikováno v:
Europe PubMed Central
Summary Transforming growth factors-beta (TGFs-β) are representative of a superfamily whose members were first identified as regulators of morphogenesis and differentiation, and subsequently found to be structurally related. Other members of the fam
Publikováno v:
Annals of the New York Academy of Sciences. 593
Publikováno v:
The Journal of Cell Biology
Transforming growth factors beta 1 and beta 2 bind with high affinity to the core protein of a 250-350-kD cell surface proteoglycan. This proteoglycan (formerly referred to as the type III TGF-beta receptor) coexists in many cells with the receptor i
Publikováno v:
Europe PubMed Central
The transforming growth factor-beta (TGF-beta) receptor type III is a low abundance cell surface component that binds TGF-beta 1 and TGF-beta 2 with high affinity and specificity, and is present in many mammalian and avian cell types. Type III TGF-be
Publikováno v:
Europe PubMed Central
Cell surface proteoglycans help present some polypeptide growth factors such as basic fibroblast growth factor (bFGF) to their receptors and may act as reservoirs for others such as transforming growth factor-beta (TGF-beta). Betaglycan, a cell surfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f899f2e3a0518a58c7bd8bc2fc2f56e
http://europepmc.org/abstract/med/1556106
http://europepmc.org/abstract/med/1556106
Publikováno v:
Europe PubMed Central
Lund University
Lund University
We report the purification of betaglycan, a low-abundance membrane proteoglycan with high affinity for transforming growth factor-beta (TGF-beta). Betaglycan solubilized from rat embryo membrane preparations was purified to near-homogeneity by sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c1bef5d2fc619e0f222afb535ec658
http://europepmc.org/abstract/med/1744125
http://europepmc.org/abstract/med/1744125