Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Janet E. McCombs"'
Autor:
Chenxiao Wang, Mst Shamima Khatun, Calder R. Ellsworth, Zheng Chen, Mohammad Islamuddin, Ana Karina Nisperuza Vidal, Mohammad Afaque Alam, Shumei Liu, Janet E. Mccombs, Nicholas J. Maness, Robert V. Blair, Jay K. Kolls, Xuebin Qin
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Toll-like receptor 7 (Tlr7) deficiency-accelerated severe COVID-19 is associated with reduced production of interferons (IFNs). However, the underlying mechanisms remain elusive. To address these questions, we utilize Tlr7 and Irf7 deficienc
Externí odkaz:
https://doaj.org/article/5e54acc9b17c45a78d7bba3cb4b56d54
Autor:
Joseph P. Hoffmann, Akhilesh Srivastava, Haoran Yang, Naoki Iwanaga, T. Parks Remcho, Jenny L. Hewes, Rayshma Sharoff, Kejing Song, Elizabeth B. Norton, Jay K. Kolls, Janet E. McCombs
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Lung tissue resident memory (TRM) cells are thought to play crucial roles in lung host defense. We have recently shown that immunization with the adjuvant LTA1 (derived from the A1 domain of E. coli heat labile toxin) admixed with OmpX from
Externí odkaz:
https://doaj.org/article/a125ff03d41c44a3a7c6aacd13ce9e42
Autor:
Kristin Noell, Guixiang Dai, Dora Pungan, Anna Ebacher, Janet E. McCombs, Samuel J. Landry, Jay K. Kolls
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Pneumocystis is the most common fungal pulmonary infection in children under the age of 5 years. In children with primary immunodeficiency, Pneumocystis often presents at 3–6 months of age, a time period that coincides with the nadir of maternal Ig
Externí odkaz:
https://doaj.org/article/dabb1d72bf4a42cca8fd8aeb0b069a44
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Lower respiratory infections are among the leading causes of morbidity and mortality worldwide. These potentially deadly infections are further exacerbated due to the growing incidence of antimicrobial resistance. To combat these infections there is
Externí odkaz:
https://doaj.org/article/28ee6f19cd31498a9119fe0e7377bbd2
Autor:
Kong Chen, Jay K. Kolls, Alanna Wanek, Kejing Song, Naoki Iwanaga, Janet E. McCombs, Haoran Yang, Elizabeth B. Norton, Javier Rangel-Moreno, Joseph P. Hoffmann, Shiping Lu
Publikováno v:
Science Immunology. 6
A subunit mucosal vaccine conferred protection against heterologous Klebsiella pneumoniae strains, via IL-17R signaling in lung fibroblasts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f39420e67b50bc6f286694dc6f1b491a
https://doi.org/10.1126/sciimmunol.abf1198
https://doi.org/10.1126/sciimmunol.abf1198
Autor:
Naoki, Iwanaga, Kong, Chen, Haoran, Yang, Shiping, Lu, Joseph P, Hoffmann, Alanna, Wanek, Janet E, McCombs, Kejing, Song, Javier, Rangel-Moreno, Elizabeth B, Norton, Jay K, Kolls
Publikováno v:
Sci Immunol
Tissue resident memory (TRM) cells are thought to play a role in lung mucosal immunity to pathogens, but strategies to elicit TRM by mucosal vaccines have not yet been fully realized. Here, we formulated a vaccine composed of outer membrane protein (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::81c8ca74478cb7e6c1d068e911528a61
https://pubmed.ncbi.nlm.nih.gov/34516780
https://pubmed.ncbi.nlm.nih.gov/34516780
Autor:
Amberlyn M Wands, Akiko Fujita, Janet E McCombs, Jakob Cervin, Benjamin Dedic, Andrea C Rodriguez, Nicole Nischan, Michelle R Bond, Marcel Mettlen, David C Trudgian, Andrew Lemoff, Marianne Quiding-Järbrink, Bengt Gustavsson, Catharina Steentoft, Henrik Clausen, Hamid Mirzaei, Susann Teneberg, Ulf Yrlid, Jennifer J Kohler
Publikováno v:
eLife, Vol 4 (2015)
Cholera toxin (CT) enters and intoxicates host cells after binding cell surface receptors using its B subunit (CTB). The ganglioside (glycolipid) GM1 is thought to be the sole CT receptor; however, the mechanism by which CTB binding to GM1 mediates i
Externí odkaz:
https://doaj.org/article/3c68ba7482ae44199ba3d13b04350700
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Lower respiratory infections are among the leading causes of morbidity and mortality worldwide. These potentially deadly infections are further exacerbated due to the growing incidence of antimicrobial resistance. To combat these infections there is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7a58c4c798f73f23107c408053ea8f
Publikováno v:
JCI Insight
Infections due to carbapenem-resistant Klebsiella pneumoniae have emerged as a global threat due to its widespread antimicrobial resistance. Transplant recipients and patients with hematologic malignancies have high mortality rate, suggesting host fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1713fa54539f05e3e5cf1dd09bcfa40
https://doi.org/10.1172/jci.insight.135591
https://doi.org/10.1172/jci.insight.135591
Walking down the 'IL': The Newfound Marriage between IL-36 and Chronic Obstructive Pulmonary Disease
Autor:
Jay K. Kolls, Janet E. McCombs
Publikováno v:
Am J Respir Cell Mol Biol
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disease with high morbidity and mortality. The IL-36 family are proinflammatory cytokines that are known to shape innate immune responses, including those critical to bac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21515103090f92ee1ae5cc26e1fd0619
https://doi.org/10.1165/rcmb.2020-0461ed
https://doi.org/10.1165/rcmb.2020-0461ed