Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Janet E. McElhaney"'
Autor:
Chris P. Verschoor, Daniel W. Belsky, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, Janet E. McElhaney, George A. Kuchel
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-11 (2022)
Abstract Background Biological aging represents a loss of integrity and functionality of physiological systems over time. While associated with an enhanced risk of adverse outcomes such as hospitalization, disability and death following infection, it
Externí odkaz:
https://doaj.org/article/b31517b3e7594943be5d302e6a7cabc9
Autor:
Emilie Picard, Sarah Armstrong, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, George A. Kuchel, Janet E. McElhaney, Chris P. Verschoor
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background With increasing age, overall health declines while systemic levels of inflammatory mediators tend to increase. Although the underlying mechanisms are poorly understood, there is a wealth of data suggesting that this so-called “i
Externí odkaz:
https://doaj.org/article/7ebbef19822844c38fada3f9ca189613
Autor:
Janet E. McElhaney, Chris P. Verschoor, Melissa K. Andrew, Laura Haynes, George A. Kuchel, Graham Pawelec
Publikováno v:
Immunity & Ageing, Vol 17, Iss 1, Pp 1-10 (2020)
Abstract Despite widespread influenza vaccination programs, influenza remains a major cause of morbidity and mortality in older adults. Age-related changes in multiple aspects of the adaptive immune response to influenza have been well-documented inc
Externí odkaz:
https://doaj.org/article/db4a68d7df644345ac26d0107b5998a1
Publikováno v:
BMC Immunology, Vol 21, Iss 1, Pp 1-7 (2020)
Abstract Background Quantitative PCR (qPCR) is a powerful tool that is particularly well-suited to measure mRNA levels in clinical samples, especially those with relatively low cell counts. However, a caveat of this approach is that reliable, stably
Externí odkaz:
https://doaj.org/article/583ab8a137ef45609cacf228a64575a2
Autor:
Lidia Oostvogels, Thomas C. Heineman, Robert W. Johnson, Myron J. Levin, Janet E. McElhaney, Peter Van den Steen, Toufik Zahaf, Alemnew F. Dagnew, Roman Chlibek, Javier Diez-Domingo, Iris S. Gorfinkel, Caroline Hervé, Shinn-Jang Hwang, Hideyuki Ikematsu, George Kalema, Himal Lal, Shelly A. McNeil, Tomas Mrkvan, Karlis Pauksens, Jan Smetana, Daisuke Watanabe, Lily Yin Weckx, Anthony L. Cunningham
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 15, Iss 12, Pp 2865-2872 (2019)
In two pivotal efficacy studies (ZOE-50; ZOE-70), the adjuvanted recombinant zoster vaccine (RZV) demonstrated >90% efficacy against herpes zoster (HZ). Adults aged ≥50 or ≥70 years (ZOE-50 [NCT01165177]; ZOE-70 [NCT01165229]) were randomized to
Externí odkaz:
https://doaj.org/article/2de77cc0739443df82239135c7c026b5
Autor:
Chris P. Verschoor, Graham Pawelec, Laura Haynes, Mark Loeb, Melissa K. Andrew, George A. Kuchel, Janet E. McElhaney
Publikováno v:
Frontiers in Aging, Vol 2 (2021)
Background: Influenza-specific cytolytic T lymphocytes (CTL) have a critical role in clearing the virus from the lungs, but are poorly stimulated by current inactivated influenza vaccines. Our previous work suggests that granzyme B (GrB) activity pre
Externí odkaz:
https://doaj.org/article/75f3f32a0eb14c519be15deda1c48049
Autor:
Arun Kumar, Janet E. McElhaney, Lisa Walrond, Terry D. Cyr, Shahzma Merani, Tobias R. Kollmann, Scott A. Halperin, David W. Scheifele
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 13, Iss 9, Pp 2048-2057 (2017)
Cellular immunity is important for protection against the serious complications of influenza in older adults. As it is unclear if newer influenza vaccines elicit greater cellular responses than standard vaccines, we compared responses to 2 standard a
Externí odkaz:
https://doaj.org/article/8a3fae832d714332a68ad9a78a3a1dc6
Autor:
Chris P. Verschoor, Melissa K. Andrew, Mark Loeb, Graham Pawelec, Laura Haynes, George A. Kuchel, Janet E. McElhaney
Publikováno v:
Vaccines, Vol 9, Iss 1, p 25 (2021)
Despite efforts to design better vaccines for older adults, the risk for serious complications of influenza remains disproportionately high. Identifying correlates of vaccine effectiveness and understanding the heterogeneity of health outcomes in old
Externí odkaz:
https://doaj.org/article/80c887dc2281417ebf899e2b4c205b8d
Impact of Aging and Cytomegalovirus on Immunological Response to Influenza Vaccination and Infection
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The number of people over the age of 60 is expected to double by 2050 according to the WHO. This emphasizes the need to ensure optimized resilience to health stressors in late life. In older adults, influenza is one of the leading causes of catastrop
Externí odkaz:
https://doaj.org/article/7b43ee85e23a4e69b917f6cfcc3ace89
Autor:
Jessica A. Breznik, Ahmad Rahim, Tara Kajaks, Megan Hagerman, Lucas Bilaver, Karen Colwill, Roaya M. Dayam, Anne-Claude Gingras, Chris P. Verschoor, Janet E. McElhaney, Jonathan L. Bramson, Dawn M. E. Bowdish, Andrew P. Costa
Publikováno v:
Journal of the American Medical Directors Association. 24:753-758
ObjectivesTo identify factors that contribute to protection from infection with the Omicron variant of SARS-CoV-2 in older adults in nursing and retirement homes.DesignLongitudinal cohort study with retrospective analysis of infection risk.Setting an