Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Janet J, Maguire"'
Autor:
Fiona A. Chapman, Vanessa Melville, Emily Godden, Beth Morrison, Lorraine Bruce, Janet J. Maguire, Anthony P. Davenport, David E. Newby, Neeraj Dhaun
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Chronic kidney disease (CKD) affects ~10% of the population and cardiovascular disease is its commonest complication. Despite treatment, patient outcomes remain poor and newer therapies are urgently needed. Here, we investigated the systemic
Externí odkaz:
https://doaj.org/article/a8c1638edaca4bb18b19ebe2771439f4
Autor:
Thomas L. Williams, Peter Nwokoye, Rhoda E. Kuc, Kieran Smith, Anna L. Paterson, Kieren Allinson, Janet J. Maguire, Anthony P. Davenport
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Glioblastoma multiforme (GBM) is one of the most common and lethal forms of brain cancer, carrying a very poor prognosis (median survival of ~15 months post-diagnosis). Treatment typically involves invasive surgical resection of the tumour mass, foll
Externí odkaz:
https://doaj.org/article/427b6cfec96b41d09449576a64cb7fe6
Autor:
Thomas L. Williams, Duuamene Nyimanu, Rhoda E. Kuc, Richard Foster, Robert C. Glen, Janet J. Maguire, Anthony P. Davenport
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Pulmonary arterial hypertension (PAH) is characterised by endothelial dysfunction and pathological vascular remodelling, resulting in the occlusion of pulmonary arteries and arterioles, right ventricular hypertrophy, and eventually fata
Externí odkaz:
https://doaj.org/article/96d17a331f9240c6a1914d929b042de1
Autor:
Thomas L. Williams, Robyn G. C. Macrae, Rhoda E. Kuc, Alastair J. H. Brown, Janet J. Maguire, Anthony P. Davenport
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionThe apelin receptor binds two distinct endogenous peptides, apelin and ELA, which act in an autocrine/paracrine manner to regulate the human cardiovascular system. As a class A GPCR, targeting the apelin receptor is an attractive therapeu
Externí odkaz:
https://doaj.org/article/bf7d26bd0e894f9489e39b0a341afeaa
Autor:
Thomas L. Williams, Gregory Strachan, Robyn G. C. Macrae, Rhoda E. Kuc, Duuamene Nyimanu, Anna L. Paterson, Sanjay Sinha, Janet J. Maguire, Anthony P. Davenport
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract ACE2 is a membrane protein that regulates the cardiovascular system. Additionally, ACE2 acts as a receptor for host cell infection by human coronaviruses, including SARS-CoV-2 that emerged as the cause of the on-going COVID-19 pandemic and h
Externí odkaz:
https://doaj.org/article/4c7d25172fb64bbb8805217fa8c59d59
Autor:
Thomas L. Williams, Maria T. Colzani, Robyn G. C. Macrae, Emma L. Robinson, Stuart Bloor, Edward J. D. Greenwood, Jun Ru Zhan, Gregory Strachan, Rhoda E. Kuc, Duuamene Nyimanu, Janet J. Maguire, Paul J. Lehner, Sanjay Sinha, Anthony P. Davenport
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)
Williams et al. confirm that human embryonic stem cell-derived cardiomyocytes express the protein machinery critical for SARS-CoV-2 infection and are susceptible to SARS-CoV-2 spike protein pseudotyped virus infection. They further use this platform
Externí odkaz:
https://doaj.org/article/38772e0bff5a4477befd0ea1c3205005
Autor:
George R. Abraham, Duuamene Nyimanu, Rhoda E. Kuc, Janet J. Maguire, Anthony P. Davenport, Stephen P. Hoole
Publikováno v:
Journal of Interventional Cardiology, Vol 2022 (2022)
Objective. Coronary microvascular dysfunction (CMD) can complicate successful percutaneous coronary intervention (PCI). The potent endogenous vasoconstrictor peptide Endothelin-1 (ET-1) may be an important mediator. To investigate the mechanism, we s
Externí odkaz:
https://doaj.org/article/c6aa952e63c74751af16c0fd94c49375
Autor:
Cai Read, Duuamene Nyimanu, Peiran Yang, Rhoda E. Kuc, Thomas L. Williams, Christopher M. Fitzpatrick, Richard Foster, Robert C. Glen, Janet J. Maguire, Anthony P. Davenport
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Signaling through the apelin receptor is beneficial for a number of diseases including pulmonary arterial hypertension. The endogenous small peptides, apelin and elabela/toddler, are downregulated in pulmonary arterial hypertension but are not suitab
Externí odkaz:
https://doaj.org/article/2d0660c081eb47399d2ca55e2ed4196f
Autor:
Thomas L. Williams, Robert R. Ruffolo, Eliot H. Ohlstein, Janet J. Maguire, Théophile Godfraind, Anthony P. Davenport, Pedro D'Orléans-Juste, George R. Abraham
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Endothelin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Endothelin Receptors [24]) are activated by the endogenous 21 amino-acid peptides endothelins 1-3 (endothelin-1, endothelin-2 and endothelin-3).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9be32cdbaa201b0445cd4a3e682a7cec
https://doi.org/10.2218/gtopdb/f21/2023.1
https://doi.org/10.2218/gtopdb/f21/2023.1
Autor:
Hubert Vaudry, Stefany D. Primeaux, Janet J. Maguire, Jérôme Leprince, Dan Larhammar, Riccarda Granata, Shoji Fukusumi, Stephen M. Foord, Anthony P. Davenport, Myrna Carlebur, Tom I. Bonner, Didier Bagnol
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
The human gene encoding the QRFP receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee on the QRFP receptor [19]; QRFPR, formerly known as the Peptide P518 receptor), previously designated as an orphan GPCR receptor was identified in 2001 by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90babe7f99f294fd0e8b58e701934011
https://doi.org/10.2218/gtopdb/f54/2023.1
https://doi.org/10.2218/gtopdb/f54/2023.1