Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Janet J. Diliberto"'
Publikováno v:
Toxicological Sciences. 164:218-228
The effects of body fat mass on the elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was examined in mice. When male C57BL/6J mice are fed a high-fat, simple carbohydrate diet (HFD) for 13 weeks, they develop an obese phenotype. In contrast,
Autor:
David M. DeMarini, Janet J. Diliberto, Larry D. Claxton, Daniel H. Kusnierz, Valerie Marshall, Adam Swank, Sarah H. Warren, Thomas J. Hughes
Publikováno v:
Chemosphere. 120:690-696
U.S. Environmental Protection Agency (US EPA) Regional Applied Research Effort (RARE) projects address the effects of environmental pollutants in a particular region on the health of the population in that region. This report is part of a RARE projec
Publikováno v:
Environmental Science & Technology. 46:13494-13503
The metabolism of α- and γ-hexabromocyclododecane (HBCD) was investigated in adult C57BL/6 female mice. α- or γ-[(14)C]HBCD (3 mg/kg bw) was orally administered with subsequent urine and feces collection for 4 consecutive days; a separate group o
Publikováno v:
Toxicological Sciences. 123:256-263
Hexabromocyclododecane (HBCD) is a mixture of three stereoisomers alpha (α), beta (β), and gamma (γ). γ-HBCD dominates the mixture (∼70%), and despite α-HBCD's minor contribution to global HBCD production and usage (∼10%), it is the dominant
Publikováno v:
Toxicological Sciences. 121:234-244
Alpha-hexabromocyclododecane (α-HBCD) is an emerging persistent organic pollutant present in the hexabromocyclododecane (HBCD) commercial mixture. HBCD is used as an additive flame retardant in a wide variety of household consumer products. Three ma
Autor:
David T. Szabo, Vicki M. Richardson, Linda S. Birnbaum, David G. Ross, Prasada Rao S. Kodavanti, Janet J. Diliberto
Publikováno v:
Toxicological Sciences. 107:27-39
Previous studies demonstrated that perinatal exposure to polybrominated diphenyl ethers (PBDEs), a major class of brominated flame retardants, may affect thyroid hormone (TH) concentrations by inducing hepatic uridinediphosphate-glucoronosyltransfera
Autor:
Vicki M. Richardson, David J. Smith, Janet J. Diliberto, Linda S. Birnbaum, Heather M. Stapleton, Heldur Hakk, Janice K. Huwe
Publikováno v:
Environmental Science & Technology. 42:2694-2700
Household dust has been implicated as a major source of polybrominated diphenyl ether (PBDE) exposure in humans. This finding has important implications for young children, who tend to ingest more dust than adults and may be more susceptible to some
Publikováno v:
Toxicological Sciences. 90:309-316
Despite its minor contribution to global polybrominated diphenyl ether (PBDE) production and usage, 2,2',4,4'-tetrabromodiphenyl ether (BDE 47) is the dominant congener found in most biotic samples in North America. The majority of public health conc
Autor:
Janet J. Diliberto, Robert I. Krieger, Hugh A. Barton, Karl Baetcke, Timothy P. Pastoor, Jeffrey H. Driver, Charles Timchalk, Charles Hastings, Bernhard Stahl, Janice E. Chambers, Nancy G. Doerrer, Seshadri Iyengar
Publikováno v:
Critical Reviews in Toxicology. 36:9-35
A proposal has been developed by the Agricultural Chemical Safety Assessment (ACSA) Technical Committee of the ILSI Health and Environmental Sciences Institute (HESI) for an improved approach to assessing the safety of crop protection chemicals. The
Publikováno v:
Toxicological Sciences. 84:225-231
Dioxins have been shown to bind and induce rodent CYP1A2, producing a dose-dependent hepatic sequestration in vivo. The induction of CYP1A2 activity has been used as a noninvasive biomarker for human exposure to dioxins; while there is a consistent r