Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Janet Hawkins"'
Autor:
Staffan Karlsson, Helen Benson, Calum Cook, Gordon Currie, Jerome Dubiez, Hans Emtenäs, Janet Hawkins, Rebecca Meadows, Peter D. Smith, Jeffrey Varnes
Publikováno v:
Organic Process Research & Development. 26:601-615
Autor:
Tieguang Yao, Liangwei Wu, Craig S. Donald, Douglas Ferguson, Lei Wang, Andrew Pike, Jianyan Wang, Justin Cidado, Dedong Wu, Kurt Gordon Pike, Kumar Thakur, Chungang Gu, Calum Cook, James Horstick, Tyler Grebe, Theresa Proia, Darren Stead, Alexander Hird, Michelle Lamb, Wenlin Shao, Nichole O'Connell, Yun Jiang, Sudhir M. Hande, Bin Yang, Janet Hawkins, Barlaam Bernard Christophe, Neil Sumner, Melissa Vasbinder, Andrew D. Ferguson, Jane E. Moore, Jeffrey G. Varnes, Bryan Roberts, Maryann San Martin, Lisa Drew, Ujjal Sarkar, Allan Dishington, Chris De Savi, Robert Casella, Steve C. Glossop, Jane L. Holmes, Thomas M. McGuire
Publikováno v:
Journal of Medicinal Chemistry. 63:15564-15590
A CDK9 inhibitor having short target engagement would enable a reduction of Mcl-1 activity, resulting in apoptosis in cancer cells dependent on Mcl-1 for survival. We report the optimization of a series of amidopyridines (from compound 2), focusing o
Autor:
Lei Wang, Allan Dishington, Jane E. Moore, Kurt Gordon Pike, Wenlin Shao, Andrew Lister, Anil Patel, Lorraine A. Hassall, Sudhir M. Hande, Jane L. Holmes, Douglas Ferguson, Thomas M. McGuire, Jeffrey G. Varnes, Lin Xue, Chungang Gu, Tieguang Yao, Barlaam Bernard Christophe, Lisa Drew, Janet Hawkins, Liangwei Wu, Chris De Savi, Melissa Vasbinder, Andrew D. Ferguson, Darren Stead, Ujjal Sarkar, Michelle Lamb, Nichole O'Connell, Bin Yang, Alexander Hird
Publikováno v:
Journal of medicinal chemistry. 64(20)
Optimization of a series of azabenzimidazoles identified from screening hit 2 and the information gained from a co-crystal structure of the azabenzimidazole-based lead 6 bound to CDK9 led to the discovery of azaindoles as highly potent and selective
Publikováno v:
Physical & Occupational Therapy In Geriatrics. 37:32-49
Aims: This retrospective study explored how mechanisms and elements of the Intentional Relationship Model may support volition and engagement in occupation for individuals living with demen...
Autor:
Anil Patel, Rebecca E. Meadows, Kurt Gordon Pike, Jane E. Moore, Turner Paul, Darren Stead, Barlaam Bernard Christophe, Andrew Stark, Jemma Clark, Janet Hawkins, Bin Yang, Bryan Roberts, Craig S. Donald, Gemma Davison, Esther Moore, Chris De Savi, Tyler Grebe, Calum Cook, Melissa Vasbinder, Simon C. C. Lucas, Andrew Lister, Jeffrey G. Varnes, Kumar Thakur, Sudhir M. Hande, Jane L. Holmes, Thomas M. McGuire, Alexander Hird, Allan Dishington
Publikováno v:
Tetrahedron Letters. 57:4718-4722
As part of a medicinal chemistry program, we adapted known synthetic methods for the late-stage diversification of 2,4-substituted 7-azaindoles. The strengths and weaknesses of these strategies are discussed. In the course of this work, three optimiz
Autor:
Laksmaiah Gingipalli, Jane E. Moore, Rosemary A. Croft, Barlaam Bernard Christophe, Janet Hawkins, Hai-Jun Zhang, Tao Wang, Anil Patel, Lynsie Almeida, Xiaolan Zheng, Kurt Gordon Pike, Timothy Pontz, Allan Dishington, Stephanos Ioannidis, Xiaoyun Wu, Jeffrey W. Johannes, Lorraine A. Hassall, Jane L. Holmes, Thomas M. McGuire
Publikováno v:
Synthesis. 48:1226-1234
Examples of hydroxymethylated analogues of heteroaryl cores such as quinazolin-4-ones, isoquinolin-1(2H)-ones, pyrido[3,4-d]pyrimidin-4(3H)-ones, chromen-4-ones and pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones are sparse or non-existent in the scientific
Publikováno v:
Tetrahedron Letters. 55:6734-6737
A synthetic strategy for the synthesis of a library of 4- N -benzylamino-2- N -phenyl-pyridines is herein described. The approach involves a Pd-assisted cross-coupling of a 4-chloro- N -phenylpyridin-2-amine intermediate with a range of benzylamines.
Publikováno v:
ChemInform. 47
The first regioselective, mild bromination of thieno[2,3-b]pyridine is described herein. The reaction proceeds with selectivity toward the 4-position (87% isolated yield). Subsequent cross-coupling reactions proceed in excellent yields and demonstrat
Autor:
Gary Fairley, Clare Lane, Phillippa Dudley, Jason Grant Kettle, Janet Hawkins, Shaun M. Fillery, Helen Plant, Simon J. Brown, Paul Faulder, Claire Crafter, Jennifer H. Pink, Hannah Greenwood, Martin Pass, Sabina Cosulich, Barry R. Davies, Keith M. Johnson, Michael James
Publikováno v:
Journal of Medicinal Chemistry. 55:1261-1273
Wide-ranging exploration of potential replacements for a quinoline-based inhibitor of activation of AKT kinase led to number of alternative, novel scaffolds with potentially improved potency and physicochemical properties. Examples showed predictable
Publikováno v:
The Journal of organic chemistry. 80(24)
The first regioselective, mild bromination of thieno[2,3-b]pyridine is described herein. The reaction proceeds with selectivity toward the 4-position (87% isolated yield). Subsequent cross-coupling reactions proceed in excellent yields and demonstrat