Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Janet Holden"'
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181131 (2017)
Acting through a complex signalling network, DNA lesions trigger a range of cellular responses including DNA repair, cell cycle arrest, altered gene expression and cell death, which help to limit the mutagenic effects of such DNA damage. RNA processi
Externí odkaz:
https://doaj.org/article/62ae1f4fa9294b5384d67890ffb204a4
Autor:
Serena Viappiani, Yu Zhu, Christopher Power, Kristofor K. Ellestad, Janet Holden, Ferdinand Maingat, Pornpun Vivithanaporn, Claudia Silva
Publikováno v:
The Journal of Immunology. 184:1566-1574
Lentivirus infections including HIV and feline immunodeficiency virus (FIV) cause neurovirulence, which is largely mediated by innate immunity. To investigate the interactions between neurovirulence and repeated conditioning by innate immune activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856b2eba26b1e1b3a1bb424be91157bc
https://doi.org/10.4049/jimmunol.0902575
https://doi.org/10.4049/jimmunol.0902575
Autor:
Éric A. Cohen, Jack H. Jhamandas, Janet Holden, Peter Dickie, Chris Power, Gareth Jones, Kim H. Harris, Nicola Barsby
Publikováno v:
The Journal of Neuroscience. 27:3703-3711
Despite the introduction of highly active antiretroviral therapy, dementia caused by human immunodeficiency virus-1 (HIV-1) infection remains a devastating and common neurological disorder. Although the mechanisms governing neurodegeneration during H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320d0be69525eacc833d171b207dc0ca
https://doi.org/10.1523/jneurosci.5522-06.2007
https://doi.org/10.1523/jneurosci.5522-06.2007
Autor:
Alicia Klatt, Shigeki Tsutsui, Christopher Power, Pamela H. Correll, Janet Holden, Eileen S. Lee, Parisa Kalantari, Andrew J. Henderson
Publikováno v:
Scopus-Elsevier
Activation of macrophages and microglia cells after HIV-1 infection and their production of inflammatory mediators contribute to HIV-associated CNS diseases. The mechanisms that initiate and maintain inflammation after HIV-1 infection in the brain ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2aad95a213d8bfef7a000b578f9dfd
https://doi.org/10.4049/jimmunol.173.11.6864
https://doi.org/10.4049/jimmunol.173.11.6864
Autor:
Justin C. McArthur, Scot D. Henry, Claudia Silva, M. John Gill, Guido van Marle, Janet Holden, Sean B. Rourke, Tiona R. Todoruk, Andrea Sullivan, Christopher Power
Publikováno v:
Virology. 329(2):302-318
HIV-1 Nef is expressed in astrocytes, but a contribution to neuropathogenesis and the development of HIV-associated dementia (HAD) remains uncertain. To determine the neuropathogenic actions of the HIV-1 Nef protein, the brain-derived (YU-2) and bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b4a41dd45ab25624c9924f18282cab
Autor:
Janet Holden, G. Angus McQuibban, Christopher Power, Georgina S. Butler, Christopher M. Overall, James B. Johnston, Kunyan Zhang, Ian Clark-Lewis, Claudia Silva
Publikováno v:
Nature Neuroscience. 6:1064-1071
The mechanisms of neurodegeneration that result in human immunodeficiency virus (HIV) type 1 dementia have not yet been identified. Here, we report that HIV-infected macrophages secrete the zymogen matrix metalloproteinase-2 (MMP-2), which is activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcb01fb1d105fcc3d411619bd3ab2e0
https://doi.org/10.1038/nn1127
https://doi.org/10.1038/nn1127
Publikováno v:
Chest. 122:806-811
Study objectives: To compare the effect of 4 weeks of treatment with fluticasone propionate (FP), 100 g bid, delivered either via the Diskhaler (GlaxoSmithKline; Middlesex, UK) or a hydrofluoroalkane (HFA)-134a pressurized metered-dose inhaler (pMDI)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2bc648743b9c368556e62c31f731164
https://doi.org/10.1378/chest.122.3.806
https://doi.org/10.1378/chest.122.3.806
Publikováno v:
Journal of Clinical Nursing. 11:140-148
1. Nurses striving to give holistic care to provide quality care for their patients, need to recognize the importance of caring for patients' families. 2. A detailed review of the literature examining the relationships between nurses and intensive ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759d18b9d5e8f818d51d2c7069672a94
https://doi.org/10.1046/j.1365-2702.2002.00581.x
https://doi.org/10.1046/j.1365-2702.2002.00581.x
Autor:
Claudia Silva, Janet Holden, Kennith G. Warren, Christopher Power, Guido C. Gonzalez, Luanne M. Metz, James B. Johnston
Publikováno v:
Annals of Neurology. 49:650-658
The nucleoside adenosine has been shown to control the production of proinflammatory molecules through its actions on cell surface purine receptors. Previously, we have reported that the adenosine A1 receptor (A1AR) regulates tumor necrosis factor-al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e31a0e275c21a6bcdb6f660d6ddb53ea
https://doi.org/10.1002/ana.1007
https://doi.org/10.1002/ana.1007
Autor:
Janet Holden, Kenneth G. Warren, Arthur W. Clark, Christopher Power, Claudia Silva, James B. Johnston
Publikováno v:
Annals of Neurology. 50:434-442
Human endogenous retroviruses (HERVs) have been implicated as causative agents in diseases characterized by inflammation and macrophage activation, such as multiple sclerosis. Because monocyte activation and differentiation influence retroviral trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200a1e63b0abbc7ef35f2427c355c8cc
https://doi.org/10.1002/ana.1131
https://doi.org/10.1002/ana.1131