Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Janet E, Deane"'
Autor:
Charlotte Lefèvre, Georgia M. Cook, Adam M. Dinan, Shiho Torii, Hazel Stewart, George Gibbons, Alex S. Nicholson, Liliana Echavarría-Consuegra, Luke W. Meredith, Valeria Lulla, Naomi McGovern, Julia C. Kenyon, Ian Goodfellow, Janet E. Deane, Stephen C. Graham, András Lakatos, Louis Lambrechts, Ian Brierley, Nerea Irigoyen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Zika virus (ZIKV), an emerging mosquito-borne flavivirus, is associated with congenital neurological complications. Here, we investigate potential pathological correlates of virus gene expression in representative ZIKV strains through RNA se
Externí odkaz:
https://doaj.org/article/2dc4a2034fc449a8bca35da7cbd3b0c0
Autor:
Prasun Kundu, Deboki Naskar, Shannon J. McKie, Sheena Dass, Usheer Kanjee, Viola Introini, Marcelo U. Ferreira, Pietro Cicuta, Manoj Duraisingh, Janet E. Deane, Julian C. Rayner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Tryptophan Rich Antigens (TRAgs) are encoded by a multi-gene family found in all Plasmodium species, but are significantly expanded in P. vivax and closely related parasites. We show that multiple P. vivax TRAgs are expressed on the merozoit
Externí odkaz:
https://doaj.org/article/1d5db4ca321d48589e92ba6963931162
Autor:
Hashim Ali, Aleksei Lulla, Alex S Nicholson, Jacqueline Hankinson, Elizabeth B Wignall-Fleming, Rhian L O'Connor, Diem-Lan Vu, Stephen C Graham, Janet E Deane, Susana Guix, Valeria Lulla
Publikováno v:
PLoS Biology, Vol 21, Iss 7, p e3001815 (2023)
During the last decade, the detection of neurotropic astroviruses has increased dramatically. The MLB genogroup of astroviruses represents a genetically distinct group of zoonotic astroviruses associated with gastroenteritis and severe neurological c
Externí odkaz:
https://doaj.org/article/e8a8b4e39a874fd7b4e555bd3fe2873d
Autor:
Iain M Hay, Katie E Mulholland, Tiffany Lai, Stephen C Graham, Hayley J Sharpe, Janet E Deane
Publikováno v:
eLife, Vol 11 (2022)
Protein tyrosine phosphatase receptor-type kappa (PTPRK) is a transmembrane receptor that links extracellular homophilic interactions to intracellular catalytic activity. Previously we showed that PTPRK promotes cell–cell adhesion by selectively de
Externí odkaz:
https://doaj.org/article/568308e577d14b4daa1cbcb5503554d2
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Receptor-linked protein tyrosine phosphatases (RPTPs) usually contain an active membrane proximal domain and an inactive pseudophosphatase domain. Here, the authors characterize an RPTP with two pseudophosphatase domains, providing evidence that it m
Externí odkaz:
https://doaj.org/article/43b379ce65a14ab3b79e3d114119ae48
Autor:
Tomasz H Benedyk, Julia Muenzner, Viv Connor, Yue Han, Katherine Brown, Kaveesha J Wijesinghe, Yunhui Zhuang, Susanna Colaco, Guido A Stoll, Owen S Tutt, Stanislava Svobodova, Dmitri I Svergun, Neil A Bryant, Janet E Deane, Andrew E Firth, Cy M Jeffries, Colin M Crump, Stephen C Graham
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010225 (2022)
[This corrects the article DOI: 10.1371/journal.ppat.1009824.].
Externí odkaz:
https://doaj.org/article/8c201b0792ce4d5f96823b0806ce40e6
Publikováno v:
Contact, Vol 4 (2021)
Saposins are lipid transfer proteins required for the degradation of sphingolipids in the lysosome. These small proteins bind lipids by transitioning from a closed, monomeric state to an open conformation exposing a hydrophobic surface that binds and
Externí odkaz:
https://doaj.org/article/f16a0239b43e4d07a7ee17ab3e4f21b6
Autor:
Tomasz H Benedyk, Julia Muenzner, Viv Connor, Yue Han, Katherine Brown, Kaveesha J Wijesinghe, Yunhui Zhuang, Susanna Colaco, Guido A Stoll, Owen S Tutt, Stanislava Svobodova, Dmitri I Svergun, Neil A Bryant, Janet E Deane, Andrew E Firth, Cy M Jeffries, Colin M Crump, Stephen C Graham
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009824 (2021)
The herpes simplex virus (HSV)-1 protein pUL21 is essential for efficient virus replication and dissemination. While pUL21 has been shown to promote multiple steps of virus assembly and spread, the molecular basis of its function remained unclear. He
Externí odkaz:
https://doaj.org/article/9b5aa75bb49e4f8c89bf26a7c76fbb8a
Autor:
Sara Marelli, James C Williamson, Anna V Protasio, Adi Naamati, Edward JD Greenwood, Janet E Deane, Paul J Lehner, Nicholas J Matheson
Publikováno v:
eLife, Vol 9 (2020)
The seminal description of the cellular restriction factor APOBEC3G and its antagonism by HIV-1 Vif has underpinned two decades of research on the host-virus interaction. We recently reported that HIV-1 Vif is also able to degrade the PPP2R5 family o
Externí odkaz:
https://doaj.org/article/207cba6cd24e44cfbd68b5a7f96b6775
Autor:
Chris H. Hill, Georgia M. Cook, Samantha J. Spratley, Stuart Fawke, Stephen C. Graham, Janet E. Deane
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Lysosomal degradation of sphingolipids requires lipid-binding saposin proteins and hydrolytic enzymes. Here the authors present the crystal structure of the hydrolase β-galactocerebrosidase in complex with saposin SapA and give insights into the gly
Externí odkaz:
https://doaj.org/article/2892fdb00d5d43eb9babf8bf3fb7a3dc