Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Janet F Partridge"'
Autor:
Brandon R Lowe, Rajesh K Yadav, Ryan A Henry, Patrick Schreiner, Atsushi Matsuda, Alfonso G Fernandez, David Finkelstein, Margaret Campbell, Satish Kallappagoudar, Carolyn M Jablonowski, Andrew J Andrews, Yasushi Hiraoka, Janet F Partridge
Publikováno v:
eLife, Vol 10 (2021)
Sequencing of cancer genomes has identified recurrent somatic mutations in histones, termed oncohistones, which are frequently poorly understood. Previously we showed that fission yeast expressing only the H3.3G34R mutant identified in aggressive ped
Externí odkaz:
https://doaj.org/article/1deea5202d2c4144a85ce645ef7c9d33
Autor:
Priya Mittal, Jacquelyn A. Myers, Raymond D. Carter, Sandi Radko-Juettner, Hayden A. Malone, Wojciech Rosikiewicz, Alexis N. Robertson, Zhexin Zhu, Ishwarya V. Narayanan, Baranda S. Hansen, Meadow Parrish, Natarajan V. Bhanu, Robert J. Mobley, Jerold E. Rehg, Beisi Xu, Yiannis Drosos, Shondra M. Pruett-Miller, Mats Ljungman, Benjamin A. Garcia, Gang Wu, Janet F. Partridge, Charles W. M. Roberts
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are mutated in nearly 25% of cancers. To gain insight into the mechanisms by which SWI/SNF mutations drive cancer, we contributed ten rhabdoid tumor (RT) cell lines muta
Externí odkaz:
https://doaj.org/article/fb1fbd9e73e346ad922fc3783cc2f771
Autor:
Rajesh K Yadav, Carolyn M Jablonowski, Alfonso G Fernandez, Brandon R Lowe, Ryan A Henry, David Finkelstein, Kevin J Barnum, Alison L Pidoux, Yin-Ming Kuo, Jie Huang, Matthew J O’Connell, Andrew J Andrews, Arzu Onar-Thomas, Robin C Allshire, Janet F Partridge
Publikováno v:
eLife, Vol 6 (2017)
Recurrent somatic mutations of H3F3A in aggressive pediatric high-grade gliomas generate K27M or G34R/V mutant histone H3.3. H3.3-G34R/V mutants are common in tumors with mutations in p53 and ATRX, an H3.3-specific chromatin remodeler. To gain insigh
Externí odkaz:
https://doaj.org/article/6f07b04184fd448199fb62c77f4d0ff3
Autor:
Lindsey A Bierle, Kira L Reich, Braden E Taylor, Eliot B Blatt, Sydney M Middleton, Shawnecca D Burke, Laura K Stultz, Pamela K Hanson, Janet F Partridge, Mary E Miller
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138085 (2015)
Careful regulation of the cell cycle is required for proper replication, cell division, and DNA repair. DNA damage--including that induced by many anticancer drugs--results in cell cycle delay or arrest, which can allow time for repair of DNA lesions
Externí odkaz:
https://doaj.org/article/f79088bc07c443a597adf5fec4200fed
H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.
Autor:
Klavs R Hansen, Idit Hazan, Sreenath Shanker, Stephen Watt, Janne Verhein-Hansen, Jürg Bähler, Robert A Martienssen, Janet F Partridge, Amikam Cohen, Geneviève Thon
Publikováno v:
PLoS Genetics, Vol 7, Iss 1, p e1001268 (2011)
Nucleosomes in heterochromatic regions bear histone modifications that distinguish them from euchromatic nucleosomes. Among those, histone H3 lysine 9 methylation (H3K9me) and hypoacetylation have been evolutionarily conserved and are found in both m
Externí odkaz:
https://doaj.org/article/a670cdb460fd4b668806fc392be4176a
Autor:
Sreenath Shanker, Godwin Job, Olivia L George, Kevin M Creamer, Alaa Shaban, Janet F Partridge
Publikováno v:
PLoS Genetics, Vol 6, Iss 10, p e1001174 (2010)
Formation of centromeric heterochromatin in fission yeast requires the combined action of chromatin modifying enzymes and small RNAs derived from centromeric transcripts. Positive feedback mechanisms that link the RNAi pathway and the Clr4/Suv39h1 hi
Externí odkaz:
https://doaj.org/article/b5dc82926482455ba31cbcc84257455b
Autor:
Araceli G Castillo, Barbara G Mellone, Janet F Partridge, William Richardson, Georgina L Hamilton, Robin C Allshire, Alison L Pidoux
Publikováno v:
PLoS Genetics, Vol 3, Iss 7, p e121 (2007)
The histone H3 variant CENP-A assembles into chromatin exclusively at centromeres. The process of CENP-A chromatin assembly is epigenetically regulated. Fission yeast centromeres are composed of a central kinetochore domain on which CENP-A chromatin
Externí odkaz:
https://doaj.org/article/2201ef58a3f241cab67fe5dd1c5c855f
Autor:
Zhexin Zhu, Xiaolong Chen, Ao Guo, Trishabelle Manzano, Patrick J. Walsh, Kendall M. Wills, Rebecca Halliburton, Sandi Radko-Juettner, Raymond D. Carter, Janet F. Partridge, Douglas R. Green, Jinghui Zhang, Charles W. M. Roberts
Publikováno v:
Nature. 618:180-187
Publikováno v:
Microorganisms, Vol 9, Iss 9, p 1977 (2021)
Telomeres play important roles in safeguarding the genome. The specialized repressive chromatin that assembles at telomeres and subtelomeric domains is key to this protective role. However, in many organisms, the repetitive nature of telomeric and su
Externí odkaz:
https://doaj.org/article/cfd4f6536e7445c4afbdedbdac16cb83
Autor:
Robert J. Mobley, Jacquelyn A. Myers, Kendall M. Wills, Hayden A. Malone, Trishabelle I. Manzano, Janet F. Partridge, Charles W. M. Roberts
Genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are mutated in >20% of cancers. SWI/SNF complexes exist in three distinct families that each contribute to regulation of transcription, although the functional interactions betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a260e2f85bdf6cb485a6642a86b268d
https://doi.org/10.1101/2022.08.07.503080
https://doi.org/10.1101/2022.08.07.503080