Zobrazeno 1 - 10
of 322
pro vyhledávání: '"Janet L, Smith"'
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Here the structure of the HEXIM arginine rich motif in complex with the stemloop-1 of 7SK snRNA is determined, and insights are provided into how the HIV protein Tat overcomes the structural constraints required to displace HEXIM, an event required f
Externí odkaz:
https://doaj.org/article/ea02a4180190458eaa18f223ca6122fc
Autor:
Janet L. Smith
Publikováno v:
IUCrJ, Vol 10, Iss 5, Pp 555-556 (2023)
A commentary on Wayne Hendrickson's article `Facing the phase problem'.
Externí odkaz:
https://doaj.org/article/2a8f5ecf6cb14678acd574b1ca47a17e
Autor:
Sergey Stepanov, David Kissick, Oleg Makarov, Mark Hilgart, Michael Becker, Nagarajan Venugopalan, Shenglan Xu, Janet L. Smith, Robert F. Fischetti
Publikováno v:
Journal of Synchrotron Radiation, Vol 29, Iss 2, Pp 393-399 (2022)
Algorithms and procedures to fully automate retuning of synchrotron radiation beamlines over wide energy ranges are discussed. The discussion is based on the implementation at the National Institute of General Medical Sciences and the National Cancer
Externí odkaz:
https://doaj.org/article/59ee18da35e247289676a56fb5c340a9
Publikováno v:
PLoS Genetics, Vol 18, Iss 12, p e1010564 (2022)
DNA replication is essential for all living organisms. Several events can disrupt replication, including DNA damage (e.g., pyrimidine dimers, crosslinking) and so-called "roadblocks" (e.g., DNA-binding proteins or transcription). Bacteria have severa
Externí odkaz:
https://doaj.org/article/a24b8e5c96004e85addac3032feb88f2
Autor:
Shuvasree SenGupta, Lauren E. Hein, Yang Xu, Jason Zhang, Jamie R. Konwerski, Ye Li, Craig Johnson, Dawen Cai, Janet L. Smith, Carole A. Parent
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Tumor associated neutrophils (TANs) are frequently detected in triple-negative breast cancer (TNBC). Recent studies also reveal the importance of neutrophils in promoting tumor progression and metastasis during breast cancer. However, the mechanisms
Externí odkaz:
https://doaj.org/article/b4bdece98600497ea21b6e8993c8645f
Autor:
Vincent V. Pham, Carolina Salguero, Shamsun Nahar Khan, Jennifer L. Meagher, W. Clay Brown, Nicolas Humbert, Hugues de Rocquigny, Janet L. Smith, Victoria M. D’Souza
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The HIV Tat protein recruits a host elongation factor from the cellular 7SK complex to the viral TAR RNA to ensure transcriptional elongation. Here, Pham et al. solve the structures of both 7SK and TAR RNAs in complex with Tat’s RNA binding domain
Externí odkaz:
https://doaj.org/article/e6554c00f39b4f589bd46ef921f677e2
Publikováno v:
ACS chemical biology. 17(8)
Installation of methyl groups can significantly improve the binding of small-molecule drugs to protein targets; however, site-selective methylation often presents a significant synthetic challenge. Metal- and
Autor:
Samantha P. Kelly, Vikram V. Shende, Autumn R. Flynn, Qingyun Dan, Ying Ye, Janet L. Smith, Sachiko Tsukamoto, Matthew S. Sigman, David H. Sherman
Publikováno v:
Journal of the American Chemical Society, vol 144, iss 42
J Am Chem Soc
J Am Chem Soc
Prenyltransfer is an early-stage carbon-hydrogen bond (C-H) functionalization prevalent in the biosynthesis of a diverse array of biologically active bacterial, fungal, plant, and metazoan diketopiperazine (DKP) alkaloids. Toward the development of a
Autor:
Jennifer A. Bohn, Keyur Thummar, Ashley York, Alice Raymond, W. Clay Brown, Paul D. Bieniasz, Theodora Hatziioannou, Janet L. Smith
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
The APOBEC3 family cytidine deaminases with antiviral activity are proteins that catalyze the deamination of newly reverse-transcribed viral DNA. Here the authors present the crystal structure of full-length pig-tailed macaque APOBEC3H with bound RNA
Externí odkaz:
https://doaj.org/article/87b772b400884c0ab80fc87ff5e15102
Publikováno v:
Molecular Microbiology. 118:426-442
DNA replication is highly regulated and primarily controlled at the step of initiation. In bacteria, the replication initiator DnaA and the origin of replication oriC are the primary targets of regulation. Perturbations that increase or decrease repl