Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Janet K. Coller"'
Publikováno v:
Cancers, Vol 15, Iss 17, p 4301 (2023)
Adverse effects are a common consequence of cytotoxic cancer treatments. Over the last two decades there have been significant advances in exploring the relationship between the gut microbiome and these adverse effects. Changes in the gut microbiome
Externí odkaz:
https://doaj.org/article/307dfc29863d410988d5c5053e50b7ae
Autor:
Elise E. Crame, Joanne M. Bowen, Kate R. Secombe, Janet K. Coller, Maxime François, Wayne Leifert, Hannah R. Wardill
Publikováno v:
Inflammatory Intestinal Diseases, Pp 1-11 (2021)
Introduction: Toll-like receptor 4 (TLR4) is a highly conserved immunosurveillance protein of innate immunity, displaying well-established roles in homeostasis and intestinal inflammation. Current evidence shows complex relationships between TLR4 act
Externí odkaz:
https://doaj.org/article/86b94b6a3d21484687c97bb9aae4b19d
Autor:
Kate R. Secombe BHSc (Hons), Ysabella Z. A. Van Sebille PhD, Bronwen J. Mayo PhD, Janet K. Coller PhD, Rachel J. Gibson PhD, Joanne M. Bowen PhD
Publikováno v:
Integrative Cancer Therapies, Vol 19 (2020)
Small molecule receptor tyrosine kinase inhibitors (SM-TKIs) are among a group of targeted cancer therapies, intended to be more specific to cancer cells compared with treatments, such as chemotherapy, hence reducing adverse events. Unfortunately, ma
Externí odkaz:
https://doaj.org/article/7ec33cd2800a42e8828cc2fbaafe97e5
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
BackgroundInnate immunity contributes to acute rejection after kidney transplantation. Genetic polymorphisms affecting innate immunity may therefore influence patients’ risk of rejection. IL2 -330T > G, IL10 -1082G > A, -819C > T, and -592C > A, an
Externí odkaz:
https://doaj.org/article/09f5dab800634c7eb84f26678c393ba0
Autor:
Janet K. Coller, Jonathan Tuke, Taylor J. Wain, Emily Quinn, Lea Steele, Maria Abreu, Kristina Aenlle, Nancy Klimas, Kimberly Sullivan
Publikováno v:
Brain Sciences, Vol 11, Iss 11, p 1410 (2021)
Gulf War illness (GWI) encompasses a constellation of persistent debilitating symptoms associated with significant changes in central nervous system (CNS) and immune functioning. Currently, there is no validated biomarker for GWI risk susceptibility.
Externí odkaz:
https://doaj.org/article/0e53061fb24c48729477aea90d16f70f
Autor:
Lea Steele, Nancy Klimas, Maxine Krengel, Emily Quinn, Rosemary Toomey, Deborah Little, Maria Abreu, Kristina Aenlle, Ronald Killiany, Bang-Bon Koo, Patricia Janulewicz, Timothy Heeren, Allison N. Clark, Joy Ajama, Joanna Cirillo, Gerardo Buentello, Vanesa Lerma, Janet K. Coller, Kimberly Sullivan
Publikováno v:
Brain Sciences, Vol 11, Iss 9, p 1132 (2021)
The Boston University-based Gulf War Illness Consortium (GWIC) is a multidisciplinary initiative developed to provide detailed understanding of brain and immune alterations that underlie Gulf War illness (GWI), the persistent multisymptom disorder as
Externí odkaz:
https://doaj.org/article/8aa06c05e752408ca15e790b15f4563f
Autor:
Samantha K. Korver, Joanne M. Bowen, Rachel J. Gibson, Imogen A. Ball, Kate R. Secombe, Taylor J. Wain, Richard M. Logan, Jonathan Tuke, Kelly R. Mead, Alison M. Richards, Christos S. Karapetis, Dorothy M. Keefe, Janet K. Coller
Publikováno v:
Cancer Chemotherapy and Pharmacology. 91:507-521
Purpose Adverse effects following fluoropyrimidine-based chemotherapy regimens are common. However, there are no current accepted diagnostic markers for prediction prior to treatment, and the underlying mechanisms remain unclear. This study aimed to
Autor:
Janine S. Y. Tam, Elise E. Crame, Aurelia S. Elz, Janet K. Coller, Anthony Wignall, Clive A. Prestidge, Joanne M. Bowen
Publikováno v:
Cancer Chemotherapy and Pharmacology. 90:267-278
Introduction Gastrointestinal mucositis (GIM) is a side effect of high-dose irinotecan (CPT-11), causing debilitating symptoms that are often poorly managed. The role of TLR4 in the development of GIM has been clearly demonstrated. We, therefore, aim
Publikováno v:
Inflammation. 46:103-114
Activation of toll-like receptor 4 (TLR4) has been shown to be a major influence on the inflammatory signalling pathways in intestinal mucositis (IM), as demonstrated by TLR4 knock-out mice. Pharmacological TLR4 inhibition has thus been postulated as
Autor:
Rachel J. Gibson, Elise E. Crame, Janine S. Y. Tam, Kate R. Secombe, Janet K. Coller, Hannah R. Wardill, Joanne M. Bowen
Publikováno v:
Cancer Chemotherapy and Pharmacology. 89:275-281
PURPOSE Irinotecan can cause high levels of diarrhea caused by toxic injury to the gastrointestinal microenvironment. Toll-like receptor 4 (TLR4) and the gut microbiome have previously been implicated in gastrointestinal toxicity and diarrhea; howeve