Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Janet Greeson"'
Publikováno v:
Molecules, Vol 14, Iss 9, Pp 3392-3410 (2009)
Elevated serum glucocorticoid levels contribute to the progression of many diseases, including depression, Alzheimer’s disease, hypertension, and acquired immunodeficiency syndrome. Here we show that the benzamide derivative N-[2-(4-cyclopropanecar
Externí odkaz:
https://doaj.org/article/3b1f9e91a1b14eb3bdc1147d77c60cc7
Autor:
Gábor Szabó, A.I. Hashim, I. Giscos-Douriez, Wenguo Yao, I. Dinca, Laurent Lecanu, Ferenc Erdélyi, Janet Greeson, Stefano Vicini, Vassilios Papadopoulos, Althea McCourty
Publikováno v:
Neuroscience. 183:251-264
In this study, we explored the capacity of the naturally occurring compound solasodine to promote neurogenesis in vitro and in vivo. Mouse embryonic teratocarcinoma P19 cells exposed to solasodine for 2 days followed by a 5-day washout differentiated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d258f21e230417ac429c1122116e1a1f
https://doi.org/10.1016/j.neuroscience.2011.03.042
https://doi.org/10.1016/j.neuroscience.2011.03.042
Autor:
Vassilios Papadopoulos, Althea McCourty, Laurent Lecanu, Janet Greeson, Laurent Tillement, Georges Rammouz, Wenguo Yao
Publikováno v:
Scopus-Elsevier
We report herein the synthesis and biological evaluation of dimethyl-carbamic acid 2,3-bis-dimethylcarbamoyloxy- 6-(4-ethyl-piperazine-1-carbonyl)-phenyl ester (SP-04), a new drug candidate that is designed to offer a multi-target therapeutic neuropr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28769458c73b0a3abbb18cf8ac77a3ad
https://doi.org/10.2174/1573406411006030123
https://doi.org/10.2174/1573406411006030123
Autor:
Vassilios Papadopoulos, Jean Paul Tillement, Laurent Tillement, Janet Greeson, Laurent Lecanu, Georges Rammouz
Publikováno v:
Expert Opinion on Investigational Drugs. 18:265-276
In search of new drugs for Alzheimer's disease, we departed from the classic concepts and investigated the ability of normal and Alzheimer's disease brain to convert cholesterol to steroids, otherwise known as neurosteroids. We identified 22R-hydroxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0fbacdd019c5cd6580c66714d1ba4f
https://doi.org/10.1517/13543780902762827
https://doi.org/10.1517/13543780902762827
Publikováno v:
Steroids. 71:725-735
Abeta(1-42) has been shown to uncouple the mitochondrial respiratory chain and promote the opening of the membrane permeability transition (MPT) pore, leading to cell death. We have previously reported that the spirostenol derivative (22R, 25R)-20alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad3f15b78b6480ba9fd3094b98c0b04
https://doi.org/10.1016/j.steroids.2006.05.003
https://doi.org/10.1016/j.steroids.2006.05.003
Publikováno v:
Pharmacology. 76:19-33
Infusion of Fe2+, Aβ42, and buthionine-sulfoximine (FAB), but not Aβ42 alone or in combination with Fe2+, into the left cerebral ventricle of Long-Evans rats for 4 weeks induced memory impairment that was accompanied by increased hyperphosphorylate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a29e0bd1146f31da8f809256441a9a
https://doi.org/10.1159/000088929
https://doi.org/10.1159/000088929
Publikováno v:
Analytical Biochemistry. 324:123-130
A specific and sensitive methodology for the quantitative determination of hydroxysteroids dehydroepiandrosterone and pregnenolone and their main metabolites in human plasma is described. Hydroxysteroids were extracted using methanol and steroids wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7710b2d72cc90ba09e575ffcbae546
https://doi.org/10.1016/j.ab.2003.10.001
https://doi.org/10.1016/j.ab.2003.10.001
Publikováno v:
Journal of Neurochemistry. 83:1110-1119
22R-hydroxycholesterol, a steroid intermediate in the pathway of pregnenolone formation from cholesterol, was found at lower levels in Alzheimer's disease (AD) hippocampus and frontal cortex tissue specimens compared to age-matched controls. beta-Amy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4472bd57c46e6f7b8ab5582ccdaad308
https://doi.org/10.1046/j.1471-4159.2002.01202.x
https://doi.org/10.1046/j.1471-4159.2002.01202.x
Autor:
Cristian L. Achim, Laurent Lecanu, Eliezer Masliah, Ian P. Everall, Amol Shah, Janet Greeson, Vassilios Papadopoulos, Ginger R. Lucero, Gursharan Chana
Publikováno v:
Neurobehavioral HIV Medicine.
Amol Shah1, Gursharan Chana1,2, Ginger R Lucero1, Eliezer Masliah3, Cristian L Achim1, Laurent Lecanu4, Vassilios Papadopoulos4, Janet Greeson5, Ian P Everall1,21Department of Psychiatry, HIV Neurobehavioral Research Center, University of California,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04eb514d6be44ba4604c395707549094
https://www.dovepress.com/amelioration-of-caspase-37-activity-by-sp01-in-human-primary-neurons-e-peer-reviewed-article-NBHIV
https://www.dovepress.com/amelioration-of-caspase-37-activity-by-sp01-in-human-primary-neurons-e-peer-reviewed-article-NBHIV
Publikováno v:
Chemistrybiodiversity. 2(11)
Spirostenol steroids have been found to inhibit beta-amyloid-induced neurotoxicity. We have evaluated in parallel experimental and molecular-modeling studies the relative effectiveness of 17 (22R)-hydroxycholesterol derivatives in binding to the targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66971608b7eacd10be0d59991e88ca17
https://pubmed.ncbi.nlm.nih.gov/17191956
https://pubmed.ncbi.nlm.nih.gov/17191956