Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Janet E. Daigle"'
Publikováno v:
PLoS Pathogens, Vol 5, Iss 3, p e1000327 (2009)
Retroviruses and retrotransposons are vulnerable to a suicidal pathway known as autointegration, which occurs when the 3'-ends of the reverse transcript are activated by integrase and then attack sites within the viral DNA. Retroelements have diverse
Externí odkaz:
https://doaj.org/article/bf1303394b94403c9636b95293a676f7
Autor:
Janet E. Daigle, Webster L. Santos, Jacques J. Kessl, Christopher McKee, Zhuojun Zhao, Mamuka Kvaratskhelia, Gregory L. Verdine, Alan Engelman
Publikováno v:
Journal of Biological Chemistry. 283:5632-5641
To identify functional contacts between HIV-1 integrase (IN) and its viral DNA substrate, we devised a new experimental strategy combining the following two methodologies. First, disulfide-mediated cross-linking was used to site-specifically link sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e879d282c207e068ef19923bb045f834
https://doi.org/10.1074/jbc.m705241200
https://doi.org/10.1074/jbc.m705241200
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 51
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea662c9fc87ddfe2210cc86b7679975e
https://doi.org/10.1097/01.qai.0000351113.80299.b3
https://doi.org/10.1097/01.qai.0000351113.80299.b3
Autor:
Peter Cherepanov, Alan Engelman, Ming-Chieh Shun, Paul Kellam, Janet E. Daigle, Nick Vandegraaff, Nidhanapati K. Raghavendra, Siobhan M. Hughes
LEDGF/p75 directly interacts with lentiviral integrase proteins and can modulate their enzymatic activities and chromosomal association. A novel genetic knockout model was established that allowed us for the first time to analyze HIV-1 integration in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac47c3918df1a021003a80c3f10709f
https://europepmc.org/articles/PMC1920171/
https://europepmc.org/articles/PMC1920171/
Publikováno v:
Journal of virology. 81(1)
Preintegration complexes (PICs) mediate retroviral integration, and recent results indicate an important role for the inner nuclear membrane protein emerin in orienting human immunodeficiency virus type 1 (HIV-1) PICs to chromatin for integration. Tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5456c2f5f167d4d880cf1b33a2953a1c
https://pubmed.ncbi.nlm.nih.gov/17035312
https://pubmed.ncbi.nlm.nih.gov/17035312
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 5, Iss 3, p e1000327 (2009)
PLoS Pathogens, Vol 5, Iss 3, p e1000327 (2009)
Retroviruses and retrotransposons are vulnerable to a suicidal pathway known as autointegration, which occurs when the 3′-ends of the reverse transcript are activated by integrase and then attack sites within the viral DNA. Retroelements have diver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9d960e354cabe992ce007fb16bea9f
https://doi.org/10.1371/journal.ppat.1000327
https://doi.org/10.1371/journal.ppat.1000327