Výsledky vyhledávání - "Janet Hinman"

Successful utilization of lyophilized lipoprotein(a) as a biological reagent

Autor: Angelo M. Scanu, Celina Edelstein, Ditta Pfaffinger, Janet Hinman

Publikováno v: Lipids. 39:589-593

Lipoprotein(a) [Lp(a)] represents a class of lipoprotein particles having as a protein moiety apoB-100 linked by a single disulfide bond to apolipoprotein(a) [apo(a)], a multikringle structure with a high degree of homology with plasminogen. A recogn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b2a4f77b3c5e14c54166baedb52d68
https://doi.org/10.1007/s11745-004-1268-5

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Properties of Human Free Apolipoprotein(a) and Lipoprotein(a) after Either Freezing or Lyophilization in the Presence and Absence of Cryopreservatives

Autor: Celina Edelstein, Santica M. Marcovina, Janet Hinman, Angelo M. Scanu

Publikováno v: Analytical Biochemistry. 288:201-208

Apolipoprotein(a), apo(a), the specific multikringle glycoprotein constituent of lipoprotein(a), Lp(a), occurs in the plasma mostly bound to apoB100-containing lipoproteins but also in a free form. Often the properties of these products are determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7372c7a6e9cf65eafee3e3cd1972b75e
https://doi.org/10.1006/abio.2000.4904

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A single point mutation (Trp72 → Arg) in human apo(a) kringle 4-37 associated with a lysine binding defect in Lp(a)

Autor: Ditta Pfaffinger, Angelo M. Scanu, Janet Hinman, John C. Lee

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1227:41-45

Human lipoprotein(a) or Lp(a) binds, like plasminogen, to lysine Sepharose. However, contrary to plasminogen in which kringles 1 and 4 have been implicated, the binding site or sites on apo(a), the specific glycoprotein of Lp(a), have not been determ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fe1fb417ded66fcc85e9e3998f1aad
https://doi.org/10.1016/0925-4439(94)90104-x

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Postprandial lipoprotein (a) response to a single meal containing either saturated or ω-3 polyunsaturated fatty acids in subjects with hypoalphalipoproteinemia

Autor: James D. Eisenbart, Bahaa Kasawa, Janet Hinman, Gunther M. Fless, Celina Edelstein, Michael D. Sitrin, Angelo M. Scanu

Publikováno v: Metabolism. 41:1361-1366

We have recently reported that the apolipoprotein (apo) B-100-apo(a) complex, the protein moiety of lipoprotein(a) [Lp(a)], has a high affinity for triglyceride(TG)-rich particles (TRP) and that this complex can affiliate with endogenous TG-rich lipo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfe018745b765f6a7fa74620dfc739f
https://doi.org/10.1016/0026-0495(92)90108-m

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Attenuation of immunologic reactivity of lipoprotein(a) by thiols and cysteine-containing compounds. Structural implications

Autor: Gunther M. Fless, Kazuhiko Makino, James D. Eisenbart, Ditta Pfaffinger, Angelo M. Scanu, Janet Hinman

Publikováno v: Arteriosclerosis and Thrombosis: A Journal of Vascular Biology. 12:424-429

Samples of human plasma having lipoprotein(a) (Lp[a]) protein levels between 5 and 15 mg/dl and a single apolipoprotein(a) (apo[a]) isoform were incubated in vitro at pH 7.7 with various concentrations (1-20 mM) of N-acetylcysteine, homocysteine, 2-m

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https://doi.org/10.1161/01.atv.12.4.424

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Lysine-phosphatidylcholine adducts in kringle V impart unique immunological and potential pro-inflammatory properties to human apolipoprotein(a)

Autor: Claes Bergmark, Elizabeth C. Miller, Gregory M. Lipkind, Janet Hinman, Celina Edelstein, Angelo M. Scanu, Godfrey S. Getz, Sotirios Tsimikas, Ditta Pfaffinger, Joseph L. Witztum

Publikováno v: The Journal of biological chemistry. 278(52)

Lipoprotein(a), Lp(a), an athero-thrombotic risk factor, reacts with EO6, a natural monoclonal autoantibody that recognizes the phophorylcholine (PC) group of oxidized phosphatidylcholine (oxPtdPC) either as a lipid or linked by a Schiff base to lysi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3458771071cd1185b7ded1086c1b0f08
https://pubmed.ncbi.nlm.nih.gov/14557258

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Issues concerning the monitoring of statin therapy in hypercholesterolemic subjects with high plasma lipoprotein(a) levels

Autor: Janet Hinman, Angelo M. Scanu

Publikováno v: Lipids. 37(5)

Most studies on the topic have shown that statin therapy decreases plasma LDL levels but not those of lipoprotein(a) [Lp(a)]. This specificity of action, although previously noted, has not been systematically investigated. In the current study we app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d4581563faabffa0592bfed753fdc8
https://pubmed.ncbi.nlm.nih.gov/12056584

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Changes in plasma triglyceride levels shift lipoprotein(a) density in parallel with that of LDL independently of apolipoprotein(a) size

Autor: Janet Hinman, Kei Nakajima, Ditta Pfaffinger, Angelo M. Scanu, Celina Edelstein

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 21(7)

Abstract —Lipoprotein(a) [Lp(a)] represents a class of low density lipoprotein (LDL) particles that have as a protein moiety apolipoprotein B-100–linked covalently to a single molecule of apolipoprotein(a) [apo(a)], a specific multikringle protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ead4c23aea39b563e150da5b688276b
https://pubmed.ncbi.nlm.nih.gov/11451758

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