Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Janet K. Parrish"'
Autor:
Lays M. Sobral, Hannah M. Hicks, Janet K. Parrish, Tyler S. McCann, Joseph Hsieh, Andrew Goodspeed, James C. Costello, Joshua C. Black, Paul Jedlicka
Publikováno v:
Molecular Oncology, Vol 14, Iss 10, Pp 2471-2486 (2020)
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and young adults. RMS exists as two major disease subtypes, oncofusion‐negative RMS (FN‐RMS) and oncofusion‐positive RMS (FP‐RMS). FP‐RMS is characterized by recurren
Externí odkaz:
https://doaj.org/article/220840bd9fd744769639420b420d91fe
Autor:
Joseph Hsieh, James C. Costello, Paul Jedlicka, Lays M. Sobral, Chelsea Self, Marybeth Sechler, Andrew Goodspeed, Janet K. Parrish, Kenneth L. Jones, Tyler S. McCann
Publikováno v:
Oncotarget
Ewing sarcoma is an aggressive malignant neoplasm with high propensity for metastasis and poor clinical outcomes. The EWS/Fli1 oncofusion is the disease driver in > 90% of cases, but presents a difficult therapeutic target. Moreover, EWS/Fli1 plays a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6caf11a33b941f0c419e1904cd8f11
https://doi.org/10.18632/oncotarget.27737
https://doi.org/10.18632/oncotarget.27737
Autor:
Tyler S. McCann, Joseph Hsieh, James C. Costello, Paul Jedlicka, Andrew Goodspeed, Lays M. Sobral, Janet K. Parrish, Hannah M. Hicks, Joshua C. Black
Publikováno v:
Molecular Oncology, Vol 14, Iss 10, Pp 2471-2486 (2020)
Molecular Oncology
Molecular Oncology
Fusion‐positive rhabdomyosarcoma (FP‐RMS) is an aggressive pediatric cancer. The chromatin factor KDM3A and the downstream transcription factor Ets1 comprise a new epigenetic axis that works together with, as well as independently of, the driver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3674546719b87787a0cc9743b1868ee7
https://doi.org/10.1002/1878-0261.12769
https://doi.org/10.1002/1878-0261.12769
Autor:
Janet K. Parrish, Kenneth L. Jones, Tyler S. McCann, Paul Jedlicka, Joshua C. Black, Marybeth Sechler, Lays M. Sobral
Publikováno v:
Genes & Cancer
Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy of childhood. RMS exists as two major disease subtypes, with oncofusion-positive RMS (FP-RMS) typically carrying a worse prognosis than oncofusion-negative RMS (FN-RMS), in part due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c88b0181c4c1b6dcfa65ea6bad98101
https://pubmed.ncbi.nlm.nih.gov/32577157
https://pubmed.ncbi.nlm.nih.gov/32577157
Autor:
Tyler S. McCann, Paul Jedlicka, Kenneth L. Jones, Janet K. Parrish, Aik Choon Tan, Marybeth Sechler, Lays M. Sobral, Wen Hua Ren
Publikováno v:
Oncotarget. 9:33110-33123
Ewing Sarcoma is an aggressive malignant neoplasm affecting children and young adults. Ewing Sarcoma is driven by transcription factor fusion oncoproteins, most commonly EWS/Fli1. While some patients can be cured with high-dose, multi-agent, chemothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52e508af4db8d3446fb76ca126c3f54
https://doi.org/10.18632/oncotarget.26011
https://doi.org/10.18632/oncotarget.26011
Publikováno v:
Oncogene
Ewing Sarcoma is the second most common solid pediatric malignant neoplasm of bone and soft tissue. Driven by EWS/Ets, or rarely variant, oncogenic fusions, Ewing Sarcoma is a biologically and clinically aggressive disease with a high propensity for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1f6f5e1ce14125ebb47ea1c8695b18
https://doi.org/10.1038/onc.2017.44
https://doi.org/10.1038/onc.2017.44
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178028 (2017)
PLoS ONE
PLoS ONE
Ewing Sarcoma is an aggressive, oncofusion-driven, malignant neoplasm of bone and soft tissue affecting predominantly children and young adults. Seeking to identify potential novel therapeutic targets/agents for this disease, our previous studies unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23676497f2dab668f30edcfc7dc50517
http://europepmc.org/articles/PMC5436853?pdf=render
http://europepmc.org/articles/PMC5436853?pdf=render
Publikováno v:
ESMO Open. 3:A166
Introduction Rhabdomyosarcoma (RMS) and Osteosarcoma (OS) are the most common primary malignant tumours of soft tissue and bones, respectively, affecting children, adolescents and young adults. RMS can be divided into two major histopathological and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c18f30aa201677d9f8cf23e11bd19ecd
https://doi.org/10.1136/esmoopen-2018-eacr25.397
https://doi.org/10.1136/esmoopen-2018-eacr25.397
Publikováno v:
Oncogene. 34(2)
Ewing Sarcoma is a biologically aggressive bone and soft tissue malignancy affecting children and young adults. Ewing Sarcoma pathogenesis is driven by EWS/Ets fusion oncoproteins, of which EWS/Fli1 is the most common. We have previously shown that m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da7494f6d07e5104f7f68488147628c
https://pubmed.ncbi.nlm.nih.gov/24362521
https://pubmed.ncbi.nlm.nih.gov/24362521
Publikováno v:
Cancer Research. 76:A22-A22
This study aims to explore the roles and mechanisms of new candidates for therapeutic targeting in Ewing Sarcoma. Ewing Sarcoma is an aggressive pediatric malignancy of the bone and soft tissue, driven by EWS/Ets oncogenic fusions and characterized b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc977ea3596e5f72b478ad625bc43700
https://doi.org/10.1158/1538-7445.pedca15-a22
https://doi.org/10.1158/1538-7445.pedca15-a22